ArticlePloS one2019
The intestinal fatty acid-binding protein as a marker for intestinal damage in gastroschisis.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 52 citations in OpenAlex.
- Suboptimal vitamin D status and overweight/obesity are associated with gut integrity and inflammation in minority children and adolescents: A cross-sectional analysis from the MetA-bone trial.Nutrition research (New York, N.Y.) · 2025Trial
- Spicy food intake and dietary factors shape the gut microbiome and metabolism of mucin and short-chain fatty acids in healthy adults.Scientific reports · 2026Article
- Molecular and histopathological evaluation of intestinal mucosal damage associated with giardiasis in naturally infected lambs.Journal of advanced veterinary and animal research · 2026Article
- Disruption of oxidant-antioxidant balance and its correlation with intestinal injury and clinical severity in dogs with canine parvoviral gastroenteritis.Molecular biology reports · 2025Article
- Effect of postoperative enteral protein supplementation on nitrogen balance in critically ill children.Clinical and experimental pediatrics · 2025Article
- Insight of Intestinal Fatty Acid Binding Protein as a Potential Biomarker in the Biology of Epithelial Damage of Gastrointestinal Membrane.Current protein & peptide science · 2025Review
- Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging.Microbiome · 2024Article
- Antioxidant supplementation during treatment of outpatient dogs with parvovirus enteritis ameliorates oxidative stress and attenuates intestinal injury: A randomized controlled trial.Veterinary and animal science · 2023Article
- Serum TGF-Journal of immunology research · 2023Article
- Neonatal anemia relates to intestinal injury in preterm infants.Pediatric research · 2022Article
- Peroxisome Proliferator-Activated Receptor-α: A Pivotal Regulator of the Gastrointestinal Tract.Frontiers in molecular biosciences · 2022Review
- Urinary liver-type fatty acid-binding protein variation as a predictive value of short-term mortality in intensive care unit patients.Renal failure · 2021Observational
- The Physiologic Significance of Early Urinary Intestinal Fatty Acid Binding Protein Levels in Preterm Infants: A Prospective Cohort Study.Children (Basel, Switzerland) · 2021Article
- Excessive Matrix Metalloproteinase-1 and Hyperactivation of Endothelial Cells Occurred in COVID-19 Patients and Were Associated With the Severity of COVID-19.The Journal of infectious diseases · 2021Article
- Intestinal fatty acid-binding protein as a biomarker for the diagnosis of strangulated intestinal obstruction: A meta-analysis.Open medicine (Warsaw, Poland) · 2021Article
- Gastroschisis: A State-of-the-Art Review.Children (Basel, Switzerland) · 2020Review
- Urinary I-FABP, L-FABP, TFF-3, and SAA Can Diagnose and Predict the Disease Course in Necrotizing Enterocolitis at the Early Stage of Disease.Journal of immunology research · 2020Article
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Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background/purposeWe analyzed the capacity of urinary Intestinal fatty acid-binding protein (I-FABP) to quantify the degree of mucosal injury in neonates with gastroschisis (GS) and to predict the speed of their clinical recovery after surgery.
methodsIn this prospective study, we collected urine during the first 48h after surgery from neonates operated between 2012 and 2015 for GS. Neonates with surgery that did not include gut mucosa served as controls for simple GS and neonates with surgery for intestinal atresia served as control for complex GS patients. The I-FABP levels were analyzed by ELISA.
resultsUrinary I-FABP after the surgery is significantly higher in GS newborns than in control group; I-FABP in complex GS is higher than in simple GS. I-FABP can predict subsequent operation for ileus in patients with complex GS. Both ways of abdominal wall closure (i.e. primary closure and stepwise reconstruction) led to similar levels of I-FABP. None of the static I-FABP values was useful for the outcome prediction. The steep decrease in I-FABP after the surgery is associated with faster recovery, but it cannot predict early start of minimal enteral feeding, full enteral feeding or length of hospitalization.
conclusionUrinary I-FABP reflects the mucosal damage in gastroschisis but it has only a limited predictive value for patients' outcome.
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