ArticlePloS one2019
Effect of length of time from diagnosis to treatment on colorectal cancer survival: A population-based study.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 4 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Treatment delay significantly increases mortality in colorectal cancer: a meta-analysis.GeroScience · 2025Pooled it
- The effect of time before diagnosis and treatment on colorectal cancer outcomes: systematic review and dose-response meta-analysis.British journal of cancer · 2023Pooled it
- Delay to elective colorectal cancer surgery and implications for survival: a systematic review and meta-analysis.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2021Pooled it
- Conflicting Guidelines: A Systematic Review on the Proper Interval for Colorectal Cancer Treatment.World journal of surgery · 2021Pooled it
- Cost-effectiveness analysis of pembrolizumab versus chemotherapy as first-line treatment for mismatch-repair-deficient (dMMR) or microsatellite-instability-high (MSI-H) advanced or metastatic colorectal cancer from the perspective of the Chinese health-care system.BMC health services research · 2023Trial
- Colorectal cancer surgery without preoperative histology does not compromise surgical quality-A nationwide cohort study.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026Article
- Colorectal Cancer Treatment Delay Thresholds and Metastasis Risk.JAMA network open · 2026Article
- Article
- Influence of Diagnostic and Treatment Delays on Survival Outcomes in Patients With Locally Advanced Rectal Cancer: A Multi-Center Retrospective Cohort Study.Cancer medicine · 2026Article
- Preoperative social frailty and short-term postoperative outcomes in gastrointestinal cancer surgery: a multicentre prospective cohort study in China.World journal of surgical oncology · 2026Observational
- Article
- Real-world data and clinical experience from over 100,000 multi-cancer early detection tests.Nature communications · 2025Article
- Comprehensive Analysis of Factors Associated with Treatment Delays in Asian, Native Hawaiian, and Other Pacific Islander Patients with Colorectal Cancer.Journal of gastrointestinal cancer · 2025Article
- Experience-based co-design of an active case finding service for colorectal cancer in community pharmacies: findings from a focused ethnography.Research involvement and engagement · 2025Article
- Prognostic role of tumor microenvironment and immune- and autophagy-related genes in colorectal adenocarcinoma.Translational cancer research · 2025Article
- Longitudinal retrospective study of real-world adherence to colorectal cancer screening before and after the COVID-19 pandemic in the USA.BMJ public health · 2025Article
- Impact of Multimorbidity Burden on Mortality Risk among Colon Cancer Survivors.Journal of Cancer · 2025Article
- Screening of prognostic factors and survival analysis based on histological type for perimenopausal endometrial carcinoma treated with hysterectomy.Discover oncology · 2024Article
- Impact of COVID-19 pandemic on bone and soft tissue sarcoma patients' consultation and diagnosis.Scientific reports · 2024Article
- Factors linked to prognosis in children with provisional tic disorder: a prospective cohort study.European journal of pediatrics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence is limited regarding the effect of diagnosis-to-treatment interval (DTI) on the survival of colorectal cancer (CRC) patients. In addition, previous studies on treatment delay and CRC survival have largely grouped patients from all stages (I-IV) into one cohort. Our study provides analysis on each stage individually. We conducted a retrospective cohort study with 39,000 newly diagnosed CRC patients obtained from the Taiwan Cancer Registry Database from 2004-2010 to examine the effect of DTIs on overall survival. DTIs were divided into 3 groups: ≤ 30 days (36,115 patients, 90.5% of study patients), 31-150 days (2,533, 6.4%), and ≥ 151 days (1,252, 3.15%). Risk of death was increased for DTI 31-150 days (hazard ratio 1.51; 95% confidence interval 1.43-1.59) and DTI ≥ 151 days (1.64; 1.54-1.76) compared to DTI ≤ 30. This risk was consistent across all cancer stages. Additional factors that increased risk of death include male gender, age >75, Charlson Comorbidity Index ≥7, other catastrophic illnesses, lack of multidisciplinary team involvement, and treatment in a low volume center. From these results, we advise that the DTI for all CRC patients, regardless of cancer staging, should be 30 days or less.
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