Evidence map›Paper›PMID 30642366›Full record

ArticleBMC research notes2019

Periodic mild heat stimuli diminish extracellular matrix synthesis in pellet cultured human chondrocytes.

Akira Ito, Tomoki Aoyama, Hirotaka Iijima, Kohei Nishitani, Junichi Tajino, Hiroshi Kuroki

Open access · goldAbstract read
In one paragraph

Article in BMC research notes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Mimicking Loading-Induced Cartilage Self-HeatingACS biomaterials science & engineering · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Akira ItoDepartment of Motor Function Analysis, Human Health Sciences, Graduate School of Medicine, Kyoto University, 53 Kawahara-cho, Sakyo-ku, Shogoin, Kyoto, 606-8507, Japan.ORCID http://orcid.org/0000-0002-9645-9777
Tomoki AoyamaDepartment of Development and Rehabilitation of Motor Function, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.
Hirotaka IijimaDepartment of Motor Function Analysis, Human Health Sciences, Graduate School of Medicine, Kyoto University, 53 Kawahara-cho, Sakyo-ku, Shogoin, Kyoto, 606-8507, Japan.
Kohei NishitaniDepartment of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan.
Junichi TajinoDepartment of Development and Rehabilitation of Motor Function, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.
Hiroshi KurokiDepartment of Motor Function Analysis, Human Health Sciences, Graduate School of Medicine, Kyoto University, 53 Kawahara-cho, Sakyo-ku, Shogoin, Kyoto, 606-8507, Japan. kuroki.hiroshi.6s@kyoto-u.ac.jp.
Kyoto University · JPKeio University · JP

Funding

Japan Society for the Promotion of Science 15J06180Japan Society for the Promotion of Science 25242055
6 · The paper itself

Abstract

objectiveThis study aimed to clarify the effects of periodic mild heat stimuli on extracellular matrix (ECM) synthesis of adult human chondrocytes in 3-dimensional pellet culture.

resultsHuman articular chondrocytes were subjected to pellet culture at 37 °C for 3 days. Thereafter, the pellets were divided into three groups: 32 °C group which was cultured at 32 °C without heat stimuli, 32 °C + Heat group which was cultured at 32 °C and applied periodic heat stimuli, 37 °C group which was cultured at 37 °C. Heat stimuli were given by transferring the pellets into a CO

Indexed as

Hot TemperatureAggrecansCells, CulturedChondrocytesCollagen Type ICollagen Type I, alpha 1 ChainCollagen Type IIExtracellular MatrixHumansACAN protein, humanAggrecansCOL2A1 protein, humanCollagen Type ICollagen Type I, alpha 1 ChainCollagen Type IIChondrocytesCollagenExtracellular matrixHeat stimuliPellet cultureTemperature

Identifiers

PMID30642366
PMCPMC6332905
OpenAlexW2912575567

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.