Evidence map›Paper›PMID 30643022›Full record

ArticleThe Journal of biological chemistry2019

A novel thyroid hormone receptor isoform, TRβ2-46, promotes SKP2 expression and retinoblastoma cell proliferation.

Zhengke Li, Dong-Lai Qi, Hardeep P Singh, Yue Zou, Binghui Shen, David Cobrinik

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Zhengke LiFrom The Vision Center and The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California 90027, LIZ01@mail.etsu.edu.
Dong-Lai QiFrom The Vision Center and The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California 90027.
Hardeep P SinghFrom The Vision Center and The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California 90027.
Yue ZouDepartment of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, and.
Binghui ShenDepartment of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope, Duarte, California 91010.
David CobrinikFrom The Vision Center and The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California 90027, dcobrinik@chla.usc.edu.ORCID 0000-0002-4478-2417
Children's Hospital of Los Angeles · USEast Tennessee State University · USCity of Hope · USUniversity of Southern California · US

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4M
Role of Nucleases in RNA Primer Removal and MutagenesisR01CA085344 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI SHEN, BINGHUI · 1999 to 2024
$7.7M
Successive responses to oncogenic aberrations in retinoblastoma genesis.R01CA137124 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI David Cobrinik · 2011 to 2026
$6.3M
RECOGNITION AND REPAIR OF UV DAMAGE TO HUMAN DNAR01CA086927 · NCI · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI ZOU, YUE · 2000 to 2011
$2.2M
ATR Isomerization in Cellular Responses to UV Damage of DNAR01CA219342 · NCI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI ZOU, YUE · 2017 to 2022
$1.8M
Human Specific Signaling Circuitry in Cone Precursor DevelopmentR01EY026661 · NEI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI COBRINIK, DAVID · 2016 to 2019
$1.7M
NCI NIH HHS P30 CA014089NCI NIH HHS R01 CA085344NCI NIH HHS R01 CA086927NCI NIH HHS R01 CA137124NCI NIH HHS R01 CA219342NEI NIH HHS R01 EY026661
6 · The paper itself

Abstract

Retinoblastoma is a childhood retinal tumor that develops from cone photoreceptor precursors in response to inactivating

Indexed as

AnimalsCell Line, TumorCell ProliferationGene Knockdown TechniquesHumansMiceNeoplasm ProteinsProtein IsoformsProtein StabilityRetinoblastomaS-Phase Kinase-Associated ProteinsThyroid Hormone Receptors betaNeoplasm ProteinsProtein IsoformsS-Phase Kinase-Associated ProteinsThyroid Hormone Receptors betacell cycleproliferationretinaretinoblastomathyroid hormone receptor β2translation initiationtumor cell biology

Identifiers

PMID30643022
PMCPMC6393598
OpenAlexW2910369691

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.