Evidence map›Paper›PMID 30642117›Full record

ArticleBiosensors2019

Biochemical Changes in Irradiated Oral Mucosa: A FTIR Spectroscopic Study.

Helena Ukkonen, Simo Vuokila, Jopi J W Mikkonen, Hannah Dekker, Engelbert A J M Schulten, Elisabeth Bloemena, Arto Koistinen, Tulio A Valdez, Arja M Kullaa, Surya Pratap Singh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Helena UkkonenResearch Group of Oral Health Sciences, Faculty of Medicine, University of Oulu, and Oulu University Hospital, P.O. Box 8000, 90014 Oulu, Finland. Helena.Ukkonen@oulu.fi.
Simo VuokilaSIB Labs, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland. simovuo@student.uef.fi.
Jopi J W MikkonenSIB Labs, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland. jopi.mikkonen@uef.fi.ORCID 0000-0001-8535-0875
Hannah DekkerAmsterdam UMC and Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam, Department of Oral and Maxillofacial Surgery/Oral Pathology, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. ha.dekker@vumc.nl.
Engelbert A J M SchultenAmsterdam UMC and Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam, Department of Oral and Maxillofacial Surgery/Oral Pathology, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. eajm.schulten@vumc.nl.ORCID 0000-0001-8245-6367
Elisabeth BloemenaAmsterdam UMC and Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam, Department of Oral and Maxillofacial Surgery/Oral Pathology, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. e.bloemena@vumc.nl.ORCID 0000-0002-0221-9538
Arto KoistinenSIB Labs, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland. arto.koistinen@uef.fi.ORCID 0000-0001-7601-9806
Tulio A ValdezDepartment of Otolaryngology, School of Medicine, Stanford University, Patlo Alto, CA 94305, USA. tvaldez1@stanford.edu.
Arja M KullaaResearch Group of Oral Health Sciences, Faculty of Medicine, University of Oulu, and Oulu University Hospital, P.O. Box 8000, 90014 Oulu, Finland. arja.kullaa@uef.fi.
Surya Pratap SinghSIB Labs, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland. spsingh1@stanford.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiation exposure during the course of treatment in head and neck cancer (HNC) patients can induce both structural and biochemical anomalies. The present study is focused on utilizing infrared imaging for the identification of the minor biochemical alterations in the oral mucosa. Chemical maps generated using glycoprotein band indicates its differential distribution along the superficial layer. Spectra extracted from this layer suggests changes in overall nucleic acid and protein content in response to the therapeutic irradiation. Discrimination among control and irradiated groups have been achieved using principal component analysis. Findings of this preliminary study further support prospective utilization of Fourier Transform InfraRed (FTIR) imaging as a non-destructive, label-free tool for objective assessment of the oral mucosa in patient groups with or without radiation therapy.

Indexed as

Spectroscopy, Fourier Transform InfraredAdultAgedAged, 80 and overCase-Control StudiesFemaleHead and Neck NeoplasmsHumansMaleMicroscopyMiddle AgedMouth MucosaPrincipal Component AnalysisRadiation, IonizingFTIR spectroscopyhead and neck cancerradiotherapy

Identifiers

PMID30642117
PMCPMC6468735

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.