ArticleBiological psychology2019
Developmental trajectories of autonomic functioning in autism from birth to early childhood.
Article in Biological psychology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Physiological measurement of emotion from infancy to preschool: A systematic review and meta-analysis.Brain and behavior · 2021Pooled it
- Randomized controlled trial of propranolol on social communication and anxiety in children and young adults with autism spectrum disorder.Psychopharmacology · 2024Trial
- Social Behavior Forecasts Moment-to-Moment Changes in RSA in Infants With Autism.Developmental science · 2026Article
- Alterations in self-related brain networks in autism spectrum disorder: a systematic review of functional and structural magnetic resonance imaging studies.Psychoradiology · 2026Review
- Development of Respiratory Sinus Arrhythmia in Young Infants With Autism Spectrum Disorder, Preterm Birth, and Typical Development.Autism research : official journal of the International Society for Autism Research · 2025Article
- Caregiver report of infant behavior associated with autism likelihood in first year of life.Pediatric research · 2025Article
- Do Infant Heart Rate Variability and Visual Attention Predict Autism and Concerns for ADHD?Journal of attention disorders · 2025Article
- Reduced Respiratory Sinus Arrhythmia in Infants with theInternational journal of molecular sciences · 2025Article
- Reference ranges of gender- and age-related heart rate variability parameters in Russian children.Scientific reports · 2025Article
- Influence of biological maturation on cardiac autonomic recovery in female volleyball players during & after repeated sprints training: An experimental trial.Sports medicine and health science · 2024Article
- A Pilot Feasibility Study Assessing the Combined Effects of Early Behavioral Intervention and Propranolol on Autism Spectrum Disorder (ASD).Children (Basel, Switzerland) · 2023Article
- Prenatal smoking and drinking are associated with altered newborn autonomic functions.Pediatric research · 2023Article
- Negative affect and respiratory sinus arrhythmia are differentially related to social anxiety and autism features in autistic preschoolers contrasted to fragile X syndrome.Frontiers in psychiatry · 2023Article
- Genetic mouse models of autism spectrum disorder present subtle heterogenous cardiac abnormalities.Autism research : official journal of the International Society for Autism Research · 2022Article
- Biological correlates of altered circadian rhythms, autonomic functions and sleep problems in autism spectrum disorder.Annals of general psychiatry · 2022Review
- Maturation of the Cardiac Autonomic Nervous System Activity in Children and Adolescents.Journal of the American Heart Association · 2021Article
- Brief Report: Can a Composite Heart Rate Variability Biomarker Shed New Insights About Autism Spectrum Disorder in School-Aged Children?Journal of autism and developmental disorders · 2021Article
- Trajectories of Heart Activity Across Infancy to Early Childhood Differentially Predict Autism and Anxiety Symptoms in Fragile X Syndrome.Frontiers in psychiatry · 2021Article
- The Brainstem-Informed Autism Framework: Early Life Neurobehavioral Markers.Frontiers in integrative neuroscience · 2021Article
- Emergence and rate of autism in fragile X syndrome across the first years of life.Development and psychopathology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Deficits in social engagement emerge in autism during the infant and toddler period and may be related to emotion regulation and stress response systems. This study examined patterns of growth in autonomic functioning related to autism diagnosis and addresses the hypothesis that there are differences in autonomic functioning related to autism in infancy. Heart rate (HR) and respiratory sinus arrhythmia (RSA) were measured at 8 time points from 1 to 72 months of age in infants later diagnosed with autism (n = 12) and a non-autistic comparison group (n = 106). Multilevel models were used to describe the developmental course of HR and RSA and to test the effect of autism diagnosis on growth trajectories. Both groups showed an expected age-related decrease in HR and increase in RSA. Groups did not differ in the rate of decrease of HR over time. However, infants with autism demonstrated a smaller linear increase in RSA, indicating slower growth in RSA over time in comparison to controls. These results suggest that differences in physiological regulation may develop with age in autism. The slowed RSA growth in autism was most evident after 18 months of age, at a time when behavioral symptoms become prominent. This is consistent with the view that RSA is a marker of functional status in autism rather than a cause of social deficits in autism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.