ArticleACS nano2019
Dextran-Coated Iron Oxide Nanoparticles as Biomimetic Catalysts for Localized and pH-Activated Biofilm Disruption.
Article in ACS nano, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.
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The trial behind it
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Who cites it
120 citing papers in PubMed, 345 citations in OpenAlex.
- A Cascade Catalytic Nanoplatform Enabling PTT/CDT Synergistic Antibacterial and Heat-Triggered NO Release for Angiogenesis in Diabetic Wound Healing.International journal of pharmaceutics: X · 2026Article
- Glycan-decorated polymeric nanomedicine for the treatment of multidrug-resistant infections.Bioactive materials · 2026Article
- Exploring the potential of extracellular matrix modulation to modify oral biofilm architecture.Molecular biology reports · 2026Review
- Interappointment pain reduction with three intracanal medicaments: A randomized clinical trial.Journal of conservative dentistry and endodontics · 2026Article
- Chemical and Technological Aspects of Magnetic Particles for Cancer Liquid Biopsy Applications.ChemistryOpen · 2026Review
- Biomimetic Cell Membrane-Based Drug Delivery Systems for Oral Diseases: Engineering Strategies, Targeting Mechanisms, and Translational Challenges.Pharmaceutics · 2026Review
- Sustainable Ag-Cu bimetallic nanozymes derived from Juglans regia husk exhibit multifunctional catalytic, antimicrobial, and antioxidant activities.Scientific reports · 2026Article
- Resiquimod-loaded magnetic nanoparticles reprogram macrophages and induce oxidative cytotoxicity against triple-negative breast cancer cells.International journal of pharmaceutics: X · 2026Article
- Use of Micro/Nanorobots In Vivo for the Eradication of Bacterial Biofilm: A Review of Challenges and Strategies.Nanomaterials (Basel, Switzerland) · 2026Review
- Near infrared light enhanced a green vitamin Cu/Co@MOF laccase-like nanozyme activity for estrogen colorimetric detection.Mikrochimica acta · 2026Article
- Peroxidase-mimicking chitosan/dextran-coated cobalt ferrite-graphene oxide nanozyme enhances hydrogen peroxide-mediated killing of cariogenic pathogens in dental biofilm models.Scientific reports · 2026Article
- Phage-Inspired Artificial Peroxidases with Robust Sub-Nanometer Cluster Sites for Efficient Oral Biofilm Elimination and Dental Caries Prevention.Nano-micro letters · 2026Article
- Scalable flow synthesis of ultrasmall inorganic nanoparticles for biomedical applications via a confined impinging jet mixer.Scientific reports · 2026Article
- Magnetic Field-Driven Strategies for Biofilm Disruption: From Iron Oxide Nanoparticles to Adaptive Swarms of Magnetic Microrobots.ACS nano · 2026Review
- Iron Oxide-Based Magnetic Nanoparticles in Oral Infection Control.International journal of nanomedicine · 2026Review
- pH-responsive nanozymes: multifunctional platforms for biomedical catalysis toward clinical translation.Frontiers in bioengineering and biotechnology · 2026Review
- Smart biomaterials in restorative dentistry: Recent advances and future perspectives.Materials today. Bio · 2025Review
- A MXene-Based Nanothermal Knife Inhibits Aggresome-Mediated Persister Formation for Preventing Dental Caries.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Advances of Nanozyme-Driven Multimodal Sensing Strategies in Point-of-Care Testing.Biosensors · 2025Review
- Amphiphilic Janus nanoparticles for a superhydrophobic coating on the enamel surface to prevent caries.Materials today. Bio · 2025Article
60 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Biofilms are surface-attached bacterial communities embedded within an extracellular matrix that create localized and protected microenvironments. Acidogenic oral biofilms can demineralize the enamel-apatite on teeth, causing dental caries (tooth decay). Current antimicrobials have low efficacy and do not target the protective matrix and acidic pH within the biofilm. Recently, catalytic nanoparticles were shown to disrupt biofilms but lacked a stabilizing coating required for clinical applications. Here, we report dextran-coated iron oxide nanoparticles termed nanozymes (Dex-NZM) that display strong catalytic (peroxidase-like) activity at acidic pH values, target biofilms with high specificity, and prevent severe caries without impacting surrounding oral tissues in vivo. Nanoparticle formulations were synthesized with dextran coatings (molecular weights from 1.5 to 40 kDa were used), and their catalytic performance and bioactivity were assessed. We found that 10 kDa dextran coating provided maximal catalytic activity, biofilm uptake, and antibiofilm properties. Mechanistic studies indicated that iron oxide cores are the source of catalytic activity, whereas dextran on the nanoparticle surface provided stability without blocking catalysis. Dextran-coating facilitated NZM incorporation into exopolysaccharides (EPS) structure and binding within biofilms, which activated hydrogen peroxide (H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.