Evidence map›Paper›PMID 30643435›Full record

ArticleInfection and drug resistance2019

Silencing of

Nancy E Lozoya-Pérez, Sergio Casas-Flores, José Roberto Fogaça de Almeida, José A Martínez-Álvarez, Luz A López-Ramírez, Grasielle Pereira Jannuzzi, Elías Trujillo-Esquivel, Eine Estrada-Mata, Sandro R Almeida, Bernardo Franco and 2 more

Open access · goldAbstract read
In one paragraph

Article in Infection and drug resistance, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 24 citations in OpenAlex.

  1. Genetic Manipulation inJournal of fungi (Basel, Switzerland) · 2026
    Review
  2. Article
  3. Current Insights intoJournal of fungi (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Cell surface (Amsterdam, Netherlands) · 2025
    Article
  6. Silencing ofJournal of fungi (Basel, Switzerland) · 2025
    Article
  7. Article
  8. Differential Recognition of Clinically RelevantJournal of fungi (Basel, Switzerland) · 2023
    Article
  9. Differential Recognition of Clinically RelevantJournal of fungi (Basel, Switzerland) · 2023
    Article
  10. Review
  11. Differential Recognition ofInfection and drug resistance · 2023
    Article
  12. Silencing ofJournal of fungi (Basel, Switzerland) · 2022
    Article
  13. The Search for Cryptic L-Rhamnosyltransferases on theJournal of fungi (Basel, Switzerland) · 2022
    Article
  14. Current Models to Study theFrontiers in fungal biology · 2022
    Review
  15. Article
  16. Disruption of protein rhamnosylation affects theCell surface (Amsterdam, Netherlands) · 2021
    Article
  17. The Heat Shock Protein 60 and Pap1 Participate in theJournal of fungi (Basel, Switzerland) · 2021
    Article
  18. Review
  19. Infection and drug resistance · 2021
    Article
  20. Influences of the Culturing Media in the Virulence and Cell Wall ofJournal of fungi (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Nancy E Lozoya-PérezDepartment of Biology, Division of Exact and Natural Sciences, Universidad de Guanajuato, Guanajuato, Mexico, hmora@ugto.mx.
Sergio Casas-FloresDivision of Molecular Biology, IPICYT, San Luis Potosí, Mexico.
José Roberto Fogaça de AlmeidaLaboratory of Clinical Mycology, Faculty of Pharmacy, Universidade de São Paulo, São Paulo, Brazil.
José A Martínez-ÁlvarezDepartment of Biology, Division of Exact and Natural Sciences, Universidad de Guanajuato, Guanajuato, Mexico, hmora@ugto.mx.
Luz A López-RamírezDepartment of Biology, Division of Exact and Natural Sciences, Universidad de Guanajuato, Guanajuato, Mexico, hmora@ugto.mx.
Grasielle Pereira JannuzziLaboratory of Clinical Mycology, Faculty of Pharmacy, Universidade de São Paulo, São Paulo, Brazil.
Elías Trujillo-EsquivelDepartment of Biology, Division of Exact and Natural Sciences, Universidad de Guanajuato, Guanajuato, Mexico, hmora@ugto.mx.
Eine Estrada-MataDepartment of Biology, Division of Exact and Natural Sciences, Universidad de Guanajuato, Guanajuato, Mexico, hmora@ugto.mx.
Sandro R AlmeidaLaboratory of Clinical Mycology, Faculty of Pharmacy, Universidade de São Paulo, São Paulo, Brazil.
Bernardo FrancoDepartment of Biology, Division of Exact and Natural Sciences, Universidad de Guanajuato, Guanajuato, Mexico, hmora@ugto.mx.
Leila M Lopes-BezerraLaboratory of Clinical Mycology, Faculty of Pharmacy, Universidade de São Paulo, São Paulo, Brazil.
Héctor M Mora-MontesDepartment of Biology, Division of Exact and Natural Sciences, Universidad de Guanajuato, Guanajuato, Mexico, hmora@ugto.mx.
Universidad de Guanajuato · MXUniversidade de São Paulo · BRInstitute for Scientific and Technological Research · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

methodsHere, we silenced

resultsThe mutant strains did not show defects in the cell or colony morphology, the growth rate or the ability to undergo dimorphism; but the cell wall changed in both composition and exposure of inner components at the surface. When interacting with human monocytes, the silenced strains had a reduced ability to stimulate TNFα and IL-6 but stimulated higher levels of IL-10. The interaction with human macrophages was also altered, with reduced numbers of silenced cells phagocytosed. These strains showed virulence attenuation in both

conclusionOur data demonstrate that

Indexed as

cell wallgene silencinghost–fungus interplaymannosyltransferaseprotein glycosylationsporotrichosis

Identifiers

PMID30643435
PMCPMC6312695
OpenAlexW2907618340

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.