Evidence map›Paper›PMID 30642934›Full record

ArticleAntimicrobial agents and chemotherapy2019

Small-Molecule Inhibitor of FosA Expands Fosfomycin Activity to Multidrug-Resistant Gram-Negative Pathogens.

Adam D Tomich, Erik H Klontz, Daniel Deredge, John P Barnard, Christi L McElheny, Megan L Eshbach, Ora A Weisz, Patrick Wintrode, Yohei Doi, Eric J Sundberg and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Comprehensive Genomic Analysis ofMicroorganisms · 2025
    Article
  4. Review
  5. Article
  6. Potential Inhibitors TargetingIndian journal of microbiology · 2022
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Potential of 2-Chloro-Molecules (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Adam D Tomich *Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Erik H Klontz *Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Daniel DeredgeDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland, USA.
John P BarnardDivision of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Christi L McElhenyDivision of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Megan L EshbachDivision of Renal-Electrolyte, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Ora A WeiszDivision of Renal-Electrolyte, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Patrick WintrodeDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland, USA.
Yohei DoiDivision of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Eric J SundbergInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA ESundberg@ihv.umaryland.edu nps2@pitt.edu.
Nicolas Sluis-CremerDivision of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA ESundberg@ihv.umaryland.edu nps2@pitt.edu.
University of Pittsburgh · USUniversity of Maryland, Baltimore · US

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACKSON, EDWIN KERRY · 2008 to 2022
$13.4M
NRSA Training CoreTL1TR001858 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RADOMSKI, THOMAS, RUBIO, DORIS M · 2016 to 2025
$11.1M
Signaling Pathways in Innate ImmunityT32AI095190 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Stefanie N. Vogel · 2012 to 2026
$4.7M
Renal and Epithelial Biology Training ProgramT32DK061296 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2002 to 2022
$3.1M
Mechanisms and implications of fosfomycin resistance in Escherichia coliR21AI123747 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOI, YOHEI · 2016 to 2017
$417k
NCATS NIH HHS TL1 TR001858NIAID NIH HHS R21 AI123747NIAID NIH HHS T32 AI095190NIDDK NIH HHS P30 DK079307NIDDK NIH HHS T32 DK061296
6 · The paper itself

Abstract

The spread of multidrug or extensively drug-resistant Gram-negative bacteria is a serious public health issue. There are too few new antibiotics in development to combat the threat of multidrug-resistant infections, and consequently the rate of increasing antibiotic resistance is outpacing the drug development process. This fundamentally threatens our ability to treat common infectious diseases. Fosfomycin (FOM) has an established track record of safety in humans and is highly active against

Indexed as

Anti-Bacterial AgentsDrug Resistance, BacterialDrug Resistance, Multiple, BacterialEscherichia coliEscherichia coli ProteinsFosfomycinHumansKlebsiella pneumoniaeMicrobial Sensitivity TestsPseudomonas aeruginosaPyrazolesPyrimidinesAnti-Bacterial AgentsEscherichia coli ProteinsFosA(3) protein, E coliFosfomycinPyrazolesPyrimidinesFosAfosfomycinGram negative

Identifiers

PMID30642934
PMCPMC6395921
OpenAlexW2911047292

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.