Evidence map›Paper›PMID 30642900›Full record

ArticleInfection and immunity2019

Evaluating Shigella flexneri Pathogenesis in the Human Enteroid Model.

Sridevi Ranganathan, Michele Doucet, Christen L Grassel, BreOnna Delaine-Elias, Nicholas C Zachos, Eileen M Barry

Open access · hybridAbstract read
In one paragraph

Article in Infection and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 105 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. A RecombinantInternational journal of molecular sciences · 2024
    Article
  11. Intestinal organ chips for disease modelling and personalized medicine.Nature reviews. Gastroenterology & hepatology · 2024
    Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Epithelial Cell Infection Analyses with Shigella.Journal of visualized experiments : JoVE · 2024
    Article
  18. Article
  19. Shigella-Controlled Human Infection Models: Current and Future Perspectives.Current topics in microbiology and immunology · 2024
    Review
  20. Differential role of M cells in enteroid infection byFrontiers in cellular and infection microbiology · 2024
    Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sridevi RanganathanCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Michele DoucetDepartment of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Christen L GrasselCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
BreOnna Delaine-EliasCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Nicholas C ZachosDepartment of Medicine, Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Eileen M BarryCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA embarry@som.umaryland.edu.
University of Maryland, Baltimore · USJohns Hopkins Medicine · USJohns Hopkins University · US

Funding

Shigella Live Vector-Based Multivalent VaccineU19AI109776 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LEVINE, MYRON MAX · 2014 to 2018
$25.4M
Project 3 - Human colonoids as a model for the pathobiology of EHECP01AI125181 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI RUIZ, FERNANDO · 2016 to 2025
$18.6M
Translational Research Enhancement CoreP30DK089502 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI ZACHOS, NICHOLAS CONSTANTINE · 2011 to 2020
$12.0M
NIAID NIH HHS P01 AI125181NIAID NIH HHS U19 AI109776NIDDK NIH HHS P30 DK089502
6 · The paper itself

Abstract

The enteric pathogen

Indexed as

Cells, CulturedDysentery, BacillaryHumansIntestinesModels, BiologicalOrganoidsReceptors, G-Protein-CoupledShigella flexneriStem CellsVirulenceLGR5 protein, humanReceptors, G-Protein-Coupledcolonoidhuman intestinal enteroidsM cellsS. flexneri pathogenesis

Identifiers

PMID30642900
PMCPMC6434113
OpenAlexW2910770721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.