ArticleScientific reports2019
Association of functional dorsal attention network alterations with breast cancer and chemotherapy.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Diagnostic Accuracy of Machine-Learning Models on Predicting Chemo-Brain in Breast Cancer Survivors Previously Treated with Chemotherapy: A Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Attention Dysregulation in Breast Cancer Patients Following a Complementary Alternative Treatment Routine: A Double-Blind Randomized Trial.Integrative cancer therapiesTrial
- Functional brain network alterations linked to cancer-related cognitive impairment in breast cancer patients.The oncologist · 2026Article
- Characteristics of Cognitive Function and Brain Alterations in Pneumoconiosis: A Cross-Sectional Study.Health science reports · 2026Article
- Article
- Article
- Acute and long-term effects of chemotherapy on cognitive function among Indian breast cancer patients.Ecancermedicalscience · 2025Article
- Relationship between δ-catenin expression and whole-brain small-world network in breast cancer patients before chemotherapy.Scientific reports · 2024Article
- Preliminary validation of the Cognitive Affective Mindfulness Scale-Revised in cancer populations.Psycho-oncology · 2024Article
- Article
- A scoping review of cognitive assessment tools and domains for chemotherapy-induced cognitive impairments in cancer survivors.Frontiers in human neuroscience · 2023Article
- Detecting microstructural alterations of cerebral white matter associated with breast cancer and chemotherapy revealed by generalized q-sampling MRI.Frontiers in psychiatry · 2023Article
- Early alterations in cortical morphology after neoadjuvant chemotherapy in breast cancer patients: A longitudinal magnetic resonance imaging study.Human brain mapping · 2022Article
- Four decades of chemotherapy-induced cognitive dysfunction: comprehensive review of clinical, animal and in vitro studies, and insights of key initiating events.Archives of toxicology · 2022Review
- Cyclophosphamide and epirubicin induce high apoptosis in microglia cells while epirubicin provokes DNA damage and microglial activation at sub-lethal concentrations.EXCLI journal · 2022Article
- Associations between disrupted functional brain network topology and cognitive impairment in patients with rectal cancer during chemotherapy.Frontiers in oncology · 2022Article
- Classification and Visualization of Chemotherapy-Induced Cognitive Impairment in Volumetric Convolutional Neural Networks.Journal of personalized medicine · 2021Article
- Comparison of functional dorsal attention network alterations in breast cancer survivors before and after chemotherapy.Medicine · 2021Article
- The association of genetic polymorphisms with neuroconnectivity in breast cancer patients.Scientific reports · 2021Article
- Cross-Sectional Characterization of Local Brain Network Connectivity Pre and Post Breast Cancer Treatment and Distinct Association With Subjective Cognitive and Psychological Function.Frontiers in neurology · 2021Article
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
Breast cancer is the most common cancer among women worldwide. Adjuvant chemotherapy has significantly reduced mortality but increased cognitive impairments, including attention function, making quality of life issues a crucial concern. This study enrolled nineteen breast cancer patients who were treated with standard chemotherapy within 6 months and 20 sex-matched healthy controls to investigate the brain effects of chemotherapy. All participants underwent resting-state functional magnetic resonance imaging (rs-fMRI) with mean fractional amplitude of low-frequency fluctuation (mfALFF) analysis and were correlated with neuropsychological tests, including the Mini-Mental State Examination (MMSE), the Cognitive and Affective Mindfulness Scale-Revised (CAMS-R), and the Impact of Event Scale-Revised (IES-R), to explore the possible underlying mechanism of cognitive alternations. We found increased mfALFF over the frontoparietal lobe and decreased mfALFF over the occipital lobe in the cancer patients compared with the healthy controls; the altered brain regions may be associated with the dorsal attention network (DAN) and may be explained by a compensatory mechanism. Both MMSE and CAMS-R scores showed a positive correlation with mfALFF in the occipital lobe but a negative correlation in the frontoparietal lobe. By contrast, IES-R scores showed a positive correlation with mfALFF in the frontoparietal lobe but a negative correlation in the occipital lobe. These alterations are potentially related to the effects of both chemotherapy and psychological distress. Future research involving a larger sample size of patients with breast cancer is recommended.
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