Evidence map›Paper›PMID 30643362›Full record

ArticleWorld journal of gastroenterology2019

Usefulness of urinary trypsinogen-2 and trypsinogen activation peptide in acute pancreatitis: A multicenter study in Japan.

Hiroaki Yasuda, Keisho Kataoka, Yoshifumi Takeyama, Kazunori Takeda, Tetsuhide Ito, Toshihiko Mayumi, Shuji Isaji, Tetsuya Mine, Motoji Kitagawa, Seiki Kiriyama and 18 more

Open access · hybridAbstract readEvaluation StudyMulticenter StudyValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Acute pancreatitis: mechanisms and therapeutic approaches.Signal transduction and targeted therapy · 2026
    Review
  3. Article
  4. Review
  5. Utility of a noninvasive urine-based test for diagnosing acute pancreatitis in children.Journal of pediatric gastroenterology and nutrition · 2025
    Article
  6. Article
  7. Lysine acetylation and its role in the pathophysiology of acute pancreatitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Diagnosis and Treatment of Acute Pancreatitis.Diagnostics (Basel, Switzerland) · 2022
    Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 14 institutions in 1 country.

Hiroaki YasudaDepartment of Medicine, Division of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto 6028566, Japan. hiyasuda@koto.kpu-m.ac.jp.
Keisho KataokaDepartment of Medicine, Division of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto 6028566, Japan.
Yoshifumi TakeyamaDepartment of Surgery, Kindai University Faculty of Medicine, Osakasayama 5898511, Japan.
Kazunori TakedaDepartment of Surgery, National Hospital Organization Sendai Medical Center, Sendai 9838520, Japan.
Tetsuhide ItoDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 8128582, Japan.
Toshihiko MayumiDepartment of Emergency Medicine, University of Occupational and Environmental Health, Kitakyushu 8078555, Japan.
Shuji IsajiDepartment of Hepatobiliary-Pancreatic and Transplant Surgery, Mie University School of Medicine, Tsu 5148507, Japan.
Tetsuya MineDepartment of Gastroenterology, Tokai University School of Medicine, Isehara 2591193, Japan.
Motoji KitagawaDepartment of Nutritional Sciences, Nagoya University of Arts and Sciences, Nisshin 4700196, Japan.
Seiki KiriyamaDepartment of Gastroenterology, Ogaki Municipal Hospital, Ogaki 5038502, Japan.
Junichi SakagamiDepartment of Medicine, Division of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto 6028566, Japan.
Atsushi MasamuneDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
Kazuo InuiDepartment of Gastroenterology, Fujita Health University Bantane Hospital, Nagoya 4548509, Japan.
Kenji HiranoDepartment of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo 1130033, Japan.
Ryukichi AkashiDepartment of Healthcare Center, Kumamoto Regional Medical Center, Kumamoto 8600811, Japan.
Masamichi YokoeGeneral Internal Medicine, Japanese Red Cross Nagoya Daini Hospital, Nagoya 4668650, Japan.
Yoshio SogameDepartment of Medicine, Division of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto 6028566, Japan.
Kazuichi OkazakiThe Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Hirakata 5731010, Japan.
Chie MoriokaThird Department of Internal Medicine, Nara Medical University, Kashihara 6348521, Japan.
Yasuyuki KiharaDepartment of Gastroenterology, Kitakyushu General Hospital, Kitakyushu 8028517, Japan.
Shigeyuki KawaDepartment of Internal Medicine, Matsumoto Dental University, Shiojiri 3990781, Japan.
Masao TanakaDepartment of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 8128582, Japan.
Akira AndohDivision of Gastroenterology, Department of Internal Medicine, Shiga University of Medical Science, Otsu 5202192, Japan.
Wataru KimuraDepartment of Gastroenterological, General, Breast and Thyroid Surgery, Yamagata University Faculty of Medicine, Yamagata 9909585, Japan.
Isao NishimoriDepartment of Gastroenterology and Hepatology, Kochi Medical School, Nankoku 7838505, Japan.
Junji FuruseFaculty of Medicine, Department of Medical Oncology, Kyorin University, Mitaka 1818611, Japan.
Isao YokotaDepartment of Biostatistics, Hokkaido University, Sapporo 0600808 Japan.
Tooru ShimosegawaDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 9808575, Japan.
Kyushu University · JPTohoku University · JPFujita Health University Bantane HospitalKindai University · JPKochi Medical School Hospital · JPKumamoto Medical Center · JPKyorin University · JPMatsumoto Dental University · JPNagoya University of Arts and Sciences · JPSendai Medical Center · JPShiga University of Medical Science · JPThe University of Tokyo · JPUniversity of Occupational and Environmental Health Japan · JPYamagata University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRapid urinary trypsinogen-2 dipstick test and levels of urinary trypsinogen-2 and trypsinogen activation peptide (TAP) concentration have been reported as prognostic markers for the diagnosis of acute pancreatitis.

aimTo reconfirm the validity of all these markers in the diagnosis of acute pancreatitis by undertaking a multi-center study in Japan.

methodsPatients with acute abdominal pain were recruited from 17 medical institutions in Japan from April 2009 to December 2012. Urinary and serum samples were collected twice, at enrollment and on the following day for measuring target markers. The diagnosis and severity assessment of acute pancreatitis were assessed based on prognostic factors and computed tomography (CT) Grade of the Japanese Ministry of Health, Labour, and Welfare criteria.

resultsA total of 94 patients were enrolled during the study period. The trypsinogen-2 dipstick test was positive in 57 of 78 patients with acute pancreatitis (sensitivity, 73.1%) and in 6 of 16 patients with abdominal pain but without any evidence of acute pancreatitis (specificity, 62.5%). The area under the curve (AUC) score of urinary trypsinogen-2 according to prognostic factors was 0.704, which was highest in all parameter. The AUC scores of urinary trypsinogen-2 and TAP according to CT Grade were 0.701 and 0.692, respectively, which shows higher than other pancreatic enzymes. The levels of urinary trypsinogen-2 and TAP were significantly higher in patients with extended extra-pancreatic inflammation as evaluated by CT Grade.

conclusionWe reconfirmed urinary trypsinogen-2 dipstick test is useful as a marker for the diagnosis of acute pancreatitis. Urinary trypsinogen-2 and TAP may be considered as useful markers to determine extra-pancreatic inflammation in acute pancreatitis.

Indexed as

AdultAgedAged, 80 and overArea Under CurveBiomarkersFemaleHumansJapanMaleMiddle AgedOligopeptidesPancreatitisPrognosisProspective StudiesRetrospective StudiesSeverity of Illness IndexBiomarkersOligopeptidesPRSS2 protein, humanTrypsinTrypsinogentrypsinogen activation peptideAcute pancreatitisTrypsinogen activation peptideUrinary trypsinogen-2 dipstick test

Identifiers

PMID30643362
PMCPMC6328966
OpenAlexW2910009518

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.