ArticleDiagnostics (Basel, Switzerland)2019
Defining System Requirements for Simplified Blood Culture to Enable Widespread Use in Resource-Limited Settings.
Article in Diagnostics (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Facilitating the use of the target product profile in academic research: a systematic review.Journal of translational medicine · 2024Pooled it
- Generating Actionable Data From Antimicrobial Resistance Surveillance: Insights From the Fleming Fund's International Experience.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Review
- Diagnostics for priority bacterial pathogens: global gaps and research needs for curbing antimicrobial resistance in low-resource settings.The Lancet. Microbe · 2026Review
- Global perspective on gaps in fungal diagnostics in low-resource settings: WHO landscape analysis and research priorities for invasive fungal diseases.The Lancet. Microbe · 2026Review
- Evaluation of alternative blood culture systems in detecting pathogenic bacteria: a multi-site, observational prospective study.The Lancet regional health. Western Pacific · 2026Article
- Performance evaluation of the BactInsight simplified blood culture system developed for resource-limited settings using a simulated test design.Scientific reports · 2026Article
- Adherence to Perinatal Asphyxia or Sepsis Management Guidelines in Low- and Middle-Income Countries.JAMA network open · 2025Article
- Advancements of paper-based sensors for antibiotic-resistant bacterial species identification.Npj biosensing · 2024Review
- Blood culture versus antibiotic use for neonatal inpatients in 61 hospitals implementing with the NEST360 Alliance in Kenya, Malawi, Nigeria, and Tanzania: a cross-sectional study.BMC pediatrics · 2023Article
- Use and Quality of Blood Cultures for the Diagnosis of Bloodstream Infections: A Cross-Sectional Study in the Ho Teaching Hospital, Ghana, 2019-2021.International journal of environmental research and public health · 2023Article
- Pilot Testing of the "Turbidimeter", a Simple, Universal Reader Intended to Complement and Enhance Bacterial Growth Detection in Manual Blood Culture Systems in Low-Resource Settings.Diagnostics (Basel, Switzerland) · 2022Article
- Infection prevention and care bundles addressing health care-associated infections in neonatal care in low-middle income countries: a scoping review.EClinicalMedicine · 2022Article
- Considerations in evaluating equipment-free blood culture bottles: A short protocol for use in low-resource settings.PloS one · 2022Article
- Evaluation of a Novel Culture System for Rapid Pathogen Identification and Detection of Cephalosporin Resistance in Neonatal Gram-negative Sepsis at a Tertiary Referral Unit in Harare, Zimbabwe.The Pediatric infectious disease journal · 2021Article
- Blood Culture Testing Outcomes among Non-Malarial Febrile Children at Antimicrobial Resistance Surveillance Sites in Uganda, 2017-2018.Tropical medicine and infectious disease · 2021Article
- Implementation of Automated Blood Culture With Quality Assurance in a Resource-Limited Setting.Frontiers in medicine · 2021Article
- Sepsis-A Retrospective Cohort Study of Bloodstream Infections.Antibiotics (Basel, Switzerland) · 2020Article
- Whole-genome sequencing as part of national and international surveillance programmes for antimicrobial resistance: a roadmap.BMJ global health · 2020Review
- Prioritising pathogens for the management of severe febrile patients to improve clinical care in low- and middle-income countries.BMC infectious diseases · 2020Article
- Implementing COVID-19 (SARS-CoV-2) Rapid Diagnostic Tests in Sub-Saharan Africa: A Review.Frontiers in medicine · 2020Review
Corrections and comments
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Authors and funding
13 authors at 9 institutions in 10 countries.
Funding
Abstract
Bacterial blood stream infections (BSI) are a common cause of mortality and morbidity globally. As the causative agents and the resulting treatment decisions vary, near-patient testing and surveillance tools are necessary to monitor bacterial causes and resistance to antimicrobial agents. The gold standard to identify BSIs is blood culture (BC), a methodology not widely available in resource-limited settings. The aim of the study was to map out a target product profile of a simplified BC system (SBCS) to inform product development efforts. To identify the desired characteristics of a SBCS, we enlisted a small group of specialists working in Africa and Asia. Questions were used to understand challenges and how these constraints inform system requirements. The specialists were infectious disease physicians, public health/clinical microbiologists, clinical researchers, and technology experts with different geographical backgrounds. All suggested that BC should ideally be available at the district hospital level. Many of the same operational challenges, such as limited availability of culture bottles, electricity and internet connectivity, profuse dust, the lack of ambient temperature control, and human capacity constraints were identified across the different regions. BCs, although the accepted gold standard for diagnosis of BSIs, are not widely available outside of reference/research centers in Africa and Asia. To extend the reach of this important tool, it is crucial to engage product developers and academic research partners to develop accessible alternatives.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.