ArticleNature medicine2019
Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction.
Registry-linked trialAbstract read
In one paragraph
Article in Nature medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06588946 (The Effect of Exogenous Β-OHB Supplementation on Cerebral Blood Flow and Functional Brain Characteristics in Adults with Subjective Cognitive Decline), which is not on this map. Cited by 1,069 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
1,069citing papers in PubMed, 5 pooled it
103.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT06588946 phase2not yet recruitingnot on this mapstarted 2025, after this paper: background citation
The Effect of Exogenous Β-OHB Supplementation on Cerebral Blood Flow and Functional Brain Characteristics in Adults with Subjective Cognitive Decline
Who cites it
1,069 citing papers in PubMed, 5 syntheses or guidelines pooled it, 1,647 citations in OpenAlex.
- Convergent blood-brain barrier breakdown in schizophrenia and autism spectrum disorders: a systematic review of preclinical animal models.Fluids and barriers of the CNS · 2026Pooled it
- Biomarkers for Alzheimer's disease across diverse biological domains: an umbrella review and evidence map.Journal of advanced research · 2026Pooled it
- The role and mechanisms of AMPK in neurovascular unit injury in Parkinson's disease.Frontiers in aging neuroscience · 2026Pooled it
- Differential detectability of pericyte and blood-brain barrier readouts across the Alzheimer's disease clinical continuum: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2026Pooled it
- Identification of cognitive impairment in patients with hypertension: a systematic review and critical appraisal of existing models.Frontiers in medicine · 2026Pooled it
- Mechanisms of electroacupuncture for the treatment of Alzheimer's disease by activating Wnt/β-catenin pathway to improve blood-brain barrier function.IBRO neuroscience reports · 2026Article
- Dysregulated TIE-2 expression is associated with blood-brain barrier leakiness and Alzheimer's disease-related neuropathology.Brain pathology (Zurich, Switzerland) · 2026Article
- Pericyte loss and endothelial activation define distinct vascular states in cerebral small vessel disease.Acta neuropathologica · 2026Article
- Timing and duration of diabetes and incident dementia in older adults: a prospective cohort study.Alzheimer's research & therapy · 2026Article
- The glymphatic-lymphatic axis: known pathways, open questions, and emerging roles in neurodegeneration.Translational neurodegeneration · 2026Review
- Chronic hypertension and social isolation disrupt the blood-brain barrier and memory in a sex-dependent manner.Neurobiology of disease · 2026Article
- Advancing PROTAC therapeutics through chemistry-guided design of smart delivery systems.Acta pharmacologica Sinica · 2026Review
- Animal models of multi-infarct dementia: Methodological approaches, neuropathology, functional outcomes, and translational relevance.Experimental neurology · 2026Review
- Article
- Pharmacological modulation of cGAS-STING-NLRP3 signaling by nano-immunomodulators in Alzheimer and Parkinson disease.Inflammopharmacology · 2026Review
- The Roles of Transcription Factor Ets-1 in Neurological Disorders.Molecular neurobiology · 2026Review
- Article
- Border-Associated Macrophage Migrasomes in Alzheimer's Disease: An Emerging Aβ-Senescence-Microglia Axis?Cells · 2026Review
- Huntington's disease vasculopathy is barrier-type-selective and arteriolar-dominant with spatially-coupled astrogliosis and reversible by S1pr1 stimulation.Nature communications · 2026Article
- Regulation of PDGF-BB signaling in placental pericytes by soluble PDGFRβ isoforms: implications for fetoplacental vascular development.Angiogenesis · 2026Article
1,009 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors at 3 institutions in 1 country.
Daniel A NationDepartment of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Melanie D SweeneyDepartment of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-9009-6488
Axel MontagneDepartment of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Abhay P SagareDepartment of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Lina M D'OrazioAlzheimer's Disease Research Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Maricarmen PachicanoDepartment of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Farshid SepehrbandLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-4483-5961
Amy R NelsonDepartment of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
David P BuennagelHuntington Medical Research Institutes, Pasadena, CA, USA.
Michael G HarringtonHuntington Medical Research Institutes, Pasadena, CA, USA.
Tammie L S BenzingerDepartment of Radiology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-8114-0552
Anne M FaganThe Hope Center for Neurodegenerative Disorders, Washington University School of Medicine, St. Louis, MO, USA.
John M RingmanAlzheimer's Disease Research Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Lon S SchneiderAlzheimer's Disease Research Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
John C MorrisThe Hope Center for Neurodegenerative Disorders, Washington University School of Medicine, St. Louis, MO, USA.
Helena C ChuiAlzheimer's Disease Research Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Meng LawAlzheimer's Disease Research Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Arthur W TogaAlzheimer's Disease Research Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Berislav V ZlokovicDepartment of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. zlokovic@usc.edu.ORCID http://orcid.org/0000-0002-6802-8232
University of Southern California · USWashington University in St. Louis · USHuntington Medical Research Institutes · US
Funding
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger · 1985 to 2026
$69.5MWASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1MThe natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI SCHINDLER, SUZANNE ELIZABETH · 2005 to 2025
$49.5MVASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARANDA, MARIA P. · 1985 to 2019
$41.0MVascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's DiseaseP01AG052350 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation, ARTHUR W TOGA · 2016 to 2026
$28.4MAlzheimer's Abeta, Tau, Apolipoproteins and Blood-brain barrierR01NS034467 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YASSINE, HUSSEIN N · 1995 to 2024
$9.1MThe delivery of essential fatty acids to the Brain in Alzheimer's diseaseR01AG054434 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YASSINE, HUSSEIN N · 2017 to 2021
$5.4MBiomarkers of ABCA1 mediated functions in Alzheimers diseaseR01AG055770 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YASSINE, HUSSEIN N · 2017 to 2021
$4.2MThe role of pericytes in the aging brain and pathogenesis and treatment of neurodegeneration, and Alzheimer's A-beta and tau pathologyRF1AG039452 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ICHIDA, JUSTIN KAWIKA · 2019 to 2019
$4.0MThe role of pericytes in white matter diseaseR01NS100459 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZLOKOVIC, BERISLAV V · 2016 to 2020
$3.6MActivated protein C system in stroke modelsR01NS090904 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZLOKOVIC, BERISLAV V · 2014 to 2018
$3.2MCerebrovascular beta-Amyloidosis: A-beta CNS Transport PathwaysR01AG023084 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZLOKOVIC, BERISLAV V · 2015 to 2019
$3.0MNIA NIH HHS K99 AG058780NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P01 AG052350NIA NIH HHS P50 AG005142NIA NIH HHS P50 AG005681NIA NIH HHS R00 AG058780NIA NIH HHS R01 AG023084NIA NIH HHS R01 AG039452NIA NIH HHS R01 AG054434NIA NIH HHS R01 AG055770NIA NIH HHS R21 AG055034NIA NIH HHS RF1 AG039452NINDS NIH HHS R01 NS034467NINDS NIH HHS R01 NS090904NINDS NIH HHS R01 NS100459
Abstract
Vascular contributions to cognitive impairment are increasingly recognized
Indexed as
Amyloid beta-PeptidesBiomarkersBlood-Brain BarrierCognitive DysfunctionHumansImaging, Three-DimensionalReceptor, Platelet-Derived Growth Factor betatau ProteinsAmyloid beta-PeptidesBiomarkersReceptor, Platelet-Derived Growth Factor betatau Proteins
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
NCT06588946ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.