Evidence map›Paper›PMID 30643454›Full record

ArticleCancer management and research2019

Polymorphisms in DNA repair pathway genes and

Xiaoyun Hu, Wenyan Qin, Shanqiong Li, Miao He, Yilin Wang, Shu Guan, Haishan Zhao, Weifan Yao, Minjie Wei, Mingyan Liu and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancer management and research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. miRNA-Based Technologies in Cancer Therapy.Journal of personalized medicine · 2023
    Review
  6. Article
  7. Article
  8. Pharmaceutics · 2021
    Article
  9. Article
  10. XPA: DNA Repair Protein of Significant Clinical Importance.International journal of molecular sciences · 2020
    Review
  11. Article
  12. Article
  13. Variation in thePharmacogenomics
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Xiaoyun HuDepartment of Pharmacology, School of Pharmacy, Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation, China Medical University, Shenyang 110122, China, wuhz@cmu.edu.cn; saffer@163.com.
Wenyan QinDepartment of Pharmacology, School of Pharmacy, Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation, China Medical University, Shenyang 110122, China, wuhz@cmu.edu.cn; saffer@163.com.
Shanqiong LiDepartment of Pharmacology, School of Pharmacy, Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation, China Medical University, Shenyang 110122, China, wuhz@cmu.edu.cn; saffer@163.com.
Miao HeDepartment of Pharmacology, School of Pharmacy, Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation, China Medical University, Shenyang 110122, China, wuhz@cmu.edu.cn; saffer@163.com.
Yilin WangDepartment of Pharmacology, School of Pharmacy, Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation, China Medical University, Shenyang 110122, China, wuhz@cmu.edu.cn; saffer@163.com.
Shu GuanDepartment of Breast Surgery, First Hospital of China Medical University, Shenyang 110001, China.
Haishan ZhaoDepartment of Pharmacology, School of Pharmacy, Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation, China Medical University, Shenyang 110122, China, wuhz@cmu.edu.cn; saffer@163.com.
Weifan YaoDepartment of Pharmacology, School of Pharmacy, Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation, China Medical University, Shenyang 110122, China, wuhz@cmu.edu.cn; saffer@163.com.
Minjie WeiDepartment of Pharmacology, School of Pharmacy, Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation, China Medical University, Shenyang 110122, China, wuhz@cmu.edu.cn; saffer@163.com.
Mingyan LiuDepartment of Pharmacology, School of Pharmacy, Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation, China Medical University, Shenyang 110122, China, wuhz@cmu.edu.cn; saffer@163.com.
Huizhe WuDepartment of Pharmacology, School of Pharmacy, Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation, China Medical University, Shenyang 110122, China, wuhz@cmu.edu.cn; saffer@163.com.
China Medical University · CNFirst Hospital of China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMultiple factors are involved in oxaliplatin-resistant process in colorectal cancer (CRC) patients including decreased drug accumulation and enhanced capacity to repair and tolerate DNA damage. In the present study, we aimed to assess the impact of six single-nucleotide polymorphisms (SNPs) in DNA repair genes and

methodsIn this study, 580 advanced CRC patients were recruited. Six SNPs of DNA repair genes (

resultsRegarding interaction with environmental factors,

conclusionThe current data indicated that the

Indexed as

ABCG2colorectal cancerDNA repair pathwaygenetic variationoxaliplatinprognosis

Identifiers

PMID30643454
PMCPMC6312053
OpenAlexW2905708503

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.