ArticleBlood2019
A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology.
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Article in Blood, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
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34citing papers in PubMed, 3 pooled it
2.4field-weighted citation impact, top 11% of its field
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Appraising the Causal Role of Risk Factors in Coronary Artery Disease and Stroke: A Systematic Review of Mendelian Randomization Studies.Journal of the American Heart Association · 2023Pooled it
- The effects of coagulation factors on the risk of endometriosis: a Mendelian randomization study.BMC medicine · 2023Pooled it
- A Genome-Wide Association Study of Prediabetes Status Change.Frontiers in endocrinology · 2022Pooled it
- Trial
- Identification of Plasma Protein Biomarkers for Early-Onset Stroke through Mendelian Randomization.medRxiv : the preprint server for health sciences · 2026Article
- Leveraging Mendelian randomization to inform drug discovery and development for ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Historical review: more than two decades understanding the genetic architecture of hemostasis and thrombosis.Journal of thrombosis and haemostasis : JTH · 2026Review
- Association Between Hemostatic Profiles and Hypertensive Disorders of Pregnancy: A Multi-Omics Mendelian Randomization Study.International journal of women's health · 2026Article
- Multipopulation GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafish.Blood advances · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Integrative machine learning and Mendelian randomization identify causal laboratory biomarkers for coronary artery lesions in Kawasaki disease: a prospective study.Frontiers in genetics · 2025Article
- [Exploring the Causal Relationship Between Coagulation Function and Gestational Diabetes Mellitus Through Mendelian Randomization].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
- A multitrait genetic study of hemostatic factors and hemorrhagic transformation after stroke treatment.Journal of thrombosis and haemostasis : JTH · 2024Article
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- Novel functional atrial fibrillation risk genes and pathways identified from coexpression analyses in human left atria.Heart rhythm · 2023Article
- Hacking hematopoiesis - emerging tools for examining variant effects.Disease models & mechanisms · 2023Article
- Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association.Circulation · 2023Review
- CYP4 subfamily V member 2 (CYP4V2) polymorphisms were associated with ischemic stroke in Chinese Han population.BMC medical genomics · 2022Article
- Article
- Whole-exome sequencing of 14 389 individuals from the ESP and CHARGE consortia identifies novel rare variation associated with hemostatic factors.Human molecular genetics · 2022Article
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Authors and funding
47 authors at 20 institutions in 9 countries.
Paul S de VriesHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.
Maria Sabater-LlealUnit of Genomics of Complex Diseases, Institut d'Investigació Biomèdica Sant Pau (IIB-Sant Pau), Barcelona, Spain.ORCID 0000-0002-0128-379X
Jennifer E HuffmanPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA.
Jonathan MartenMedical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
Ci SongPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA.
Nathan PankratzDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota, Minneapolis, MN.
Traci M BartzDepartment of Biostatistics, University of Washington, Seattle, WA.
Hugoline G de HaanDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Graciela E DelgadoVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
John D EicherPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA.
Angel Martinez-PerezUnit of Genomics of Complex Diseases, Institut d'Investigació Biomèdica Sant Pau (IIB-Sant Pau), Barcelona, Spain.ORCID 0000-0002-5934-1454
Cavin K Ward-CavinessNational Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Chapel Hill, NC.
Jennifer A BrodyDepartment of Medicine, University of Washington, Seattle, WA.
Ming-Huei ChenPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA.
Moniek P M de MaatDepartment of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Mattias FrånbergCardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Dipender GillDepartment of Epidemiology and Biostatistics and.
Marcus E KleberVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Fernando RivadeneiraDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
José Manuel SoriaUnit of Genomics of Complex Diseases, Institut d'Investigació Biomèdica Sant Pau (IIB-Sant Pau), Barcelona, Spain.
Weihong TangDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.
Geoffrey H ToflerRoyal North Shore Hospital, University of Sydney, Sydney, Australia.
André G UitterlindenDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Astrid van Hylckama VliegDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Sudha SeshadriThe Framingham Heart Study, Framingham, MA.
