ArticleNature immunology2019
The Ca
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In one paragraph
Article in Nature immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 234 papers.
0numbers the graph read from it
0cells of the map it votes in
234citing papers in PubMed
11.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
234 citing papers in PubMed, 348 citations in OpenAlex.
- FOXM1 drives cisplatin resistance in ovarian cancer through STIM1-mediated SOCE and STAT1 activation.Molecular therapy. Oncology · 2026Article
- Ion-GPS nanocapsules activate calcium-permeable gates in inflammatory microglia for nerve function recovery.Bioactive materials · 2026Article
- cGAS-STING signaling in the anterior cingulate cortex modulates electroacupuncture analgesia in a rat neuropathic pain model.The Korean journal of pain · 2026Article
- The cGAS-STING/MITA pathway in innate antiviral immunity and beyond.Cell insight · 2026Review
- The cGAS-STING pathway in inflammaging and neuroinflammation.Science China. Life sciences · 2026Review
- Orai1-mediated CaExperimental & molecular medicine · 2026Article
- Mitochondrial-endoplasmic reticulum interactions in lung diseases.Cell death & disease · 2026Review
- Article
- Magnetic Reprogramming of Macrophages Stimulates Phagocytosis of Breast Cancer Cells via a TRPC1-STING Inflammatory Axis.Smart medicine · 2026Article
- Unraveling new functions of the Ca2+ sensor STIM1 in cell signaling.Biochemical Society transactions · 2026Review
- Mechanistic insights and therapeutic potential of targeting the cGAS-STING pathway in neurodegenerative diseases.Journal of neuroinflammation · 2026Review
- Viral Mimicry of Alzheimer's Disease: Innate Sensing of Self-Nucleic Acids as a Driver of Glial Senescence.Journal of molecular neuroscience : MN · 2026Review
- Article
- USP39 promotes antiviral defense through post-transcriptional control of RIG-I and stabilization of STING.PLoS biology · 2026Article
- Non-canonical STING activation by calcium influx paired to endoplasmic reticulum stress.Cell communication and signaling : CCS · 2026Article
- Article
- Low-dose radiotherapy remodels the tumor immune microenvironment via the cGAS-STING pathway: mechanisms, challenges, and combination therapy strategies.Molecular cancer · 2026Review
- Emerging Mechanistic Roles of STING Signaling in Kidney Diseases.The American journal of pathology · 2026Review
- An additional site mutation in MITA/STING gain-of-function mutants abolishes the autoimmune SAVI phenotypes and directs a therapeutic strategy.Cell insight · 2026Article
- Stimulator of Interferon Genes Is a Fine-Tuner, but Not a Prime Mover, of Kidney Inflammation.The American journal of pathology · 2026Article
174 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 3 countries.
Sonal SrikanthDepartment of Physiology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA. ssrikanth@mednet.ucla.edu.ORCID http://orcid.org/0000-0002-3034-095X
Jin Seok WooDepartment of Physiology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Beibei WuDepartment of Physiology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Yasser M El-SherbinyNational Institute for Health Research-Leeds Biomedical Research Centre and Leeds Institute of Rheumatic and Musculoskeletal Medicine, Wellcome Trust Brenner Building, St James's University Hospital, Leeds, UK.ORCID http://orcid.org/0000-0003-4791-3475
Jennifer LeungDepartment of Physiology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Koollawat ChupraditDivision of Hematology-Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Laura RiceLeeds Institute of Biomedical and Clinical Sciences, University of Leeds, Wellcome Trust Brenner Building, St James's University Hospital, Leeds, UK.
Gil Ju SeoDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Guillaume CalmettesDepartment of Medicine (Cardiology), David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Chandran RamakrishnaDepartment of Molecular Immunology, City of Hope Beckman Research Institute, Duarte, CA, USA.
