Evidence map›Paper›PMID 30641941›Full record

ArticleNutrients2019

SIRT1 Attenuates Kidney Disorders in Male Offspring Due to Maternal High-Fat Diet.

Long T Nguyen, Crystal H Mak, Hui Chen, Amgad A Zaky, Muh G Wong, Carol A Pollock, Sonia Saad

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Long T NguyenRenal medicine, Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales 2065, Australia. long.t.nguyen@sydney.edu.au.ORCID 0000-0002-0630-4959
Crystal H MakSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales 2007, Australia. Crystal.H.Mak@student.uts.edu.au.
Hui ChenRenal medicine, Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales 2065, Australia. hui.chen-1@uts.edu.au.ORCID 0000-0001-6883-3752
Amgad A ZakyRenal medicine, Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales 2065, Australia. amgadadolf@hotmail.com.
Muh G WongRenal medicine, Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales 2065, Australia. muhgeot.wong@sydney.edu.au.
Carol A PollockRenal medicine, Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales 2065, Australia. carol.pollock@sydney.edu.au.
Sonia SaadRenal medicine, Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales 2065, Australia. sonia.saad@sydney.edu.au.
The University of Sydney · AUUniversity of Technology Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maternal obesity has been associated with kidney disorders in male offspring. Our previous studies have demonstrated that Sirtuin (SIRT)1, an essential regulator of metabolic stress responses, is suppressed in the offspring as the result of maternal high-fat diet (HFD) consumption, which is likely to underpin the adverse metabolic and renal outcomes. To examine if SIRT1 overexpression or activation early in life can protect the offspring kidney, wild-type (WT) and transgenic (Tg) offspring were born to the same diet-induced obese female C57BL/6 mice through breeding with hemizygous SIRT1-transgenic (Tg) male mice and examined for renal pathological changes. In separate experiments, SIRT1 activator SRT1720 (25 mg/kg/2 days i.p) was administrated in WT offspring over 6 weeks of postnatal high-fat diet exposure. The results show that offspring born to obese dams have increased kidney weight, higher levels of renal triglycerides, and increased expression of oxidative stress, inflammatory, and fibrotic markers, as well as increased albuminuria compared to offspring of control dams. Both SIRT1 overexpression and SRT1720 treatment attenuated renal lipid contents and expression of lipogenesis, oxidative stress, and inflammatory markers; however, fibrosis was modestly reduced and albuminuria was not affected. The findings suggest that SIRT1 therapy can ameliorate some pathological mechanisms of kidney programming due to maternal obesity but may not be sufficient to prevent the resulting chronic kidney injury.

Indexed as

Diet, High-FatAlbuminuriaAnimalsBiomarkersCreatinineCyclooxygenase 2FemaleInflammationKidneyKidney DiseasesMaleMaternal Nutritional Physiological PhenomenaMiceMice, Inbred C57BLNitric Oxide Synthase Type IIObesityBiomarkersCreatinineCyclooxygenase 2Nitric Oxide Synthase Type IINos2 protein, mousePtgs2 protein, mouseReactive Nitrogen SpeciesReactive Oxygen SpeciesSirt1 protein, mouseSirtuin 1chronic kidney diseasefoetal programmingObesitysirtuin

Identifiers

PMID30641941
PMCPMC6356703
OpenAlexW2908561034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.