Evidence map›Paper›PMID 30641938›Full record

ArticleInternational journal of molecular sciences2019

Endoplasmic Reticulum Stress Impaired Uncoupling Protein 1 Expression via the Suppression of Peroxisome Proliferator-Activated Receptor γ Binding Activity in Mice Beige Adipocytes.

Ana Yuliana, Asumi Daijo, Huei-Fen Jheng, Jungin Kwon, Wataru Nomura, Haruya Takahashi, Takeshi Ara, Teruo Kawada, Tsuyoshi Goto

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

  1. Deciphering Uncoupling Proteins in Cellular Homeostasis and Metabolic Health.International journal of biological sciences · 2026
    Review
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  18. Nutrients · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ana YulianaLaboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan. anayulia@kais.kyoto-u.ac.jp.
Asumi DaijoLaboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan. asumi.7.9.2.8@gmail.com.
Huei-Fen JhengLaboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan. ydnas@kais.kyoto-u.ac.jp.
Jungin KwonLaboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan. kwon.jungin.34r@st.kyoto-u.ac.jp.
Wataru NomuraLaboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan. nom2@kais.kyoto-u.ac.jp.
Haruya TakahashiLaboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan. haruya@kais.kyoto-u.ac.jp.
Takeshi AraLaboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan. ara@kais.kyoto-u.ac.jp.ORCID 0000-0003-1754-2837
Teruo KawadaLaboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan. fat@kais.kyoto-u.ac.jp.
Tsuyoshi GotoLaboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan. tgoto@kais.kyoto-u.ac.jp.
Kyoto University · JP

Funding

Ministry of Education, Culture, Sports, Science and Technology 16K07734, 16H02551
6 · The paper itself

Abstract

Endoplasmic reticulum (ER) homeostasis is critical in maintaining metabolic regulation. Once it is disrupted due to accumulated unfolded proteins, ER homeostasis is restored via activation of the unfolded protein response (UPR); hence, the UPR affects diverse physiological processes. However, how ER stress influences adipocyte functions is not well known. In this study, we investigated the effect of ER stress in thermogenic capacity of mice beige adipocytes. Here, we show that the expression of uncoupling protein 1 (

Indexed as

Endoplasmic Reticulum StressAdipocytes, BeigeAnimalsCells, CulturedExtracellular Signal-Regulated MAP KinasesJNK Mitogen-Activated Protein KinasesMaleMicePPAR gammaProtein BindingProteolysisTunicamycinUncoupling Protein 1Unfolded Protein ResponseExtracellular Signal-Regulated MAP KinasesJNK Mitogen-Activated Protein KinasesPPAR gammaTunicamycinUcp1 protein, mouseUncoupling Protein 1beige adipocytesendoplasmic reticulum stressperoxisome proliferator-activated receptor γuncoupling protein 1

Identifiers

PMID30641938
PMCPMC6359291
OpenAlexW2910082127

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.