ArticleProceedings of the National Academy of Sciences of the United States of America2019
Neural indicators of perceptual variability of pain across species.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed.
- Neurofeedback and attention modulate somatosensory alpha oscillations but not pain perception.PLoS biology · 2025Trial
- Individual variation in alpha neurofeedback training efficacy predicts pain modulation.NeuroImage. Clinical · 2020Trial
- Neurobiological mechanisms of TENS-induced analgesia.NeuroImage · 2019Trial
- Article
- Neural encoding of pain is robust within but unstable between individuals.PLoS biology · 2026Article
- Integrating multidimensional nociceptive-related cortical features for unsupervised assessment of anesthesia states in rats.iScience · 2026Article
- A two-system theory of sensory-evoked brain responses.Brain : a journal of neurology · 2026Review
- Temporal Interference Stimulation of the Motor Cortex Produces Frequency-Dependent Analgesia.bioRxiv : the preprint server for biology · 2026Article
- Dynamic expectation strength and precision shape human pain perception through shared and dissociable α-oscillatory mechanisms.PLoS biology · 2026Article
- Pulsed Radiofrequency Analgesia Alters EEG Spatiotemporal Dynamics: A Microstate-Based Exploratory Study.Pain and therapy · 2026Article
- Bridging the Gap in Pain Measurement with a Brain-Based Index.International journal of environmental research and public health · 2025Article
- A Replicable and Generalizable Neuroimaging-Based Indicator of Pain Sensitivity Across Individuals.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Abnormal Enhanced Gamma Synchronization in the Default Mode Network Associated With Chronic Pain.European journal of neurology · 2025Article
- Neural variability reliably encodes interindividual differences in the perception of pain intensity.PLoS biology · 2025Article
- A comprehensive EEG dataset of laser-evoked potentials for pain research.Scientific data · 2025Article
- Neural mechanisms underlying reduced nocifensive sensitivity in autism-associated Shank3 mutant dogs.Molecular psychiatry · 2025Article
- The Investigation of the Relationship Between Individual Pain Perception, Brain Electrical Activity, and Facial Expression Based on Combined EEG and Facial EMG Analysis.Journal of pain research · 2025Article
- EEG connectivity features associated with fibromyalgia revealed by machine learning.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Harnessing theta waves: tACS as a breakthrough in alleviating post-stroke chronic pain.Frontiers in neuroscience · 2025Review
- Parietal-specific activation reveals pain from inadequate levels of altitude acclimatization/ adaptation.PloS one · 2025Article
15 more citing papers are in PubMed but not listed here.
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2 authors.
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Abstract
Individuals exhibit considerable and unpredictable variability in painful percepts in response to the same nociceptive stimulus. Previous work has found neural responses that, while not necessarily responsible for the painful percepts themselves, can still correlate well with intensity of pain perception within a given individual. However, there is no reliable neural response reflecting the variability in pain perception across individuals. Here, we use an electrophysiological approach in humans and rodents to demonstrate that brain oscillations in the gamma band [gamma-band event-related synchronization (γ-ERS)] sampled by central electrodes reliably predict pain sensitivity across individuals. We observed a clear dissociation between the large number of neural measures that reflected subjective pain ratings at within-subject level but not across individuals, and γ-ERS, which reliably distinguished subjective ratings within the same individual but also coded pain sensitivity across different individuals. Importantly, the ability of γ-ERS to track pain sensitivity across individuals was selective because it did not track the between-subject reported intensity of nonpainful but equally salient auditory, visual, and nonnociceptive somatosensory stimuli. These results also demonstrate that graded neural activity related to within-subject variability should be minimized to accurately investigate the relationship between nociceptive-evoked neural activities and pain sensitivity across individuals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.