ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Reduced Structural Connectivity Between Left Auditory Thalamus and the Motion-Sensitive Planum Temporale in Developmental Dyslexia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05972200 (Probing the Efficacy of V5/MT Stimulation on Reading and Reading-related Measures in Children and Adolescents With Developmental Dyslexia), which is not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Probing the Efficacy of V5/MT Stimulation on Reading and Reading-related Measures in Children and Adolescents With Developmental Dyslexia
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Contributions of the left and right thalami to language: A meta-analytic approach.Brain structure & function · 2024Pooled it
- Rapid decay of perceptual memory in dyslexia.Trends in cognitive sciences · 2026Review
- Distinct Roles of Cerebellar Afferent and Efferent Fiber Tracts in Craniocervical Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Linking Attention Deficits to Difficulties in the Comprehension of Complex Syntax in Dyslexia.Dyslexia (Chichester, England) · 2026Article
- Denoising eye movement signals using a novel signal processing framework to preserve oculomotor integrity in dyslexia.Scientific reports · 2026Article
- Diffusion Magnetic Resonance Imaging Tractography Guides Investigation of the Zona Incerta: A Novel Target for Deep Brain Stimulation.Biological psychiatry · 2024Article
- Unraveling individual differences in learning potential: A dynamic framework for the case of reading development.Developmental cognitive neuroscience · 2024Review
- Investigating Dyslexia through Diffusion Tensor Imaging across Ages: A Systematic Review.Brain sciences · 2024Review
- Patterns of the left thalamus embedding into the connectome associated with reading skills in children with reading disabilities.Network neuroscience (Cambridge, Mass.) · 2024Article
- Fast frequency modulation is encoded according to the listener expectations in the human subcortical auditory pathway.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Article
- Olfactory Loss and Brain Connectivity after COVID-19: Structural Follow-Up at One Year.Neural plasticity · 2023Article
- Aberrant impulse control circuitry in obesity.Molecular psychiatry · 2022Article
- Structural and Functional Network-Level Reorganization in the Coding of Auditory Motion Directions and Sound Source Locations in the Absence of Vision.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Olfactory loss and brain connectivity after COVID-19.Human brain mapping · 2022Article
- Structural and functional brain changes in X-linked Charcot-Marie-Tooth disease: insights from a multimodal neuroimaging study.Neuroradiology · 2022Article
- Reduced Learning of Sound Categories in Dyslexia Is Associated with Reduced Regularity-Induced Auditory Cortex Adaptation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Animal models of developmental dyslexia.Frontiers in neuroscience · 2022Review
- Learning to read Chinese promotes two cortico-subcortical pathways: The development of thalamo-occipital and fronto-striatal circuits.Frontiers in neuroscience · 2022Article
- Development of thalamus mediates paternal age effect on offspring reading: A preliminary investigation.Human brain mapping · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Developmental dyslexia is characterized by the inability to acquire typical reading and writing skills. Dyslexia has been frequently linked to cerebral cortex alterations; however, recent evidence also points toward sensory thalamus dysfunctions: dyslexics showed reduced responses in the left auditory thalamus (medial geniculate body, MGB) during speech processing in contrast to neurotypical readers. In addition, in the visual modality, dyslexics have reduced structural connectivity between the left visual thalamus (lateral geniculate nucleus, LGN) and V5/MT, a cerebral cortex region involved in visual movement processing. Higher LGN-V5/MT connectivity in dyslexics was associated with the faster rapid naming of letters and numbers (RANln), a measure that is highly correlated with reading proficiency. Here, we tested two hypotheses that were directly derived from these previous findings. First, we tested the hypothesis that dyslexics have reduced structural connectivity between the left MGB and the auditory-motion-sensitive part of the left planum temporale (mPT). Second, we hypothesized that the amount of left mPT-MGB connectivity correlates with dyslexics RANln scores. Using diffusion tensor imaging-based probabilistic tracking, we show that male adults with developmental dyslexia have reduced structural connectivity between the left MGB and the left mPT, confirming the first hypothesis. Stronger left mPT-MGB connectivity was not associated with faster RANln scores in dyslexics, but was in neurotypical readers. Our findings provide the first evidence that reduced cortico-thalamic connectivity in the auditory modality is a feature of developmental dyslexia and it may also affect reading-related cognitive abilities in neurotypical readers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.