Evidence map›Paper›PMID 30642363›Full record

ArticleBreast cancer research : BCR2019

Identification of novel common breast cancer risk variants at the 6q25 locus among Latinas.

Joshua Hoffman, Laura Fejerman, Donglei Hu, Scott Huntsman, Min Li, Esther M John, Gabriela Torres-Mejia, Larry Kushi, Yuan Chun Ding, Jeffrey Weitzel and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research : BCR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Evaluation of Multiple Breast Cancer Polygenic Risk Score Panels in Women of Latin American Heritage.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
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  7. Review
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  9. Association ofmedRxiv : the preprint server for health sciences · 2023
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  10. Review
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  12. Article
  13. Association between Ancestry-Specific 6q25 Variants and Breast Cancer Subtypes in Peruvian Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022
    Article
  14. Review
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  19. A review of linc00673 as a novel lncRNA for tumor regulation.International journal of medical sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 12 institutions in 4 countries.

Joshua HoffmanDepartment of Epidemiology and Biostatistics, Institute of Human Genetics, University of California, San Francisco, San Francisco, CA, USA.
Laura FejermanDivision of General Internal Medicine, Department of Medicine, Institute of Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, Box 0320, San Francisco, CA, 94143, USA.
Donglei HuDivision of General Internal Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Scott HuntsmanDivision of General Internal Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Min LiDivision of General Internal Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Esther M JohnDepartment of Medicine, Stanford University, Stanford, CA, USA.
Gabriela Torres-MejiaNational Institute of Public Health, Cuernavaca, Mexico.
Larry KushiDivision of Research, Kaiser Permanente, Oakland, Northern California, USA.
Yuan Chun DingBeckman Research Institute of City of Hope, Department of Population Sciences, City of Hope, Duarte, CA, USA.
Jeffrey WeitzelCity of Hope National Medical Center, Clinical Cancer Genetics, Duarte, CA, USA.
Susan L NeuhausenBeckman Research Institute of City of Hope, Department of Population Sciences, City of Hope, Duarte, CA, USA.
Paul LottDepartment of Biochemistry and Molecular Medicine, University of California, Davis, Davis, CA, USA.
COLUMBUS Consortium
Magdalena EcheverryUniversity of Tolima, Ibague, Colombia.
Luis Carvajal-CarmonaDepartment of Biochemistry and Molecular Medicine, University of California, Davis, Davis, CA, USA.
Esteban BurchardDepartment of Biophamaceutical Sciences, Lung Biology Center, University of California, San Francisco, San Francisco, CA, USA.
Celeste EngDepartment of Biophamaceutical Sciences, Lung Biology Center, University of California, San Francisco, San Francisco, CA, USA.
Jirong LongDepartment of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Wei ZhengDepartment of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Olufunmilayo OlopadeDepartment of Public Health Sciences, University of Chicago School of Medicine, Chicago, IL, USA.
Dezheng HuoDepartment of Medicine, Section of Oncology, University of Chicago School of Medicine, Chicago, IL, USA.
Christopher HaimanDepartment of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Elad ZivDivision of General Internal Medicine, Department of Medicine, Institute of Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, Box 0320, San Francisco, CA, 94143, USA. Elad.Ziv@ucsf.edu.ORCID 0000-0002-2324-2884
University of California, San Francisco · USCity of Hope · USUniversity of California, Davis · USVanderbilt University Medical Center · USChicago Department of Public Health · USCity Of Hope National Medical Center · USInstituto Nacional de Salud Pública · MXKaiser Permanente · USStanford University · USUniversity of Chicago · USUniversity of Southern California · USUniversity of Tolima · CO

