ArticleBiomaterials2019
Injectable mineralized microsphere-loaded composite hydrogels for bone repair in a sheep bone defect model.
Article in Biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Injectable and Cell-Laden Hydrogel in the Contained Bone Defect Animal Model: A Systematic Review.Tissue engineering and regenerative medicine · 2023Pooled it
- ROS-responsive HBioactive materials · 2027Article
- An osteogenesis mimicking biomineralized bone adhesive for rapid skeletal regeneration.Bioengineering & translational medicine · 2026Article
- Innovative Hydroxyapatite-Hydrogel Composites for Cartilage Regeneration.Gels (Basel, Switzerland) · 2026Review
- Engineered Xenogeneic Bone Scaffold with IL-10 Nanodelivery System: Immunomodulation and BMSC Fate Programming for Skull Defect Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Microenvironment engineering with injectable hydrogel-based biofunctional scaffolds for augmenting bone defect regeneration.Journal of nanobiotechnology · 2026Review
- Hydrogels for Bone Repair: Construction Strategies and Applications.Smart medicine · 2026Review
- Biomaterial-assisted gene therapy for bone repair.Materials today. Bio · 2026Review
- The Osteoimmunologic Basis of Biologic and Bioengineered Scaffolds in Fracture Healing.Bioengineering (Basel, Switzerland) · 2026Review
- Hydrogel in musculoskeletal diseases: Unraveling trends, research foci, and future trajectories via bibliometric insights (from 2000 to 2025).Regenerative therapy · 2025Article
- Recent Advances in Injectable Hydrogel Biotherapeutics for Regenerative Dental Medicine.Macromolecular bioscience · 2025Review
- Bioinspired injectable hydrogels for bone regeneration.Journal of advanced research · 2025Review
- Hyaluronic acid-based hydrogel microspheres with multi-responsive properties for antibacterial therapy and bone regeneration inMaterials today. Bio · 2025Article
- Lycium-Barbarum Polysaccharide-Loaded Dual-Crosslinked Rigid Hydrogel Enhances Bone Healing in Diabetic Bone Defects by Scavenging Reactive Oxygen Species.Advanced healthcare materials · 2025Article
- Effects of hydrogel stiffness and viscoelasticity on organoid culture: a comprehensive review.Molecular medicine (Cambridge, Mass.) · 2025Review
- Fabricating oxygen self-supplying 3D printed bioactive hydrogel scaffold for augmented vascularized bone regeneration.Bioactive materials · 2024Article
- β-glycerophosphate, not low magnitude fluid shear stress, increases osteocytogenesis in the osteoblast-to-osteocyte cell line IDG-SW3.Connective tissue research · 2024Article
- Recent Advances in Alginate-Based Hydrogels for Cell Transplantation Applications.Pharmaceutics · 2024Review
- Insights into Translational and Biomedical Applications of Hydrogels as Versatile Drug Delivery Systems.AAPS PharmSciTech · 2024Review
- From the microspheres to scaffolds: advances in polymer microsphere scaffolds for bone regeneration applications.Biomaterials translational · 2024Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The efficacy of cell-based therapies as an alternative to autologous bone grafts requires biomaterials to localize cells at the defect and drive osteogenic differentiation. Hydrogels are ideal cell delivery vehicles that can provide instructional cues via their composition or mechanical properties but commonly lack osteoconductive components that nucleate mineral. To address this challenge, we entrapped mesenchymal stromal cells (MSCs) in a composite hydrogel based on two naturally-derived polymers (alginate and hyaluronate) containing biomineralized polymeric microspheres. Mechanical properties of the hydrogels were dependent upon composition. The presentation of the adhesive tripeptide Arginine-Glycine-Aspartic Acid (RGD) from both polymers induced greater osteogenic differentiation of ovine MSCs in vitro compared to gels formed of RGD-alginate or RGD-alginate/hyaluronate alone. We then evaluated the capacity of this construct to stimulate bone healing when transplanting autologous, culture-expanded MSCs into a surgical induced, critical-sized ovine iliac crest bone defect. At 12 weeks post-implantation, defects treated with MSCs transplanted in composite gels exhibited significant increases in blood vessel density, osteoid formation, and bone formation compared to acellular gels or untreated defects. These findings demonstrate the capacity of osteoconductive hydrogels to promote bone formation with autologous MSCs in a large animal bone defect model and provide a promising vehicle for cell-based therapies of bone healing.
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Registered trials
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