Evidence map›Paper›PMID 30642902›Full record

ArticleInfection and immunity2019

Immunological Responses to the Relapsing Fever Spirochete

Monica E Embers, Aparna Krishnavajhala, Brittany A Armstrong, Michael W Curtis, Bapi Pahar, Hannah K Wilder, Michael S Allen, Paul A Beare, Nicole R Hasenkampf, Job E Lopez

Abstract read
In one paragraph

Article in Infection and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Monica E EmbersDivision of Immunology, Tulane National Primate Research Center, Tulane University Health Sciences, Covington, Louisiana, USA members@tulane.edu.
Aparna KrishnavajhalaDepartment of Pediatrics, National School of Tropical Medicine, Houston, Texas, USA.
Brittany A ArmstrongDepartment of Pediatrics, National School of Tropical Medicine, Houston, Texas, USA.
Michael W CurtisDepartment of Pediatrics, National School of Tropical Medicine, Houston, Texas, USA.
Bapi PaharDivision of Comparative Pathology, Tulane National Primate Research Center, Tulane University Health Sciences, Covington, Louisiana, USA.
Hannah K WilderDepartment of Pediatrics, National School of Tropical Medicine, Houston, Texas, USA.
Michael S AllenDepartment of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, Fort Worth, Texas, USA.ORCID 0000-0003-2293-8078
Paul A BeareLaboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Nicole R HasenkampfDivision of Immunology, Tulane National Primate Research Center, Tulane University Health Sciences, Covington, Louisiana, USA.
Job E LopezDepartment of Pediatrics, National School of Tropical Medicine, Houston, Texas, USA.

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
Relapsing Fever Spirochete Protein Production within the VectorR21AI103724 · NIAID · MISSISSIPPI STATE UNIVERSITY · PI LOPEZ, JOB E · 2013 to 2014
$363k
Identifying Borrelia turicatae genes needed for colonization and transmission froK22AI091652 · NIAID · MISSISSIPPI STATE UNIVERSITY · PI LOPEZ, JOB E · 2012 to 2013
$270k
NIAID NIH HHS K22 AI091652NIAID NIH HHS R21 AI103724NIH HHS P51 OD011104
6 · The paper itself

Abstract

The global public health impact of relapsing fever (RF) spirochetosis is significant, since the pathogens exist on five of seven continents. The hallmark sign of infection is episodic fever and the greatest threat is to the unborn. With the goal of better understanding the specificity of B-cell responses and the role of immune responses in pathogenicity, we infected rhesus macaques with

Indexed as

AnimalsAntibodies, BacterialAntibody FormationBacterial Outer Membrane ProteinsBorreliaDisease Models, AnimalHumansInterleukin-1betaMacaca mulattaMaleMiceMice, Inbred ICRRelapsing FeverTicksTumor Necrosis Factor-alphaVirulenceAntibodies, BacterialBacterial Outer Membrane ProteinsBipA protein, BordetellaInterleukin-1betaTumor Necrosis Factor-alphaadaptive immunityBorreliahumoral immunitynonhuman primaterelapsing fever

Identifiers

PMID30642902
PMCPMC6434134

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.