Answering the Call: A Prospective Look at the Role of Timolol Eye Drops in the Treatment of Acute Migraine Attacks.

Sean Gratton, Matthew Cossack

Abstract readRandomized Controlled Trial

In one paragraph

Trial report in Missouri medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

It Should Not Be This Difficult to Engage Pharma in an Effective, Safe, Inexpensive Product for Acute Migraine, the Third Most Prevalent Disease in the World.Missouri medicine
Article
Nasally Delivered 0.5% Timolol Beta Blocker Successfully Treats Acute Migraines in a Referral Headache Clinic: A Case Series.Missouri medicine
Article
Mixing It Up: The Art and Science of Compounding Pharmacy.Missouri medicine
Article

4 · The record

Corrections and comments

Commented on by
Topical Beta Blockers for the Treatment of Acute Migraines in 2019.

5 · Who and what money

Authors and funding

2 authors.

Sean GrattonSean M Gratton, MD, MSMA member since 2001, is Assistant Professor of Neurology and Ophthalmology, at the University of Missouri - Kansas City.

Matthew CossackMatthew Cossack, MD, was a Senior Resident in Ophthalmology at UMKC School of Medicine when the study was done. He is now in private practice at Essentia Health, Duluth, Minnesota.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Acute DiseaseAdministration, OphthalmicAdrenergic beta-AntagonistsCross-Over StudiesHumansMigraine DisordersOphthalmic SolutionsProspective StudiesSingle-Blind MethodTimololTreatment OutcomeAdrenergic beta-AntagonistsOphthalmic SolutionsTimolol

Identifiers

PMID30643343

PMCPMC6312165

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.