Trial reportProceedings of the National Academy of Sciences of the United States of America2019
Long-term effects of institutional rearing, foster care, and brain activity on memory and executive functioning.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Electroencephalogram activity related to psychopathological and neuropsychological symptoms in institutionalised minors: a systematic review.Acta neuropsychiatrica · 2025Pooled it
- A systematic review of the impact of intensive care admissions on post discharge cognition in children.European journal of pediatrics · 2021Pooled it
- Effects of foster care intervention and caregiving quality on the bidirectional development of executive functions and social skills following institutional rearing.Developmental science · 2023Trial
- Family-based care buffers the stress sensitizing effect of early deprivation on executive functioning difficulties in adolescence.Child development · 2023Trial
- Early deprivation alters structural brain development from middle childhood to adolescence.Science advances · 2022Trial
- Heightened sensitivity to the caregiving environment during adolescence: implications for recovery following early-life adversity.Journal of child psychology and psychiatry, and allied disciplines · 2021Trial
- Early parenting intervention accelerates inhibitory control development among CPS-involved children in middle childhood: A randomized clinical trial.Developmental science · 2021Trial
- The prospective association between stressful life events and inflammation among adolescents with a history of early institutional rearing.Development and psychopathology · 2020Trial
- Global deficits in executive functioning are transdiagnostic mediators between severe childhood neglect and psychopathology in adolescence.Psychological medicine · 2020Trial
- Adolescent cognitive control and mediofrontal theta oscillations are disrupted by neglect: Associations with transdiagnostic risk for psychopathology in a randomized controlled trial.Developmental cognitive neuroscience · 2020Trial
- Effects of adverse childhood experiences on behavior in adolescence: Insights from brain imaging and genetic risk.Developmental cognitive neuroscience · 2026Article
- Functional connectivity of youth in family-like residential care in Japan: Impact of reactive attachment disorder and disinhibited social engagement disorder symptoms.Neuroimage. Reports · 2026Article
- Early Life Adversity and Disordered Eating: Cognitive and Neural Mechanisms.Behavioral sciences (Basel, Switzerland) · 2025Review
- Social stress, cortisol awakening response and sex: association with hippocampus and amygdala volume.Biology of sex differences · 2025Article
- Perceived uncontrollability as a potential mechanism of parental child abuse predicting executive dysfunction in adulthood 18 years later: Replication across two studies.Developmental psychology · 2025Article
- Early adversity alters brain architecture and increases susceptibility to mental health disorders.Nature reviews. Neuroscience · 2025Review
- Associations Between Prenatal Maternal Stress and Infant Resting Brain Activity: A Preregistered Investigation.Developmental psychobiology · 2025Article
- Love on the developing brain: Maternal sensitivity and infants' neural responses to emotion in the dorsolateral prefrontal cortex.Developmental science · 2024Article
- Linking caregiving quality during infancy to brain activity in early childhood and later executive function.Developmental science · 2024Article
- Impacts of early deprivation on behavioral and neural measures of executive function in early adolescence.Brain and cognition · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Children experiencing psychosocial deprivation as a result of early institutional rearing demonstrate many difficulties with memory and executive functioning (EF). To date, there is scant evidence that foster care placement remediates these difficulties during childhood. The current study examined longitudinal trajectories of memory and EF from childhood to adolescence in the Bucharest Early Intervention Project, a randomized controlled trial of foster care for institutionally reared children. We demonstrate that both ever- and never-institutionalized children show age-related improvements on several measures of memory and EF from age 8 to 16. Distinct patterns were observed for different domains of functioning: (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.