ArticleScientific reports2019
POGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33.
Open access · goldAbstract read
In one paragraph
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Genetic architecture of primary biliary cholangitis: strong evidence for HLA and non-HLA risk loci.Frontiers in immunology · 2025Pooled it
- rs57494551 increases CXCR5 expression and IgMJournal of gastroenterology · 2026Article
- TMEM39A acts as a novel profibrotic factor to activate hepatic stellate cells partially via the cell adhesion molecule signaling axis.Frontiers in cell and developmental biology · 2026Article
- rs10924104 in the expression enhancer motif of CD58 confers susceptibility to human autoimmune diseases.Human genetics · 2024Article
- NOTCH signalling - a core regulator of bile duct disease?Disease models & mechanisms · 2023Review
- Genome-Wide Association Study and Transcriptome of Japanese Patients with Developmental Dysplasia of the Hip Demonstrates an Association with the Ferroptosis Signaling Pathway.International journal of molecular sciences · 2023Article
- Review
- NovelFrontiers in immunology · 2023Article
- rs2013278 in the multiple immunological-trait susceptibility locus CD28 regulates the production of non-functional splicing isoforms.Human genomics · 2022Article
- APASL clinical practice guidance: the diagnosis and management of patients with primary biliary cholangitis.Hepatology international · 2022Article
- Regional heritability mapping identifies several novel loci (STAT4, ULK4, and KCNH5) for primary biliary cholangitis in the Japanese population.European journal of human genetics : EJHG · 2021Article
- rs1944919 on chromosome 11q23.1 and its effector genes COLCA1/COLCA2 confer susceptibility to primary biliary cholangitis.Scientific reports · 2021Article
- Structure, function, and pathology of protein O-glucosyltransferases.Cell death & disease · 2021Review
- Other Types of Glycosylation.Advances in experimental medicine and biology · 2021Article
- Genomics of Human Fibrotic Diseases: Disordered Wound Healing Response.International journal of molecular sciences · 2020Review
- Xylosyl Extension ofCells · 2020Article
- Integrated GWAS and mRNA Microarray Analysis Identified IFNG and CD40L as the Central Upstream Regulators in Primary Biliary Cholangitis.Hepatology communications · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
86 authors at 20 institutions in 1 country.
Yuki HitomiDepartment of Human Genetics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-6713-7875
Kazuko UenoDepartment of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Yosuke KawaiDepartment of Human Genetics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
Nao NishidaThe Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Japan.
Kaname KojimaDepartment of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Minae KawashimaJapan Science and Technology Agency (JST), Tokyo, Japan.
Yoshihiro AibaClinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.
Hitomi NakamuraClinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.
Hiroshi KounoHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Hirotaka KounoHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Hajime OhtaHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Kazuhiro SugiHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Toshiki NikamiHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Tsutomu YamashitaHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Shinji KatsushimaHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.ORCID http://orcid.org/0000-0003-0903-818X
Toshiki KomedaHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Keisuke ArioHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Atsushi NaganumaHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Masaaki ShimadaHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Noboru HirashimaHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Kaname YoshizawaHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Fujio MakitaHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Kiyoshi FurutaHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Masahiro KikuchiHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Noriaki NaeshiroHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Hironao TakahashiHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Yutaka ManoHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Haruhiro YamashitaHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Kouki MatsushitaHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Seiji TsunematsuHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Iwao YabuuchiHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Hideo NishimuraHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Yusuke ShimadaHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Kazuhiko YamauchiHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Tatsuji KomatsuHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Rie SugimotoHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Hironori SakaiHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Eiji MitaHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Masaharu KodaHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Yoko NakamuraHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Hiroshi KamitsukasaHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Takeaki SatoHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Makoto NakamutaHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.
Naohiko MasakiHeadquarters of PBC Research in NHO Study Group for Liver Disease in Japan (NHOSLJ), Clinical Research Center, NHO Nagasaki Medical Center, Omura, Japan.ORCID http://orcid.org/0000-0002-0631-8648
Hajime TakikawaDepartment of Medicine, Teikyo University School of Medicine, Tokyo, Japan.
Atsushi TanakaDepartment of Medicine, Teikyo University School of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0002-6358-5283
Hiromasa OhiraDepartment of Gastroenterology and Rheumatic Diseases, Fukushima Medical University of Medicine, Fukushima, Japan.