Edouard CantinDepartment of Molecular Immunology, City of Hope Beckman Research Institute, Duarte, CA, USA.ORCID http://orcid.org/0000-0002-2352-710X
Dong Sung AnDivision of Hematology-Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Ren SunDepartment of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA, USA.
Ting-Ting WuDepartment of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA, USA.
Jae U JungDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-4559-8774
Sinisa SavicNational Institute for Health Research-Leeds Biomedical Research Centre and Leeds Institute of Rheumatic and Musculoskeletal Medicine, Wellcome Trust Brenner Building, St James's University Hospital, Leeds, UK.ORCID http://orcid.org/0000-0001-7910-0554
Yousang GwackDepartment of Physiology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA. ygwack@mednet.ucla.edu.ORCID http://orcid.org/0000-0002-2821-9245
University of California, Los Angeles · USCity of Hope · USUniversity of Southern California · USMansoura University · EGSt James's University Hospital · GBUniversity of Leeds · GB
Funding
Roles of the K3 and K5 in KSHV Persistence and PathogenesisP01CA180779 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JUNG, JAE U · 2013 to 2017
$7.3MMolecular Basis of KSHV oncogenesisR35CA200422 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JUNG, JAE U · 2016 to 2022
$6.1MRole of viral BCI-2 mediated anti-apoptosis and-autophagyR01AI073099 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JUNG, JAE U · 2007 to 2017
$4.3MKSHV Epigenetic RegulationR01DE023926 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JUNG, JAE U · 2013 to 2024
$4.2MSFTSV nonstructural protein NSs-mediated immunopathogenesisR01AI140705 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JUNG, JAE U · 2018 to 2022
$4.2MNovel regulators of store-operated Ca2+ entry in immune systemsR01AI083432 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GWACK, YOUSANG · 2009 to 2020
$3.8MTRIM9-mediated anti-viral immune pathwayR01AI116585 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JUNG, JAE U · 2015 to 2019
$2.3MRole of autophagy for Zika virus lifecycleR21AI129496 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JUNG, JAE U · 2017 to 2018
$454kRegulation of lymphangiogenesis by KSHV vIRF3R21DE027888 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JUNG, JAE U · 2018 to 2019
$451kRole of histone demethylase Kdm3C in age-associated oral and systemic inflammationR21DE028269 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GWACK, YOUSANG, KANG, MO K. · 2018 to 2019
$429kDistinct functions of Orai1 and Orai2 in naive and effector helper T cellsR21AI130653 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SRIKANTH, SONAL · 2017 to 2018
$424kNCI NIH HHS P01 CA180779NCI NIH HHS R35 CA200422NIAID NIH HHS R01 AI073099NIAID NIH HHS R01 AI083432NIAID NIH HHS R01 AI116585NIAID NIH HHS R01 AI140705NIAID NIH HHS R21 AI129496NIAID NIH HHS R21 AI130653NIDCR NIH HHS R01 DE023926NIDCR NIH HHS R21 DE027888NIDCR NIH HHS R21 DE028269
Abstract
Stimulator of interferon genes (STING) is an endoplasmic reticulum (ER) signaling adaptor that is essential for the type I interferon response to DNA pathogens. Aberrant activation of STING is linked to the pathology of autoimmune and autoinflammatory diseases. The rate-limiting step for the activation of STING is its translocation from the ER to the ER-Golgi intermediate compartment. Here, we found that deficiency in the Ca
Indexed as
AnimalsChild, PreschoolChlorocebus aethiopsDisease Models, AnimalDNA, ViralEndoplasmic ReticulumFibroblastsGene Knockout TechniquesHEK293 CellsHerpes SimplexHerpesvirus 1, HumanHumansImmunity, InnateInterferon Type IJurkat CellsMacrophagesDNA, ViralInterferon Type IMembrane ProteinsNeoplasm ProteinsSTIM1 protein, humanStim1 protein, mouseSTING1 protein, humanSting1 protein, mouseSTING ProteinStromal Interaction Molecule 1
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.