ArticleNature immunology2019
Thymic regulatory T cells arise via two distinct developmental programs.
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Article in Nature immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers.
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147citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
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Who cites it
147 citing papers in PubMed, 221 citations in OpenAlex.
- Direct targeting of FOXP3 in Tregs with AZD8701, a novel antisense oligonucleotide to relieve immunosuppression in cancer.Journal for immunotherapy of cancer · 2022Trial
- Beyond immune suppression: regenerative programs in regulatory T cells.Cell insight · 2026Review
- Targeting FOXP3 and Regulatory T Cells in Systemic Lupus Erythematosus: Emerging Therapeutic Strategies and Clinical Prospects.Journal of cellular biochemistry · 2026Review
- Regulatory T cells in the skin: Origin, function, and plasticity.JID innovations : skin science from molecules to population health · 2026Review
- Impact of Chronic Infection-Induced Inflammation on TREG Cell Homeostasis.European journal of immunology · 2026Article
- Extracellular Vesicles as Immunomodulatory Mediators in Angiogenic-Osteogenic Coupling: Mechanistic Insights and Therapeutic Potential.Advanced healthcare materials · 2026Review
- FGF21 induced by endoplasmic reticulum stress maintains medullary thymic epithelial cell function and central immune tolerance.Science advances · 2026Article
- Rag1-based time-stamp tracing of T-cell developmental origins.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- TCR signal strength during positive selection shapes CD25 expression patterns on thymically derived regulatory T cells.bioRxiv : the preprint server for biology · 2026Article
- Protocol for identifying recirculating thymic regulatory T cells and characterizing the role of Eos in their function using scRNA-seq and TCR-seq.STAR protocols · 2026Article
- From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology.Immunological reviews · 2026Review
- KLF2 controls thymic epithelial cell homeostasis, impacting regulatory T cell development and immune tolerance.iScience · 2026Article
- Claudin 1-mediated positioning of DC1 to mTECs is essential for maintenance of central tolerance.The Journal of experimental medicine · 2026Article
- The differentiation and function of heterogeneous thymic dendritic cell subsets require signals provided by distinct thymocyte cell types.Nature immunology · 2026Article
- Regulatory T Cell Heterogeneity in the Steady State and Tumor.Immune network · 2026Review
- Eos plays a critical role in Treg homeostasis and modulates the function of recirculating thymic Tregs in the control of Treg development.Cell reports · 2026Article
- Dot1L licenses DNA demethylation to establish regulatory T cell identity.bioRxiv : the preprint server for biology · 2026Article
- Multifaceted regulation of thymic tolerance by pattern recognition cascades.Frontiers in immunology · 2026Review
- [Guardians of Immune Tolerance: Regulatory T Cells].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Review
- Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells.Nature immunology · 2025Article
87 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
23 authors at 8 institutions in 1 country.
David L OwenCenter for Immunology, Masonic Cancer Center, and the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Shawn A MahmudCenter for Immunology, Masonic Cancer Center, and the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Louisa E SjaastadCenter for Immunology, Masonic Cancer Center, and the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Jason B WilliamsSection of Rheumatology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
Justin A SpanierCenter for Immunology, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Dimitre R SimeonovDepartment of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-1693-8664
Roland RuscherCenter for Immunology, Masonic Cancer Center, and the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Weishan HuangDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0002-1330-1131
Irina ProektDiabetes Center, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-3818-1102
Corey N MillerDiabetes Center, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-1291-0074
Can HekimCenter for Immunology, Masonic Cancer Center, and the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Jonathan C JeschkeSection of Rheumatology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
Praful AggarwalSection of Genomic Pediatrics, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
Ulrich BroeckelSection of Genomic Pediatrics, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
Rebecca S LaRueSupercomputing Institute for Advanced Computational Research, University of Minnesota, Minneapolis, MN, USA.
Christine M HenzlerSupercomputing Institute for Advanced Computational Research, University of Minnesota, Minneapolis, MN, USA.
Maria-Luisa AlegreSection of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, USA.
Mark S AndersonDiabetes Center, University of California San Francisco, San Francisco, CA, USA.
Avery AugustDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0003-4968-3415
Alexander MarsonDepartment of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.
