Evidence map›Paper›PMID 30643251›Full record

SynthesisNature genetics2019

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.

Mengzhen Liu, Yu Jiang, Robbee Wedow, Yue Li, David M Brazel, Fang Chen, Gargi Datta, Jose Davila-Velderrain, Daniel McGuire, Chao Tian and 115 more

Open access · greenAbstract readMeta-Analysis
In one paragraph

Synthesis in Nature genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,184 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,184citing papers in PubMed, 9 pooled it
155.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,184 citing papers in PubMed, 9 syntheses or guidelines pooled it, 2,114 citations in OpenAlex.

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  4. Inflammatory cytokines are associated with stroke and risk factors of cerebrovascular diseases: a Mendelian randomization study.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
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1,124 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

125 authors at 20 institutions in 11 countries.

Mengzhen LiuDepartment of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA.
Yu JiangDepartment of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA, USA.
Robbee WedowInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.ORCID http://orcid.org/0000-0002-3108-7087
Yue LiComputer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-1163-3634
David M BrazelInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.ORCID http://orcid.org/0000-0001-5361-2498
Fang ChenDepartment of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA, USA.ORCID http://orcid.org/0000-0003-3108-8204
Gargi DattaDepartment of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-1314-7824
Jose Davila-VelderrainComputer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA.
Daniel McGuireDepartment of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA, USA.
Chao Tian23andMe, Inc., Mountain View, CA, USA.
Xiaowei ZhanQuantitative Biomedical Research Center, Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
23andMe Research Team
HUNT All-In Psychiatry
Hélène ChoquetDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.ORCID http://orcid.org/0000-0001-9839-8667
Anna R DochertyDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Johanna R FoersterDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Lars G FritscheDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-2110-1690
Maiken Elvestad GabrielsenK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
Scott D GordonGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Jeffrey HaesslerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Jouke-Jan HottengaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Hongyan HuangProgram in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Seon-Kyeong JangDepartment of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA.
Philip R JansenDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0003-1550-2444
Yueh LingDepartment of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA, USA.
Reedik MägiEstonian Genome Center, University of Tartu, Tartu, Estonia.
Nana MatobaLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama City, Japan.ORCID http://orcid.org/0000-0001-5329-0134
George McMahonDepartment of Population Health Science, Bristol Medical School, Oakfield Grove, Bristol, UK.
Antonella MulasIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Italy.
Valeria OrrùIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Italy.
Teemu PalviainenInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-7847-8384
Anita PanditDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Gunnar W ReginssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Anne Heidi SkogholtK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
Jennifer A SmithSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-3575-5468
Amy E TaylorDepartment of Population Health Science, Bristol Medical School, Oakfield Grove, Bristol, UK.
Constance TurmanProgram in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Gonneke WillemsenDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Hannah YoungDepartment of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA.
Kendra A YoungDepartment of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-8664-7635
Gregory J M ZajacDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-6411-9666
Wei ZhaoDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Wei ZhouDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Gyda BjornsdottirdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Jason D BoardmanInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
Michael BoehnkeDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-6442-7754
Dorret I BoomsmaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Chu ChenDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Francesco CuccaIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Italy.ORCID http://orcid.org/0000-0002-7414-1995
Gareth E DaviesAvera Institute for Human Genetics, Sioux Falls, SD, USA.
Charles B EatonDepartment of Family Medicine and Community Health, Alpert Medical School, Brown University, Providence, RI, USA.
Marissa A EhringerInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
Tõnu EskoThe Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-1982-6569
Edoardo FiorilloIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Italy.
Nathan A GillespieDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Daniel F GudbjartssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-5222-9857
Toomas HallerEstonian Genome Center, University of Tartu, Tartu, Estonia.
Kathleen Mullan HarrisDepartment of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Andrew C HeathDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.
John K HewittInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
Ian B HickieBrain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
John E HokansonDepartment of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Christian J HopferInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
David J HunterProgram in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
William G IaconoDepartment of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA.
Eric O JohnsonFellows Program, RTI International, Research Triangle Park, NC, USA.
Yoichiro KamataniLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama City, Japan.ORCID http://orcid.org/0000-0001-8748-5597
Sharon L R KardiaDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Matthew C KellerInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.ORCID http://orcid.org/0000-0002-6075-9882
Manolis KellisComputer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Peter KraftProgram in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Kenneth S KrauterInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
Markku LaaksoDepartment of Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Penelope A LindPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Anu LoukolaInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Sharon M LutzDepartment of Biostatistics and Bioinformatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Pamela A F MaddenDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.
Nicholas G MartinGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-4069-8020
Matt McGueDepartment of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA.
Matthew B McQueenInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
Sarah E MedlandPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu, Estonia.
Karen L MohlkeDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-6721-153X
Jonas B NielsenDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-6654-2852
Yukinori OkadaLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama City, Japan.ORCID http://orcid.org/0000-0002-0311-8472
Ulrike PetersDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-5666-9318
Tinca J C PoldermanDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0001-5564-301X
Danielle PosthumaDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0001-7582-2365
Alexander P ReinerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
John P RiceDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Eric RimmDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Richard J RoseDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
Valgerdur RunarsdottirSAA-National Center of Addiction Medicine, Vogur Hospital, Reykjavik, Iceland.
Michael C StallingsInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
Alena StančákováDepartment of Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0002-1375-0252
Hreinn StefanssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Khanh K ThaiDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Hilary A TindleDepartment of Medicine, Vanderbilt University, Nashville, TN, USA.
Thorarinn TyrfingssonSAA-National Center of Addiction Medicine, Vogur Hospital, Reykjavik, Iceland.
Tamara L WallDepartment of Psychiatry, University of California, San Diego, San Diego, CA, USA.
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Constance WeisnerDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
John B WhitfieldGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Bendik Slagsvold WinsvoldFORMI and Department of Neurology, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0003-4171-8919
Jie YinDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Luisa ZuccoloDepartment of Population Health Science, Bristol Medical School, Oakfield Grove, Bristol, UK.
Laura J BierutDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Kristian HveemK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
James J LeeDepartment of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-6547-5128
Marcus R MunafòMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-4049-993X
Nancy L SacconeDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Cristen J WillerDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-5645-4966
Marilyn C CornelisDepartment of Preventative Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Sean P DavidDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-4922-2603
David A Hinds23andMe, Inc., Mountain View, CA, USA.ORCID http://orcid.org/0000-0002-4911-803X
Eric JorgensonDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.ORCID http://orcid.org/0000-0002-5829-8191
Jaakko KaprioInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-3716-2455
Jerry A StitzelInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
Kari StefanssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0003-1676-864X
Thorgeir E ThorgeirssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Gonçalo AbecasisDepartment of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Dajiang J LiuDepartment of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA, USA. dajiang.liu@psu.edu.ORCID http://orcid.org/0000-0001-6553-858X
Scott VriezeDepartment of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA. vrieze@umn.edu.ORCID http://orcid.org/0000-0003-3861-7930
University of Minnesota · USdeCODE Genetics (Iceland) · ISUniversity of Michigan · USHarvard University · USPennsylvania State University · USKaiser Permanente · USUniversity of Colorado Boulder · USBroad Institute · USUniversity of Helsinki · FIWashington University in St. Louis · USFred Hutch Cancer Center · USUniversity of North Carolina at Chapel Hill · USNorwegian University of Science and Technology · NOUniversity of Eastern Finland · FIUniversity of Washington · US23andMe (United States) · USInstitute of Genetic and Biomedical Research · ITNorthwestern University · USOslo University Hospital · NOQIMR Berghofer Medical Research Institute · AU

