Evidence map›Paper›PMID 30643285›Full record

ArticleNature medicine2019

Biomimetic 3D-printed scaffolds for spinal cord injury repair.

Jacob Koffler, Wei Zhu, Xin Qu, Oleksandr Platoshyn, Jennifer N Dulin, John Brock, Lori Graham, Paul Lu, Jeff Sakamoto, Martin Marsala and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 291 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
291citing papers in PubMed, 3 pooled it
38.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

291 citing papers in PubMed, 3 syntheses or guidelines pooled it, 684 citations in OpenAlex.

  1. Pooled it
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  4. Review
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  9. Beyond Scar Removal: Reprogramming the Glial Scar for Neural Repair.International journal of molecular sciences · 2026
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231 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Jacob KofflerDepartment of Neuroscience, University of California San Diego, La Jolla, CA, USA. ykoffler@ucsd.edu.ORCID http://orcid.org/0000-0002-8415-2938
Wei ZhuDepartment of NanoEngineering, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-2524-0866
Xin QuDepartment of NanoEngineering, University of California San Diego, La Jolla, CA, USA.
Oleksandr PlatoshynDepartment of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
Jennifer N DulinDepartment of Neuroscience, University of California San Diego, La Jolla, CA, USA.
John BrockDepartment of Neuroscience, University of California San Diego, La Jolla, CA, USA.
Lori GrahamDepartment of Neuroscience, University of California San Diego, La Jolla, CA, USA.
Paul LuDepartment of Neuroscience, University of California San Diego, La Jolla, CA, USA.
Jeff SakamotoMechanical Engineering Department, University of Michigan, Ann Arbor, MI, USA.
Martin MarsalaDepartment of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
Shaochen ChenDepartment of NanoEngineering, University of California San Diego, La Jolla, CA, USA. chen168@eng.ucsd.edu.ORCID http://orcid.org/0000-0001-6876-497X
Mark H TuszynskiDepartment of Neuroscience, University of California San Diego, La Jolla, CA, USA. mtuszynski@ucsd.edu.ORCID http://orcid.org/0000-0003-4182-1481
University of California San Diego · USSan Francisco VA Medical Center · USUniversity of Michigan · US

Funding

Rapid 3D bioprinting of biomimetic vascularized tissue constructsR01EB021857 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHAOCHEN, DOKMECI, MEHMET REMZI · 2016 to 2019
$2.1M
JEOL JEM-1400Plus Transmission Electron MicroscopeS10OD023527 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FARQUHAR, MARILYN GIST · 2017 to 2017
$579k
Rapid 3D-printing of Multi-functional Adaptive Nerve ConduitsR21HD090662 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHAOCHEN · 2017 to 2018
$382k
NIBIB NIH HHS R01 EB021857NICHD NIH HHS R21 HD090662NIH HHS S10 OD023527RRD VA I01 RX002264
6 · The paper itself

Abstract

Current methods for bioprinting functional tissue lack appropriate biofabrication techniques to build complex 3D microarchitectures essential for guiding cell growth and promoting tissue maturation

Indexed as

BiomimeticsNerve RegenerationPrinting, Three-DimensionalAnimalsGreen Fluorescent ProteinsHumansNeural Stem CellsRatsSpinal Cord InjuriesTissue ScaffoldsGreen Fluorescent Proteins

Identifiers

PMID30643285
PMCPMC6559945
OpenAlexW2908359749

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.