Evidence map›Paper›PMID 30642906›Full record

ArticleInfection and immunity2019

Human Intestinal Enteroids as a Model System of

Benjamin J Koestler, Cara M Ward, C R Fisher, Anubama Rajan, Anthony W Maresso, Shelley M Payne

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 75 citations in OpenAlex.

  1. Article
  2. Sequential invasion of epithelial and immune cells in Shigellosis.bioRxiv : the preprint server for biology · 2026
    Article
  3. bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Healthcare (Basel, Switzerland) · 2025
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Epithelial Cell Infection Analyses with Shigella.Journal of visualized experiments : JoVE · 2024
    Article
  16. In Vitro Models for Investigating Intestinal Host-Pathogen Interactions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  17. Shigella-Controlled Human Infection Models: Current and Future Perspectives.Current topics in microbiology and immunology · 2024
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Benjamin J KoestlerDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA bkoestler@austin.utexas.edu.ORCID 0000-0001-7213-0953
Cara M WardDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA.
C R FisherDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA.
Anubama RajanDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.
Anthony W MaressoDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.
Shelley M PayneDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA.
The University of Texas at Austin · USBaylor College of Medicine · US

Funding

Viral Diversity and Pathogenicity in Mucosal Respiratory and Gastrointestinal DiseaseU19AI144297 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI MARESSO, ANTHONY W · 2019 to 2024
$30.1M
Novel Platforms for Human Intestinal Enteroids: Matrix, Mechanics, and TopographyU19AI116497 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI GRANDE-ALLEN, KATHRYN JANE · 2015 to 2025
$13.2M
ROLE OF CARBON METABOLISM AND VIRULENCE OF SHIGELLA FLEXNERIR37AI016935 · NIAID · UNIVERSITY OF TEXAS AUSTIN · PI Shelley M. Payne · 2003 to 2026
$6.0M
Role of carbon metabolism in virulence of Shigella flexneriR01AI016935 · NIAID · UNIVERSITY OF TEXAS AUSTIN · PI PAYNE, SHELLEY M. · 1985 to 2017
$2.6M
A colonoid model for Shigella flexneri pathogenesisR21AI131497 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI MARESSO, ANTHONY W, PAYNE, SHELLEY M. · 2017 to 2018
$447k
Branched Chain Amino Acid Metabolism During AnthraxR21AI146481 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI MARESSO, ANTHONY W · 2019 to 2020
$440k
NIAID NIH HHS R21 AI131497NIAID NIH HHS R21 AI146481NIAID NIH HHS R37 AI016935NIAID NIH HHS U19 AI116497NIAID NIH HHS U19 AI144297
6 · The paper itself

Abstract

The enteric bacterium and intracellular human pathogen

Indexed as

Models, BiologicalCell Culture TechniquesDysentery, BacillaryHumansIntestinal MucosaLarge Neutral Amino Acid-Transporter 1OrganoidsShigella flexneriStem CellsVirulenceLarge Neutral Amino Acid-Transporter 1host-pathogen interactionshuman intestinal enteroidintracellular pathogenShigella flexneri

Identifiers

PMID30642906
PMCPMC6434139
OpenAlexW2909033323

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.