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
Wave IV Data CollectionP01HD031921 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HARRIS, KATHLEEN MULLAN · 1994 to 2020
$86.1M
Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Metabolomic signatures of empysema and COPD progression in the COPDGene cohortR01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2012 to 2016
$31.1M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
University of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4M
Identifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6M
Targeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3M
The Effects of Cannabis Legalization and Persistent Use: A Longitudinal Study of Two Twin CohortsR01DA042755 · NIDA · UNIVERSITY OF COLORADO DENVER · PI Jarrod Martin Ellingson, SOO H RHEE · 2017 to 2026
$9.9M
Genetic epidemiology of rare and regulatory variants for metabolic traitsR01DK093757 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2011 to 2026
$8.2M
Identifying Genes for Type 2 Diabetes:FUSIONR01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2003 to 2025
$6.7M
Medical Research Council G0902144Medical Research Council MC_UU_00011/7Medical Research Council MC_UU_12013/1Medical Research Council MR/K023195/1NHGRI NIH HHS R01 HG008983NHGRI NIH HHS T32 HG000040NHLBI NIH HHS K01 HL125858NHLBI NIH HHS R01 HL089897NHLBI NIH HHS R01 HL119443NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NIAAA NIH HHS R01 AA023974NIAAA NIH HHS R21 AA021223NIA NIH HHS U01 AG009740NICHD NIH HHS P01 HD031921NICHD NIH HHS P2C HD066613NICHD NIH HHS R03 HD097630NIDA NIH HHS R01 DA034076NIDA NIH HHS R01 DA036583NIDA NIH HHS R01 DA037904NIDA NIH HHS R01 DA042755NIDA NIH HHS R21 DA040177NIDA NIH HHS U01 DA046413NIDCD NIH HHS R03 DC013373NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK062370NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK093757NIDDK NIH HHS T32 DK091317NIDDK NIH HHS U01 DK062370NIGMS NIH HHS R01 GM126479NIH HHS R03 OD032630NIH HHS S10 OD020069NIMH NIH HHS K01 MH109765NIMH NIH HHS R01 MH123619
6 · The paper itself

Abstract

Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders

Indexed as

Alcohol DrinkingFemaleGenetic VariationGenome-Wide Association StudyHumansMaleMiddle AgedNicotianaPhenotypeRiskSmokingTobacco Use Disorder

Identifiers

PMID30643251
PMCPMC6358542
OpenAlexW2909598358

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.