Evidence map›Paper›PMID 30642948›Full record

ArticleMolecular and cellular biology2019

Germ Line Deletion Reveals a Nonessential Role of Atypical Mitogen-Activated Protein Kinase 6/Extracellular Signal-Regulated Kinase 3.

N Ronkina, K Schuster-Gossler, F Hansmann, H Kunze-Schumacher, I Sandrock, T Yakovleva, J Lafera, W Baumgärtner, A Krueger, I Prinz and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular and cellular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Atypical MAPKs in cancer.The FEBS journal · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

N RonkinaInstitute of Cell Biochemistry, Hannover Medical School, Hannover, Germany.
K Schuster-GosslerInstitute of Molecular Biology, Hannover Medical School, Hannover, Germany.
F HansmannUniversity of Veterinary Medicine Hannover, Department of Pathology, Hannover, Germany.
H Kunze-SchumacherInstitute of Molecular Medicine, Goethe University Frankfurt am Main, Frankfurt am Main, Germany.
I SandrockInstitute of Immunology, Hannover Medical School, Hannover, Germany.
T YakovlevaInstitute of Cell Biochemistry, Hannover Medical School, Hannover, Germany.
J LaferaInstitute of Cell Biochemistry, Hannover Medical School, Hannover, Germany.
W BaumgärtnerUniversity of Veterinary Medicine Hannover, Department of Pathology, Hannover, Germany.
A KruegerInstitute of Molecular Medicine, Goethe University Frankfurt am Main, Frankfurt am Main, Germany.
I PrinzInstitute of Immunology, Hannover Medical School, Hannover, Germany.
A GosslerInstitute of Molecular Biology, Hannover Medical School, Hannover, Germany.
A Kotlyarov *Institute of Cell Biochemistry, Hannover Medical School, Hannover, Germany.
M Gaestel *Institute of Cell Biochemistry, Hannover Medical School, Hannover, Germany gaestel.matthias@mh-hannover.de.
Medizinische Hochschule Hannover · DEGoethe University Frankfurt · DEInstitute of Molecular Biology · DEUniversity of Veterinary Medicine Hannover, Foundation · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitogen-activated protein kinase 6/extracellular signal-regulated kinase 3 (MAPK6/ERK3) is an atypical member of the MAPKs. An essential role has been suggested by the perinatal lethal phenotype of ERK3 knockout mice carrying a

Indexed as

Germ-Line MutationAnimalsFemaleGene DeletionGerm CellsIntracellular Signaling Peptides and ProteinsMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein Kinase 6Protein BindingProtein Serine-Threonine KinasesSequence DeletionSignal TransductionT-LymphocytesZona PellucidaIntracellular Signaling Peptides and ProteinsMapk6 protein, mouseMAP-kinase-activated kinase 5Mitogen-Activated Protein Kinase 6Protein Serine-Threonine Kinasesgene deletionMAPKAPK5/MK5mitogen-activated protein kinasesprotein kinase

Identifiers

PMID30642948
PMCPMC6399663
OpenAlexW2918171554

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.