Eric BoerwinkleHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.
Neil M DaviesMRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Anne-Katrin GieseDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
M Kamran IkramDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Steven J KittnerDepartment of Neurology, School of Medicine, University of Maryland, Baltimore, MD.
Barbara McKnightDepartment of Biostatistics, University of Washington, Seattle, WA.
Bruce M PsatyDepartment of Medicine.
Alex P ReinerFred Hutchinson Cancer Research Center, Seattle, WA.
Muralidharan SargurupremrajINSERM U1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA.ORCID 0000-0002-2756-4370
INVENT Consortium
MEGASTROKE Consortium of the International Stroke Genetics Consortium
Myriam FornageHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.
Anders HamstenCardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Winfried MärzVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Frits R RosendaalDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Juan Carlos SoutoUnitat d'Hemostasia i Trombosi, Hospital de la Sant Creu i Sant Pau, Barcelona, Spain.
Abbas DehghanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Andrew D JohnsonPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA.
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.
Christopher J O'DonnellPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA.
Nicholas L SmithKaiser Permanente Washington Research Institute, Kaiser Permanente Washington, Seattle, WA.
Erasmus MC · NLNational Institutes of Health · USUniversity of Washington · USHospital de Sant Pau · ESKarolinska University Hospital · SELeiden University Medical Center · NLHeidelberg University · DEKaiser Permanente Washington Health Research Institute · USUniversity of Minnesota · USBaylor University · USBoston University · USBrown Foundation · USEnvironmental Protection Agency · USHarvard University · USImperial College London · GBMedical University of Graz · ATThe Lundquist Institute · USThe University of Sydney · AUThe University of Texas Health Science Center at Houston · USUniversité de Bordeaux · FR
Funding
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4MUC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3MBuilding on GWAS for NHLBI-disease: the CHARGE consortiumRC2HL102419 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2009 to 2010
$27.6MCardiovascular Genomics and Bioinformatics projectsZIAHL006170 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI JOHNSON, ANDREW · 2013 to 2025
$25.3MPRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9MA Center for GEI Association StudiesU01HG004424 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2010
$21.4MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MTemporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3MEpidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8MExceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5MARRA NIH HHS 5RC2HL102419Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_12013/1Medical Research Council MC_UU_12013/9NCATS NIH HHS UL1 TR000124NCRR NIH HHS UL1 RR025005NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01 HG004424NHGRI NIH HHS U01 HG004446NHGRI NIH HHS U01 HG004729NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268200900041CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201300025CNHLBI NIH HHS HHSN268201300027CNHLBI NIH HHS HHSN268201300028CNHLBI NIH HHS HHSN268201300029CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC065226NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL085251NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL134894NHLBI NIH HHS RC2 HL102419NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS P30 AG010129NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG054076NIA NIH HHS U01 AG049505NIA NIH HHS U01 AG052409NIDDK NIH HHS P30 DK063491NINDS NIH HHS R01 NS017950NINDS NIH HHS R01 NS105150NINDS NIH HHS UH3 NS100605Wellcome Trust
Abstract
Factor VII (FVII) is an important component of the coagulation cascade. Few genetic loci regulating FVII activity and/or levels have been discovered to date. We conducted a meta-analysis of 9 genome-wide association studies of plasma FVII levels (7 FVII activity and 2 FVII antigen) among 27 495 participants of European and African ancestry. Each study performed ancestry-specific association analyses. Inverse variance weighted meta-analysis was performed within each ancestry group and then combined for a
Indexed as
Genome-Wide Association StudyPolymorphism, Single NucleotideBrain IschemiaCohort StudiesCo-Repressor ProteinsCoronary Artery DiseaseDNA-Binding ProteinsFactor VIIFemaleFollow-Up StudiesGenetic LociGenetic Predisposition to DiseaseHumansMaleMembrane Transport ProteinsMendelian Randomization AnalysisCo-Repressor ProteinsDNA-Binding ProteinsFactor VIIJAZF1 protein, humanMembrane Transport ProteinsNeoplasm ProteinsREEP3 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.