ArticleNature genetics2019
PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia.
Registry-linked trialAbstract read
In one paragraph
Article in Nature genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00137111 (Total XV - Total Therapy Study XV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia), which is not on this map. Cited by 363 papers.
0numbers the graph read from it
0cells of the map it votes in
363citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Total XV - Total Therapy Study XV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia
Who cites it
363 citing papers in PubMed.
- Association of leukemic molecular profile with efficacy of inotuzumab ozogamicin in adults with relapsed/refractory ALL.Blood advances · 2024Trial
- Optical genome mapping enhanced by refined variant interpretation in pediatric acute lymphoblastic leukemia.The Journal of pathology · 2026Article
- PAX5 modulates vascularization and contributes to neuroendocrine lineage transition during carcinoma progression.The Journal of clinical investigation · 2026Article
- The machine-learning classifier ALLCatchR2 identifies 20 T-ALL subtypes across cohorts and age groups.HemaSphere · 2026Article
- A genomic and epigenomic lens into the biology of acute lymphoblastic leukaemia.Nature reviews. Cancer · 2026Review
- Tumor-induced dendritic cell deregulation perturbs T cell proliferation and predicts clinical outcome in acute lymphoblastic leukemia.Cell reports. Medicine · 2026Article
- Article
- Pitfalls and Challenges in the Detection of ZNF384 Rearrangements by Fluorescence in Situ Hybridization.Genes, chromosomes & cancer · 2026Article
- FATP2-mediated lipid metabolism enhances chimeric antigen receptor T-cell therapy resistance in B-cell acute lymphoblastic leukemia.Leukemia · 2026Article
- Proteomic Profiling of Bone Marrow Aspirates from Patients with Methotrexate- and Vincristine-Resistant B-Cell Acute Lymphoblastic Leukemia: A Retrospective Analysis.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Developmental timing distinguishes pediatric and adult cancers through retention and rewiring mechanisms.Nature communications · 2026Review
- Article
- Multi-omics analysis of pediatric minimally differentiated acute myeloid leukemia reveals RUNX1-driven stemness and chemoresistance.Leukemia · 2026Article
- Clinical features and initial treatment outcomes of pediatric B-cell acute lymphoblastic leukemia with P2RY8::CRLF2 fusion positivity: a case series.Translational pediatrics · 2026Article
- Transcriptomic remodeling of bone marrow mesenchymal stromal cells in pediatric B-cell acute lymphoblastic leukemia: a four-gene signature.Translational pediatrics · 2026Article
- Deep learning based individualized cross-platform molecular subtype classification of B-lineage acute lymphoblastic leukemia.NPJ precision oncology · 2026Article
- Article
- A novelBlood science (Baltimore, Md.) · 2026Article
- Integrated Genomic Profiling of Pediatric Acute Lymphoblastic Leukemia: Genomic Landscape, Risk Stratification and Association of RAS Pathway Mutations with Early Treatment Response.International journal of molecular sciences · 2026Article
- The landscape of structural variation in pediatric cancer.Cancer cell · 2026Article
303 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
60 authors.
Zhaohui GuDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Michelle L ChurchmanDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Kathryn G RobertsDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Ian MooreDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Xin ZhouDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Joy NakitandweDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Kohei HagiwaraDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Stephane PelletierDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-1127-0212
Sebastien GingrasDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Hartmut BernsDepartment of Transgenic/Gene Knockout Shared Resource, St. Jude Children's Research Hospital, Memphis, TN, USA.
Debbie Payne-TurnerDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Ashley HillDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Ilaria IacobucciDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Lei ShiDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Stanley PoundsDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-9167-2114
Cheng ChengDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Deqing PeiDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Chunxu QuDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Scott NewmanDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Meenakshi DevidasDepartment of Biostatistics, University of Florida, Gainesville, FL, USA.
Yunfeng DaiDepartment of Biostatistics, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0003-3961-4766
Shalini C ReshmiInstitute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
Julie Gastier-FosterInstitute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
Elizabeth A RaetzDivision of Pediatric Hematology-Oncology, New York University, New York, NY, USA.
Michael J BorowitzDivision of Hematologic Pathology, Johns Hopkins University, Baltimore, MD, USA.
Brent L WoodDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
William L CarrollPerlmutter Cancer Center, NYU-Langone Health, New York, NY, USA.
Patrick A Zweidler-McKayImmunoGen, Inc, Waltham, MA, USA.
Karen R RabinBaylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-4081-8195
Leonard A MattanoHARP Pharma Consulting, Mystic, CT, USA.
Kelly W MaloneyUniversity of Colorado School of Medicine and Children's Hospital, Aurora, CO, USA.
