ArticleNeuroImage. Clinical2019
Sensory-motor network functional connectivity in children with unilateral cerebral palsy secondary to perinatal stroke.
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Effects of computerized cognitive training on functional brain networks in patients with vascular cognitive impairment and no dementia.CNS neuroscience & therapeutics · 2024Trial
- Exploring communication impairments in children with spastic cerebral palsy through neurovascular coupling: a cross-sectional study.Quantitative imaging in medicine and surgery · 2025Article
- Functional Connectivity of Hippocampal Circuits and Visual Memory Function in Children and Adolescents With Perinatal Stroke.Human brain mapping · 2025Article
- Assessment of cortical activity, functional connectivity, and neuroplasticity in cerebral palsy using functional near-infrared spectroscopy: A scoping review.Developmental medicine and child neurology · 2025Article
- Brain functional connectivity and activity during motor control in children with cerebral palsy: a pilot cross-sectional fNIRS study.Translational pediatrics · 2025Article
- Dynamic Task-Related Changes in Electroencephalography Brain Connectivity During a Button-Press Task in Children with and Without Bilateral Cerebral Palsy.Brain connectivity · 2025Article
- Executive functioning, ADHD symptoms and resting state functional connectivity in children with perinatal stroke.Brain imaging and behavior · 2024Article
- Structural covariance alterations reveal motor damage in periventricular leukomalacia.Brain communications · 2024Article
- Electroencephalography-Derived Functional Connectivity in Sensorimotor Networks in Post Stroke Fatigue.Brain topography · 2023Article
- Corticomuscular Coherence in Children with Unilateral Cerebral Palsy: A Feasibility and Preliminary Protocol Study.Journal of child neurology · 2023Article
- Neuro-imaging characteristics of sensory impairment in cerebral palsy; a systematic review.Frontiers in rehabilitation sciences · 2023Review
- Structural connectivity of the sensorimotor network within the non-lesioned hemisphere of children with perinatal stroke.Scientific reports · 2022Article
- Ipsilesional volume loss of basal ganglia and thalamus is associated with poor hand function after ischemic perinatal stroke.BMC neurology · 2022Article
- Somatosensory deficits and neural correlates in cerebral palsy: a scoping review.Developmental medicine and child neurology · 2021Article
- Perinatal stroke: mapping and modulating developmental plasticity.Nature reviews. Neurology · 2021Review
- A connectome-based approach to assess motor outcome after neonatal arterial ischemic stroke.Annals of clinical and translational neurology · 2021Article
- Mu Rhythm during Standing and Walking Is Altered in Children with Unilateral Cerebral Palsy Compared to Children with Typical Development.Developmental neurorehabilitation · 2021Article
- Developmental neuroplasticity of the white matter connectome in children with perinatal stroke.Neurology · 2020Article
- Tools and Techniques Used With Robotic Devices to Quantify Upper-Limb Function in Typically Developing Children: A Systematic Review.Rehabilitation process and outcome · 2020Review
- Structural and functional connectivity of motor circuits after perinatal stroke: A machine learning study.NeuroImage. Clinical · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPerinatal stroke is the most common cause of unilateral cerebral palsy. Mechanisms of post-stroke developmental plasticity in children are poorly understood. To better understand the relationship between functional connectivity and disability, we used resting-state fMRI to compare sensorimotor connectivity with clinical dysfunction.
methodsSchool-aged children with periventricular venous infarction (PVI) and unilateral cerebral palsy were compared to controls. Resting-state BOLD signal was acquired on 3 T MRI and analyzed using CONN in SPM12. Functional connectivity was computed between S1, M1, supplementary motor area (SMA), and thalamus of the left/non-lesioned and right/lesioned hemisphere. Primary outcome was connectivity expressed as a Fisher-transformed correlation coefficient. Motor function was measured using the Assisting Hand Assessment (AHA), and Melbourne Assessment (MA). Proprioceptive function was measured using a robotic position matching task (VarXY).
resultsParticipants included 15 PVI and 21 controls. AHA and MA in stroke patients were negatively correlated with connectivity (increased connectivity = poorer performance). Position sense was inversely correlated with connectivity (increased connectivity = improved performance) between the non-lesioned S1 and thalamus/SMA. In controls, VarXY was positively correlated with connectivity between the thalamus and bilateral sensorimotor regions.
conclusionsResting state fMRI measures of sensorimotor connectivity are associated with clinical sensorimotor function in children with unilateral cerebral palsy secondary to PVI. Greater insight into understanding reorganization of brain networks following perinatal stroke may facilitate personalized rehabilitation.
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