Evidence map›Paper›PMID 30642932›Full record

ArticleAntimicrobial agents and chemotherapy2019

Vacuolar Sequestration of Azoles, a Novel Strategy of Azole Antifungal Resistance Conserved across Pathogenic and Nonpathogenic Yeast.

Nitesh Kumar Khandelwal, Mohd Wasi, Remya Nair, Meghna Gupta, Mohit Kumar, Alok K Mondal, Naseem A Gaur, Rajendra Prasad

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. The Vacuolar Protein 8 (Vac8) Homolog inJournal of fungi (Basel, Switzerland) · 2025
    Article
  4. Combining Fluconazole with Benzo[Molecules (Basel, Switzerland) · 2024
    Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Molecular investigations onRSC advances · 2022
    Article
  13. Article
  14. Antibiotics (Basel, Switzerland) · 2020
    Review
  15. Article
  16. Role of lipid transporters in fungal physiology and pathogenicity.Computational and structural biotechnology journal · 2019
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nitesh Kumar KhandelwalSchool of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Mohd Wasi *School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Remya Nair *School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Meghna GuptaSchool of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Mohit KumarInternational Centre for Genetic Engineering and Biotechnology, New Delhi, India.
Alok K MondalSchool of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Naseem A GaurInternational Centre for Genetic Engineering and Biotechnology, New Delhi, India.
Rajendra PrasadAmity Institute of Biotechnology and Integrative Sciences and Health, Amity University Haryana, Gurgaon, India rprasad@ggn.amity.edu.
Jawaharlal Nehru University · INInternational Centre for Genetic Engineering and Biotechnology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Target alteration and overproduction and drug efflux through overexpression of multidrug transporters localized in the plasma membrane represent the conventional mechanisms of azole antifungal resistance. Here, we identify a novel conserved mechanism of azole resistance not only in the budding yeast

Indexed as

Amino Acid SubstitutionAntifungal AgentsATP-Binding Cassette TransportersAzolesCandida albicansDrug Resistance, FungalMembrane ProteinsMolecular ChaperonesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAntifungal AgentsATP-Binding Cassette TransportersAzolesMembrane ProteinsMolecular ChaperonesSaccharomyces cerevisiae ProteinsYBT1 protein, S cerevisiaeABC transporterazoleCandida albicansdrug resistanceSaccharomyces cerevisiae

Identifiers

PMID30642932
PMCPMC6395933
OpenAlexW2910843437

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.