Evidence map›Paper›PMID 30642216›Full record

ArticleCirculation. Cardiovascular imaging2019

Michael D Creager, Tobias Hohl, Joshua D Hutcheson, Alastair J Moss, Florian Schlotter, Mark C Blaser, Mi-Ae Park, Lang Ho Lee, Sasha A Singh, Carlos J Alcaide-Corral and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 109 citations in OpenAlex.

  1. Vascular uptake onJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Trial
  2. CoronaryCirculation. Cardiovascular imaging · 2020
    Trial
  3. Coronary artery disease imaging with total-body PET.The British journal of radiology · 2026
    Review
  4. Review
  5. From incidental positron emission uptake toFrontiers in cardiovascular medicine · 2026
    Review
  6. Review
  7. Review
  8. Observational
  9. Review
  10. Temporal changes in biomarker levels and their association with the early degeneration stage of transcatheter aortic valves inPostepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2024
    Article
  11. Article
  12. Article
  13. Aortic sodium [Heart (British Cardiac Society) · 2023
    Article
  14. Scientific reports · 2023
    Article
  15. Temporal Changes in CoronaryJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Diagnostics of atherosclerosis: Overview of the existing methods.Frontiers in cardiovascular medicine · 2023
    Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Commented on by
    2019
5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Michael D CreagerDivision of Cardiovascular Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (M.D.C., T.H., F.S., M.C.B. L.H.L., S.A.S., M.A., E.A.).
Tobias HohlDivision of Cardiovascular Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (M.D.C., T.H., F.S., M.C.B. L.H.L., S.A.S., M.A., E.A.).
Joshua D HutchesonFlorida International University, Miami (J.D.H.).
Alastair J MossBritish Heart Foundation, Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (A.J.M., C.J.A.-C., A.A.S.T., D.E.N., M.R.D.).
Florian SchlotterDivision of Cardiovascular Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (M.D.C., T.H., F.S., M.C.B. L.H.L., S.A.S., M.A., E.A.).
Mark C BlaserDivision of Cardiovascular Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (M.D.C., T.H., F.S., M.C.B. L.H.L., S.A.S., M.A., E.A.).
Mi-Ae ParkDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (M.-A.P., M.F.K., M.D.C.).
Lang Ho LeeDivision of Cardiovascular Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (M.D.C., T.H., F.S., M.C.B. L.H.L., S.A.S., M.A., E.A.).
Sasha A SinghDivision of Cardiovascular Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (M.D.C., T.H., F.S., M.C.B. L.H.L., S.A.S., M.A., E.A.).
Carlos J Alcaide-CorralBritish Heart Foundation, Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (A.J.M., C.J.A.-C., A.A.S.T., D.E.N., M.R.D.).
Adriana A S TavaresBritish Heart Foundation, Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (A.J.M., C.J.A.-C., A.A.S.T., D.E.N., M.R.D.).
David E NewbyBritish Heart Foundation, Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (A.J.M., C.J.A.-C., A.A.S.T., D.E.N., M.R.D.).
Marie F KijewskiDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (M.-A.P., M.F.K., M.D.C.).
Masanori AikawaDivision of Cardiovascular Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (M.D.C., T.H., F.S., M.C.B. L.H.L., S.A.S., M.A., E.A.).
Marcelo Di CarliDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (M.-A.P., M.F.K., M.D.C.).
Marc R DweckBritish Heart Foundation, Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (A.J.M., C.J.A.-C., A.A.S.T., D.E.N., M.R.D.).
Elena AikawaDivision of Cardiovascular Medicine, Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (M.D.C., T.H., F.S., M.C.B. L.H.L., S.A.S., M.A., E.A.).
Harvard University · USBrigham and Women's Hospital · US

Funding

Macrophage-derived microcalcificaitonsR01HL136431 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI AIKAWA, ELENA · 2017 to 2020
$2.7M
Aortic valve microcalcificationR01HL114805 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI AIKAWA, ELENA · 2012 to 2016
$2.1M
Coronary Flow Reserve to Assess Cardiovascular Inflammation (CIRT-CFR)R01HL132021 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DI CARLI, MARCELO F · 2016 to 2018
$1.8M
British Heart Foundation CH/09/002/26360British Heart Foundation FS/14/78/31020British Heart Foundation RG/16/10/32375Chief Scientist Office CGA/17/53NHLBI NIH HHS R01 HL114805NHLBI NIH HHS R01 HL132021NHLBI NIH HHS R01 HL136431Wellcome TrustWellcome Trust WT103782/Z/14/Z
6 · The paper itself

Abstract

backgroundMicrocalcifications in atherosclerotic plaques are destabilizing, predict adverse cardiovascular events, and are associated with increased morbidity and mortality.

methods

resultsMicrocalcification size correlated inversely with collagen concentration. The

conclusionsOur results suggest that

Indexed as

Plaque, AtheroscleroticPositron Emission Tomography Computed TomographyAnimalsAtherosclerosisCarotid Artery DiseasesCells, CulturedCoronary Artery DiseaseDisease Models, AnimalFluorine RadioisotopesHumansMice, KnockoutMolecular ImagingPredictive Value of TestsRadiopharmaceuticalsReceptors, LDLRupture, SpontaneousFluorine RadioisotopesRadiopharmaceuticalsReceptors, LDLatherosclerosisfluoridemicrocalcificationmolecular imagingpositron emission tomography

Identifiers

PMID30642216
PMCPMC6338081
OpenAlexW2909328214

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.