Evidence map›Paper›PMID 30642032›Full record

ArticleMolecules (Basel, Switzerland)2019

Potent Antitrypanosomal Activities of 3-Aminosteroids against African Trypanosomes: Investigation of Cellular Effects and of Cross-Resistance with Existing Drugs.

Charles O Nnadi, Godwin U Ebiloma, Jennifer A Black, Ngozi J Nwodo, Leandro Lemgruber, Thomas J Schmidt, Harry P de Koning

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Antiprotozoal Aminosteroids fromMolecules (Basel, Switzerland) · 2025
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  5. The Alkaloid-Enriched Fraction ofMolecules (Basel, Switzerland) · 2021
    Article
  6. Review
  7. Article
  8. Indirubin Analogues InhibitAntimicrobial agents and chemotherapy · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 5 countries.

Charles O NnadiInstitute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Münster, Pharma Campus Corrensstraße 48, D-48149 Münster, Germany. charles.nnadi@unn.edu.ng.ORCID 0000-0001-8749-3431
Godwin U EbilomaInstitute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK. godwin4godwin@gmail.com.ORCID 0000-0003-4072-9800
Jennifer A BlackThe Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow G12 8TA, UK. jennifer.stortz@glasgow.ac.uk.
Ngozi J NwodoDepartment of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria Nsukka, Enugu 410001, Nigeria. ngozi.nwodo@unn.edu.ng.
Leandro LemgruberInstitute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK. Leandro.LemgruberSoares@glasgow.ac.uk.ORCID 0000-0003-2832-6806
Thomas J SchmidtInstitute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Münster, Pharma Campus Corrensstraße 48, D-48149 Münster, Germany. thomschm@uni-muenster.de.ORCID 0000-0003-2634-9705
Harry P de KoningInstitute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK. Harry.De-Koning@glasgow.ac.uk.ORCID 0000-0002-9963-1827
University of Glasgow · GBUniversity of Nigeria · NGKyoto Institute of Technology · JPUniversidade de São Paulo · BRUniversity of Münster · DE

Funding

COST action CM 1307 STSMCOST action CM1307 article podcessing chargeFederal Government of Nigeria/TETFund none
6 · The paper itself

Abstract

Treatment of animal African trypanosomiasis (AAT) requires urgent need for safe, potent and affordable drugs and this has necessitated this study. We investigated the trypanocidal activities and mode of action of selected 3-aminosteroids against

Indexed as

Drug ResistanceAdenosine TriphosphateAnimalsCell CycleCholestanolsInhibitory Concentration 50Intracellular SpaceMembrane Potential, MitochondrialMolecular StructureTrypanocidal AgentsTrypanosoma brucei bruceiTrypanosomiasis, AfricanAdenosine TriphosphateCholestanolsTrypanocidal AgentsAfrican trypanosomiasismode of actionresistant strainsTrypanosoma brucei bruceiTrypanosoma congolense

Identifiers

PMID30642032
PMCPMC6359104
OpenAlexW2909907128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.