Ye ZhengNomis Foundation Laboratories for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-5012-4309
Calvin B WilliamsSection of Rheumatology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
Michael A FarrarCenter for Immunology, Masonic Cancer Center, and the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA. farra005@umn.edu.ORCID http://orcid.org/0000-0002-5569-0366
University of Minnesota Medical Center · USMedical College of Wisconsin · USUniversity of California, San Francisco · USUniversity of Minnesota · USCornell University · USLouisiana State University · USSalk Institute for Biological Studies · USUniversity of Chicago · US
Funding
Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Douglas Yee · 1998 to 2026
$100.4MViral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Ye Zheng · 1985 to 2026
$82.8MType I interferons in tolerance in the steady stateP01AI035296 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HOGQUIST, KRISTIN A. · 1993 to 2023
$31.1MULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI LIU, CAMBRIAN YANGSHAO · 1990 to 2025
$29.8MT cell mechanisms that distinguish robust tolerance from metastable allograft acceptance and failed tolerance (Project 2)P01AI097113 · NIAID · UNIVERSITY OF CHICAGO · PI Maria-Luisa Alegre, Anita S Chong · 2012 to 2026
$23.8MMOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0MPREDOCTORAL TRAINING IN BIOMEDICAL SCIENCEST32GM008568 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANSEL, KARL MARK · 1995 to 2019
$6.3MIMMUNOLOGY TRAINING PROGRAMT32AI007313 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Carla Rothlin · 1989 to 2026
$5.7MProtein CoreP30GM110760 · NIGMS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI KOUSOULAS, KONSTANTIN G · 2014 to 2018
$5.6MTreg development and function controlled by cis-regulatory circuitsR01AI107027 · NIAID · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI ZHENG, YE · 2014 to 2022
$5.0MRegulatory T Cells in Alzheimer's DiseaseR01AI124512 · NIAID · UNIVERSITY OF MINNESOTA · PI FARRAR, MICHAEL ARCHIBALD · 2016 to 2025
$4.5MImpact of Microbiota on Alloimmune Responses in TransplantationR01AI115716 · NIAID · UNIVERSITY OF CHICAGO · PI ALEGRE, MARIA-LUISA · 2015 to 2024
$4.3MNCI NIH HHS P30 CA014195NCI NIH HHS P30 CA077598NCI NIH HHS R01 CA151845NCI NIH HHS R01 CA154998NCI NIH HHS R01 CA185062NIAID NIH HHS P01 AI035296NIAID NIH HHS P01 AI097113NIAID NIH HHS R01 AI061165NIAID NIH HHS R01 AI085090NIAID NIH HHS R01 AI106791NIAID NIH HHS R01 AI107027NIAID NIH HHS R01 AI115716NIAID NIH HHS R01 AI120701NIAID NIH HHS R01 AI124512NIAID NIH HHS R21 AI108958NIAID NIH HHS R21 AI126814NIAID NIH HHS R21 AI129422NIAID NIH HHS R37 AI097457NIAID NIH HHS R56 AI061165NIAID NIH HHS R56 AI113138NIAID NIH HHS T32 AI007313NIAID NIH HHS T32 AI007334NIAID NIH HHS U24 AI118635NIDDK NIH HHS DP3 DK111914NIDDK NIH HHS F30 DK096844NIDDK NIH HHS P30 DK042086NIGMS NIH HHS P30 GM110760NIGMS NIH HHS T32 GM008568
Abstract
The developmental programs that generate a broad repertoire of regulatory T cells (T
Indexed as
AnimalsAutoantigensCell DifferentiationColitisDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalForkhead Transcription FactorsFreund's AdjuvantHumansImmune ToleranceInterleukin-2 Receptor alpha SubunitLymphoid Progenitor CellsMiceMice, TransgenicMycobacterium tuberculosisMyelin-Oligodendrocyte GlycoproteinAutoantigensForkhead Transcription FactorsFoxp3 protein, mouseFreund's AdjuvantIl2ra protein, mouseInterleukin-2 Receptor alpha SubunitMyelin-Oligodendrocyte Glycoproteinmyelin oligodendrocyte glycoprotein (35-55)Peptide Fragments
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.