ArticleNature medicine2019
Healthy infants harbor intestinal bacteria that protect against food allergy.
Registry-linked trialAbstract read
In one paragraph
Article in Nature medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05138757 (Fiber Supplementation In Children With Peanut Allergy On Oral Immunotherapy), which is not on this map. Cited by 249 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
249citing papers in PubMed, 1 pooled it
21.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT05138757 phase1 / phase2completednot on this mapstarted 2021, after this paper: background citation
Fiber Supplementation In Children With Peanut Allergy On Oral Immunotherapy: A Randomized Controlled Pilot Study
Who cites it
249 citing papers in PubMed, 1 synthesis or guideline pooled it, 473 citations in OpenAlex.
- Probiotics supplementation during pregnancy or infancy on multiple food allergies and gut microbiota: a systematic review and meta-analysis.Nutrition reviews · 2025Pooled it
- Effect of Lacticaseibacillus casei LC2W Supplementation on Glucose Metabolism and Gut Microbiota in Subjects at High Risk of Metabolic Syndrome: A Randomized, Double-blinded, Placebo-controlled Clinical Trial.Probiotics and antimicrobial proteins · 2025Trial
- Gut microbial bile and amino acid metabolism associate with peanut oral immunotherapy failure.Nature communications · 2025Trial
- Plant-DerivedNutrients · 2022Trial
- Specific gut microbiome signatures and the associated pro-inflamatory functions are linked to pediatric allergy and acquisition of immune tolerance.Nature communications · 2021Trial
- A synbiotic intervention modulates meta-omics signatures of gut redox potential and acidity in elective caesarean born infants.BMC microbiology · 2021Trial
- Childhood allergy is preceded by an absence of gut lactobacilli species and higher levels of atopy-related plasma chemokines.Clinical and experimental immunology · 2020Trial
- Miniature bioreactor arrays for modeling functional and structural dysbiosis in inflammatory bowel disease.Gut microbes · 2026Article
- Diet-Microbiome-Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications.Allergy · 2026Review
- Immunotherapy restores therapeutic efficacy of fecal microbiome transplants to treatbioRxiv : the preprint server for biology · 2026Article
- Article
- The Role ofInternational journal of molecular sciences · 2026Review
- Fecal microbiome transplant in food allergy in humans and mice identifies a role for bile acid metabolites in oral tolerance.Science translational medicine · 2026Article
- Review
- Gut microbial composition modulates endogenous food-specific CD4+ T cells in food allergy.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Lactiplantibacillus plantarum SLpl116 attenuates OVA-induced food allergy with ecological restoration of the gut microbiota and immune rebalancing.NPJ science of food · 2026Article
- Acarbose redirects gut microbiome utilization of dietary carbohydrates to suppress anaphylaxis in mice.Nature microbiology · 2026Article
- Myricetin suppresses whey protein allergenicity: In vitro and in vivo study.Food chemistry. Molecular sciences · 2026Article
- A Case for Anti-IgE Vaccination.Allergy · 2026Review
- Restoring Microbial Balance: Clinical Applications, Challenges, and Future Directions of Fecal Microbiota Transplantation in Pediatric Disorders.Microorganisms · 2026Review
189 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
14 authors at 4 institutions in 2 countries.
Taylor FeehleyDepartment of Pathology and Committee on Immunology, The University of Chicago, Chicago, IL, USA.
Catherine H PlunkettDepartment of Pathology and Committee on Immunology, The University of Chicago, Chicago, IL, USA.
Riyue BaoCenter for Research Informatics, The University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-6105-1704
Sung Min Choi HongDepartment of Pathology and Committee on Immunology, The University of Chicago, Chicago, IL, USA.
Elliot CulleenDepartment of Pathology and Committee on Immunology, The University of Chicago, Chicago, IL, USA.
Pedro Belda-FerreDepartment of Pathology and Committee on Immunology, The University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-6532-1161
Evelyn CampbellDepartment of Pathology and Committee on Immunology, The University of Chicago, Chicago, IL, USA.
Rosita AitoroDepartment of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, Naples, Italy.
Rita NocerinoDepartment of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, Naples, Italy.
Lorella PaparoDepartment of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, Naples, Italy.
Jorge AndradeCenter for Research Informatics, The University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-3210-2186
Dionysios A AntonopoulosDepartment of Medicine, The University of Chicago, Chicago, IL, USA.
Roberto Berni CananiDepartment of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, Naples, Italy.
Cathryn R NaglerDepartment of Pathology and Committee on Immunology, The University of Chicago, Chicago, IL, USA. cnagler@bsd.uchicago.edu.ORCID http://orcid.org/0000-0001-7254-6617
University of Chicago · USUniversity of Naples Federico II · ITArgonne National Laboratory · USCeinge Biotecnologie Avanzate (Italy) · IT
Funding
VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI MARK W. LINGEN · 1985 to 2026
$122.1MThe Institute for Translational MedicineUL1TR002389 · NCATS · UNIVERSITY OF CHICAGO · PI Joshua J Jacobs, DAVID O MELTZER · 2017 to 2026
$71.6MULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI LIU, CAMBRIAN YANGSHAO · 1990 to 2025
$29.8MRe-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2MINTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007090 · NIAID · UNIVERSITY OF CHICAGO · PI Peter Aidan Savage · 1985 to 2026
$11.7MUniversity of Chicago Initiative for Maximizing Student Development (IMSD) - Renewal 01R25GM109439 · NIGMS · UNIVERSITY OF CHICAGO · PI SCHWARTZ, NANCY B · 2014 to 2023
$5.7MProtective role of intestinal microbiota in food allergyR01AI106302 · NIAID · UNIVERSITY OF CHICAGO · PI NAGLER, CATHRYN R · 2014 to 2018
$2.2MMechanisms by which commensal dysbiosis drives allergic responses to foodR56AI134923 · NIAID · UNIVERSITY OF CHICAGO · PI NAGLER, CATHRYN R · 2018 to 2018
$405kNCATS NIH HHS UL1 TR000430NCATS NIH HHS UL1 TR002389NCI NIH HHS P30 CA014599NIAID NIH HHS R01 AI106302NIAID NIH HHS R56 AI134923NIAID NIH HHS T32 AI007090NIDDK NIH HHS P30 DK042086NIGMS NIH HHS R25 GM109439
Abstract
There has been a striking generational increase in life-threatening food allergies in Westernized societies
Indexed as
Fecal Microbiota TransplantationAnaphylaxisAnimalsEubacterialesFemaleFood HypersensitivityGastrointestinal MicrobiomeGerm-Free LifeHealthy VolunteersHumansIleumInfantMaleMiceMilk Hypersensitivity
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT05138757ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.