Alessandro RambaldiHematology and Bone Marrow Transplant Unit, Ospedale Papa Giovanni XXIII, Bergamo, Italy.
Orietta SpinelliHematology and Bone Marrow Transplant Unit, Ospedale Papa Giovanni XXIII, Bergamo, Italy.
Jerald P RadichFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Mark D MindenPrincess Margaret Cancer Centre, University Health Network, Toronto, Canada.
Jacob M RoweHematology, Shaare Zedek Medical Center, Jerusalem, Israel.
Selina LugerAbramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
Mark R LitzowDivision of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Martin S TallmanMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Janis RacevskisCancer Center, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Yanming ZhangCytogenetics Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ravi BhatiaDivision of Hematology-Oncology, University of Birmingham, Birmingham, AL, USA.
Jessica KohlschmidtComprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Krzysztof MrózekComprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Clara D BloomfieldComprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-5465-7591
Wendy StockUniversity of Chicago Medical Center, Chicago, IL, USA.
Steven KornblauDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Hagop M KantarjianDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Marina KonoplevaDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Williams E EvansDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-9333-5322
Sima JehaDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Ching-Hon PuiDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Jun YangDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-0770-9659
Elisabeth PaiettaCancer Center, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
James R DowningDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Mary V RellingDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.
Jinghui ZhangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Mignon L LohDepartment of Pediatrics, UCSF Benioff Children's Hospital and the Helen Diller Family, San Francisco, CA, USA.
Stephen P HungerChildren's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Charles G MullighanDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA. charles.mullighan@stjude.org.ORCID http://orcid.org/0000-0002-1871-1850
Funding
NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6MX-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MTumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8MProject-006U10CA180820 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI Peter J ODwyer, MITCHELL D. SCHNALL · 2014 to 2026
$167.6MViral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MCOG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8MTranslational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3MECOG-ACRIN Biospecimen Bank to Support NCTNU24CA196172 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI STANLEY R. HAMILTON, Scott D Jewell · 2015 to 2026
$41.1MCPML - Project 3: Genome-wide Studies of Adverse EffectsP50GM115279 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI RELLING, MARY V · 2015 to 2019
$15.1MTranslating genomic discoveries to improved outcomes for high risk acute leukemiaR35CA197695 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Charles G Mullighan · 2017 to 2026
$11.4MMontefiore Academic Community NCORP ProgramUG1CA189859 · NCI · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI Balazs Halmos, Della Makower · 2014 to 2026
$10.8MNaional Cancer Institute, Naitonal Clinical Trials Network U10 Lead Academic SiteU10CA180790 · NCI · MAYO CLINIC ROCHESTER · PI ALBERTS, STEVEN R, BOUGHEY, JUDY CAROLINE · 2014 to 2018
$6.6MNCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016058NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA021765NCI NIH HHS R35 CA197695NCI NIH HHS RC1 CA145707NCI NIH HHS U10 CA180790NCI NIH HHS U10 CA180791NCI NIH HHS U10 CA180820NCI NIH HHS U10 CA180886NCI NIH HHS U10 CA180899NCI NIH HHS U24 CA196172NCI NIH HHS UG1 CA189859NCI NIH HHS UG1 CA233332NIGMS NIH HHS P50 GM115279
Abstract
Recent genomic studies have identified chromosomal rearrangements defining new subtypes of B-progenitor acute lymphoblastic leukemia (B-ALL), however many cases lack a known initiating genetic alteration. Using integrated genomic analysis of 1,988 childhood and adult cases, we describe a revised taxonomy of B-ALL incorporating 23 subtypes defined by chromosomal rearrangements, sequence mutations or heterogeneous genomic alterations, many of which show marked variation in prevalence according to age. Two subtypes have frequent alterations of the B lymphoid transcription-factor gene PAX5. One, PAX5alt (7.4%), has diverse PAX5 alterations (rearrangements, intragenic amplifications or mutations); a second subtype is defined by PAX5 p.Pro80Arg and biallelic PAX5 alterations. We show that p.Pro80Arg impairs B lymphoid development and promotes the development of B-ALL with biallelic Pax5 alteration in vivo. These results demonstrate the utility of transcriptome sequencing to classify B-ALL and reinforce the central role of PAX5 as a checkpoint in B lymphoid maturation and leukemogenesis.
Indexed as
Acute DiseaseAdolescentAdultAgedAnimalsChildChild, PreschoolChromosomesFemaleGene RearrangementHumansInfantMaleMiceMice, Inbred C57BLMiddle AgedPAX5 protein, humanPAX5 Transcription Factor
Identifiers
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Read underepoch 390
Registered trials
NCT00137111ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.