Funding

GENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSR01CA063464 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2001 to 2005
$23.2M
Multiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2M
Breast Cancer Family Registry CohortUM1CA164920 · NCI · CANCER PREVENTION INSTIT OF CALIFORNIA · PI ANDRULIS, IRENE, BUYS, SAUNDRA S · 2012 to 2017
$12.7M
Understanding Ethnic Differences in Cancer: The Multiethnic Cohort StudyUM1CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HENDERSON, BRIAN E, LE MARCHAND, LOIC · 2012 to 2014
$11.3M
The Airway Functional Genomics of Bronchodilator Drug Response in Minority Children with AsthmaR01HL117004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, SEIBOLD, MAX A · 2013 to 2022
$9.3M
Training in Molecular& Genetic Epidemiology of CancerR25CA112355 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WITTE, JOHN S. · 2005 to 2018
$6.5M
Social Interventions to address disparities In young adult tobacco useP60MD006902 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2012 to 2016
$6.4M
Shanghai Womens Health StudyUM1CA182910 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2014 to 2018
$5.9M
Gene-environments and Admixture in Latino Asthmatics (GALA 2)R01ES015794 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$5.4M
SF BUILD: Enabling Students to Represent in ScienceRL5GM118984 · NIGMS · SAN FRANCISCO STATE UNIVERSITY · PI MARQUEZ-MAGANA, LETICIA MARIA, MORRIS, MEGHAN D · 2015 to 2023
$5.2M
Germline and Tumor Genomic Analyses of Breast Cancer in LatinasR01CA184585 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NEUHAUSEN, SUSAN L., ZIV, ELAD · 2014 to 2018
$4.2M
Transcriptomic and Pharmacogenetic Asthma Endotypes in Minority ChildrenR01HL135156 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A, ZIV, ELAD · 2017 to 2021
$4.1M
NCI NIH HHS 5UM1CA164973NCI NIH HHS CA142996NCI NIH HHS CA161032NCI NIH HHS CA63446NCI NIH HHS CA77305NCI NIH HHS K24 CA169004NCI NIH HHS K24CA169004NCI NIH HHS R01 CA063446NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA120120NCI NIH HHS R01CA120120NCI NIH HHS R01 CA132839NCI NIH HHS R01 CA142996NCI NIH HHS R01 CA148667NCI NIH HHS R01CA148667NCI NIH HHS R01CA184545NCI NIH HHS R01 CA184585NCI NIH HHS R01 CA63464NCI NIH HHS R25 CA112355NCI NIH HHS R25CA112355NCI NIH HHS R37 CA054281NCI NIH HHS R37 CA54281NCI NIH HHS U01 CA161032NCI NIH HHS UM1 CA164920NCI NIH HHS UM1 CA164973NCI NIH HHS UM1 CA182910NHLBI NIH HHS R01 HL117004NHLBI NIH HHS R01 HL135156NIEHS NIH HHS R01 ES015794NIEHS NIH HHS R21 ES024844NIGMS NIH HHS RL5 GM118984NIMHD NIH HHS P60 MD006902NIMHD NIH HHS R01 MD010443
6 · The paper itself

Abstract

backgroundBreast cancer is a partially heritable trait and genome-wide association studies (GWAS) have identified over 180 common genetic variants associated with breast cancer. We have previously performed breast cancer GWAS in Latinas and identified a strongly protective single nucleotide polymorphism (SNP) at 6q25, with the protective minor allele originating from indigenous American ancestry. Here we report on fine mapping of the 6q25 locus in an expanded sample of Latinas.

methodsWe performed GWAS in 2385 cases and 6416 controls who were either US Latinas or Mexican women. We replicated the top SNPs in 2412 cases and 1620 controls of US Latina, Mexican, and Colombian women. In addition, we validated the top novel variants in studies of African, Asian and European ancestry. In each dataset we used logistic regression models to test the association between SNPs and breast cancer risk and corrected for genetic ancestry using either principal components or genetic ancestry inferred from ancestry informative markers using a model-based approach.

resultsWe identified a novel set of SNPs at the 6q25 locus associated with genome-wide levels of significance (p = 3.3 × 10

conclusionOur study adds to evidence about the importance of the 6q25 locus for breast cancer susceptibility. Our finding also highlights the utility of performing additional searches for genetic variants for breast cancer in non-European populations.

Indexed as

Genetic Predisposition to DiseaseAdultAgedBreastBreast NeoplasmsCase-Control StudiesChromosome MappingChromosomes, Human, Pair 6Datasets as TopicFemaleGenetic LociGenome-Wide Association StudyHispanic or LatinoHumansMiddle AgedPolymorphism, Single NucleotideFine mappingGenome wide association studyHispanic/Latino populations

Identifiers

PMID30642363
PMCPMC6332913
OpenAlexW2910815862

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.