Evidence map›Paper›PMID 30641121›Full record

ArticleAlcohol (Fayetteville, N.Y.)2019

Effects of rat strain and method of inducing ethanol drinking on Pavlovian-Instrumental-Transfer with ethanol-paired conditioned stimuli.

R J Lamb, Brett C Ginsburg, Alexander Greig, Charles W Schindler

Abstract read
In one paragraph

Article in Alcohol (Fayetteville, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Cue-alcohol associative learning in female rats.Alcohol (Fayetteville, N.Y.) · 2019
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

R J LambDepartment of Psychiatry, San Antonio, TX 78229-3900, United States. Electronic address: lamb@uthscsa.edu.
Brett C GinsburgDepartment of Psychiatry, San Antonio, TX 78229-3900, United States.
Alexander GreigDepartment of Psychiatry, San Antonio, TX 78229-3900, United States.
Charles W SchindlerDesigner Drug Unit, Intramural Research Program, National Institute on Drug Abuse, 251 Bayview Blvd., Baltimore, MD 21224, United States.

Funding

Rat ethanol self-administration: respondent instrumental interactionsR01AA012337 · NIAAA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LAMB, RICHARD J · 2001 to 2016
$3.4M
Cognitive flexibility as a target for relapse preventionR01AA025664 · NIAAA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI GINSBURG, BRETT C · 2018 to 2022
$1.7M
NIAAA NIH HHS R01 AA012337NIAAA NIH HHS R01 AA025664
6 · The paper itself

Abstract

Ethanol-paired conditioned stimuli (CSs) are widely thought to invigorate ethanol responding, and thus, precipitate relapse to drinking. However, preclinical studies investigating this issue using Pavlovian-Instrumental-Transfer (PIT) procedures have had mixed results, with some studies finding PIT while others did not. The studies failing to show PIT used Lewis rats and induced ethanol drinking using a post-prandial drinking procedure. The present experiments examined whether either of these two variables influenced the magnitude of PIT observed. In the first experiment, ethanol drinking in Lewis rats was induced using either sucrose fading or post-prandial drinking. In the second experiment, ethanol drinking was induced using post-prandial drinking in either Long-Evans Hooded or Lewis rats. In both experiments, rats were trained to respond for ethanol under a random interval schedule. Subsequently with the lever removed, 2-min light presentations were paired with ethanol deliveries. Finally, with the lever returned, the effect of light presentations on responding was tested while responding was in extinction. Light presentations similarly affected responding in Lewis rats regardless of the method of drinking induction. Likewise, light presentations similarly affected responding in both Lewis and Long-Evans Hooded rats. Neither ethanol induction method nor rat strain affected the magnitude of PIT observed, and thus, neither likely explains previous failures to observe PIT with ethanol-maintained behavior.

Indexed as

Conditioning, ClassicalConditioning, OperantExtinction, PsychologicalTransfer, PsychologyAlcohol DrinkingAnimalsEthanolRatsRats, Inbred LewRats, Long-EvansSelf AdministrationSucroseEthanolSucroseAlcoholismCravingEthanol self-administrationOperant behaviorRelapse

Identifiers

PMID30641121
PMCPMC7201463

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.