Mikio ZeniyaDepartment of Gastroenterology and Hepatology, Tokyo Jikei University School of Medicine, Tokyo, Japan.
Masanori AbeDepartment of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Matsuyama, Japan.
Shuichi KanekoDepartment of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.
Masao HondaDepartment of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.
Kuniaki AraiDepartment of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.
Teruko Arinaga-HinoDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan.
Etsuko HashimotoDepartment of Medicine and Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
Makiko TaniaiDepartment of Medicine and Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
Takeji UmemuraDepartment of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan.ORCID http://orcid.org/0000-0001-7985-919X
Satoru JoshitaDepartment of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan.ORCID http://orcid.org/0000-0002-6364-9654
Kazuhiko NakaoDepartment of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Tatsuki IchikawaDepartment of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Hidetaka ShibataDepartment of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Akinobu TakakiDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Satoshi YamagiwaDivision of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Masataka SeikeFaculty of Medicine, Oita University, Oita, Japan.
Shotaro SakisakaDepartment of Gastroenterology and Medicine, Fukuoka University School of Medicine, Fukuoka, Japan.
Yasuaki TakeyamaDepartment of Gastroenterology and Medicine, Fukuoka University School of Medicine, Fukuoka, Japan.ORCID http://orcid.org/0000-0001-7919-4407
Masaru HaradaThe Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Michio SenjuThe Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Osamu YokosukaDepartment of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Tatsuo KandaDepartment of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID http://orcid.org/0000-0002-9565-4669
Yoshiyuki UenoDepartment of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.ORCID http://orcid.org/0000-0001-5623-4250
Hirotoshi EbinumaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keio Graduate School of Medicine, Tokyo, Japan.
Takashi HimotoDepartment of Medical Technology, Kagawa Prefectural University of Health Sciences, Kagawa, Japan.
Kazumoto MurataThe Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Japan.
Shinji ShimodaDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Shinya NagaokaClinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.
Seigo AbiruClinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.
Atsumasa KomoriClinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.
Kiyoshi MigitaClinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.
Masahiro ItoClinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.
Hiroshi YatsuhashiClinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan.
Yoshihiko MaeharaDepartment of Surgery and Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Shinji UemotoDivision of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Norihiro KokudoNational Center for Global Health and Medicine, Tokyo, Japan.
Masao NagasakiDepartment of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Katsushi TokunagaDepartment of Human Genetics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
Minoru NakamuraClinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Omura, Japan. nakamura.minoru.mz@mail.hosp.go.jp.
Nagasaki Medical Center · JPKanazawa University · JPNagasaki University · JPNational Center for Global Health and Medicine · JPThe University of Tokyo · JPTohoku University · JPChiba University · JPFukuoka University · JPKyushu University · JPShinshu University · JPTeikyo University · JPTokyo Women's Medical University · JPUniversity of Occupational and Environmental Health Japan · JPEhime University · JPFukushima Medical University · JPJapan Science and Technology Agency · JPJikei University School of Medicine · JPKagawa Prefectural College of Health Sciences · JPKeio University · JPKurume University · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary biliary cholangitis (PBC) is a chronic and cholestatic autoimmune liver disease caused by the destruction of intrahepatic small bile ducts. Our previous genome-wide association study (GWAS) identified six susceptibility loci for PBC. Here, in order to further elucidate the genetic architecture of PBC, a GWAS was performed on an additional independent sample set, then a genome-wide meta-analysis with our previous GWAS was performed based on a whole-genome single nucleotide polymorphism (SNP) imputation analysis of a total of 4,045 Japanese individuals (2,060 cases and 1,985 healthy controls). A susceptibility locus on chromosome 3q13.33 (including ARHGAP31, TMEM39A, POGLUT1, TIMMDC1, and CD80) was previously identified both in the European and Chinese populations and was replicated in the Japanese population (OR = 0.7241, P = 3.5 × 10
Indexed as
Polymorphism, Single NucleotideAdultAgedAged, 80 and overFemaleGenome-Wide Association StudyGlucosyltransferasesHumansJapanLiver Cirrhosis, BiliaryMaleMiddle AgedYoung AdultGlucosyltransferasesPOGLUT1 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.