ArticlePsychoneuroendocrinology2019
Oxytocin administration prevents cellular aging caused by social isolation.
Article in Psychoneuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Pooled it
- Oxytocin enhances neurogenesis and synaptic plasticity to attenuate age-related cognitive decline in aged mice.IBRO neuroscience reports · 2025Article
- Reunion with a peer partner reduces PVN oxytocin neuron immunoreactivity in socially selective voles.Scientific reports · 2025Article
- Sociodemographic, Lifestyle, and Social Isolation Correlates of TyG, METS-IR, and SPISE-IR Scores in a Large Spanish Working Population.Medical sciences (Basel, Switzerland) · 2025Article
- Complexity of the Hypothalamic Oxytocin System and its Involvement in Brain Functions and Diseases.Neuroscience bulletin · 2025Review
- Association between oxytocin and S100B in community-dwelling older adults.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Spatiotemporal profiling reveals the impact of caloric restriction on mammalian brain aging.bioRxiv : the preprint server for biology · 2025Article
- The dynamic relationship of brain-derived neurotrophic factor and oxytocin: Introducing the concept of neurosocial plasticity.Neuroprotection (Chichester, England) · 2025Review
- Birds of a feather age together: telomere dynamics and social behavior predict life span in female Japanese quailFrontiers in endocrinology · 2024Article
- Therapeutic uses of oxytocin in stress-related neuropsychiatric disorders.Cell & bioscience · 2023Review
- To promote healthy aging, focus on the environment.Nature aging · 2023Review
- Shared and distinct structural brain networks related to childhood maltreatment and social support: connectome-based predictive modeling.Molecular psychiatry · 2023Article
- Attachment across the lifespan: Examining the intersection of pair bonding neurobiology and healthy aging.Neuroscience and biobehavioral reviews · 2023Review
- Oxytocin prevents dysregulation of the acute stress response and glucocorticoid-induced oxidative stress in chronically isolated prairie voles.Psychoneuroendocrinology · 2023Article
- Sex, love and oxytocin: Two metaphors and a molecule.Neuroscience and biobehavioral reviews · 2022Review
- Dynamic influences on the neural encoding of social valence.Nature reviews. Neuroscience · 2022Review
- Social isolation and oxytocin antagonism increase emotion-related behaviors and heart rate in female prairie voles.Autonomic neuroscience : basic & clinical · 2022Article
- Oxytocin and vasopressin: Signalling, behavioural modulation and potential therapeutic effects.British journal of pharmacology · 2022Review
- Chronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives.Psychopharmacology · 2022Review
- Oxytocin and love: Myths, metaphors and mysteries.Comprehensive psychoneuroendocrinology · 2022Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Chronic stressors, such as chronic isolation in social mammals, can elevate glucocorticoids, which can affect cellular mechanisms of aging, including increased levels of oxidative stress and shortened telomere lengths. Recent work in the selectively social prairie vole (Microtus ochrogaster) suggests that oxytocin and social support may mitigate some of the negative consequences of social isolation, possibly by reducing glucocorticoid levels. We investigated the influences of isolation, social support, and daily oxytocin injections in female prairie voles. Glucocorticoid levels, oxidative damage, telomere length, and anhedonia, a behavioral index of depression, were measured throughout the study. We found that six weeks of chronic isolation led to increased glucocorticoid levels, oxidative damage, telomere degradation and anhedonia. However, daily oxytocin injections in isolated voles prevented these negative consequences. These findings demonstrate that chronic social isolation in female prairie voles is a potent stressor that results in depression-like behavior and accelerated cellular aging. Importantly, oxytocin can completely prevent the negative consequences of social isolation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.