ArticleMalaria journal2019
Application of the automated haematology analyzer XN-30 for discovery and development of anti-malarial drugs.
Article in Malaria journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Cathagines A-D, new bisindole alkaloids from Catharanthus roseus.Journal of natural medicines · 2025Article
- An adaptable, fit-for-purpose screening approach with high-throughput capability to determine speed of action and stage specificity of anti-malarial compounds.Antimicrobial agents and chemotherapy · 2024Article
- Article
- Ceramicines U-Z from Chisocheton ceramicus and structure-antimalarial activity relationship study.Journal of natural medicines · 2024Article
- A screen of drug-like molecules identifies chemically diverse electron transport chain inhibitors in apicomplexan parasites.PLoS pathogens · 2023Article
- Antimalarial ceramicines Q-T from Chisocheton ceramicus.Journal of natural medicines · 2023Article
- Chukranoids A-I, isopimarane diterpenoids from Chukrasia velutina.Journal of natural medicines · 2022Article
- Clinical performance testing of the automated haematology analyzer XN-31 prototype using whole blood samples from patients with imported malaria in Japan.Malaria journal · 2022Article
- Caloforines A-G, coumarins from the bark of Calophyllum scriblitifolium.Journal of natural medicines · 2022Article
- Fast detection and quantification of Plasmodium species infected erythrocytes in a non-endemic region by using the Sysmex XN-31 analyzer.Malaria journal · 2022Article
- Evaluation of the Sysmex XN-31 automated analyser for blood donor malaria screening at Malawi Blood Transfusion Services.Vox sanguinis · 2022Observational
- Walsogynes H-O from Walsura chrysogyne.Journal of natural medicines · 2022Article
- Two new bisindole alkaloids from Tabernaemontana macrocarpa Jack.Journal of natural medicines · 2021Article
- Performance of the hematology analyzer XN-31 prototype in the detection of Plasmodium infections in an endemic region of Colombia.Scientific reports · 2021Article
- Bisindole alkaloids from Voacanga grandifolia leaves.Journal of natural medicines · 2021Article
- The malaria parasite Plasmodium falciparum in red blood cells selectively takes up serum proteins that affect host pathogenicity.Malaria journal · 2020Article
- A simple monochromatic flow cytometric assay for assessment of intraerythrocytic development of Plasmodium falciparum.Malaria journal · 2020Article
- Sustainable Dissolution Performance of a Carrier Tailored Electrospun.Pharmaceutical research · 2020Article
- Two new sarpagine-type indole alkaloids and antimalarial activity of 16-demethoxycarbonylvoacamine from Tabernaemontana macrocarpa Jack.Journal of natural medicines · 2019Article
- In vitro and in vivo characterization of anti-malarial acylphenoxazine derivatives prepared from basic blue 3.Malaria journal · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe erythrocytic stage of Plasmodium falciparum parasites in humans is clinically important, as the parasites at this growth stage causes malarial symptoms. Most of the currently available anti-malarial drugs target this stage, but the emergence and spread of parasites resistant to anti-malarial drugs are a major challenge to global eradication efforts; therefore, the development of novel medicines is urgently required. In this study, the in vitro anti-malarial activity of five current anti-malarial drugs (artemisinin, atovaquone, chloroquine, mefloquine, and pyrimethamine) and 400 compounds from the Pathogen Box provided by the Medicines for Malaria Venture on P. falciparum parasites was characterized using the XN-30 analyzer. Furthermore, the outcomes obtained using the analyser were classified according to the parasitaemias of total and each developmental stages.
resultsThe growth inhibition rate and the half-maximal (50%) inhibitory concentration (IC
conclusionThe current study demonstrates that the XN-30 analyzer objectively, reproducibly, and easily evaluated and characterized the anti-malarial efficacy of various compounds. The results indicate the potential of the XN-30 analyzer as a powerful tool for drug discovery and development in addition to its use as an important diagnostic tool.
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