ArticleAppetite2019
Altering salivary protein profile can increase acceptance of a novel bitter diet.
Article in Appetite, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- Functional bitter taste signaling and stimulus intensity influence diet-induced salivary protein upregulation.Appetite · 2026Article
- Article
- Bitter and Sweet Diets Alter Taste Response and Alcohol Consumption Behavior in Mice.Nutrients · 2025Article
- Patterns of ingestion of rats during chronic oral administration of lithium chloride.Physiology & behavior · 2024Article
- Salivary proteins rescue within-session suppression and conditioned avoidance in response to an intragastric quinine infusion.Physiology & behavior · 2024Article
- The Influence of (Poly)phenol Intake in Saliva Proteome: Short- and Medium-Term Effects of Apple.Foods (Basel, Switzerland) · 2023Article
- The role of saliva in taste and food intake.Physiology & behavior · 2023Review
- Salivary flow and turbidity development inconsistently associated with lower taste intensity of vegetables and juices.Food quality and preference · 2023Article
- Understanding If Differences in Salivary Flow Rate and Total Protein Content Triggered by Biological Factors (Sex and Age) Affect Aroma Perception and the Hedonic and Emotional Response of Wine Consumers.Foods (Basel, Switzerland) · 2022Article
- Saliva changes in composition associated to COVID-19: a preliminary study.Scientific reports · 2022Article
- Associations among fatty food sensations and saliva's emulsifying properties.Chemical senses · 2022Article
- Repeated exposure to epigallocatechin gallate solution or water alters bitterness intensity and salivary protein profile.Physiology & behavior · 2021Article
- How Different Snacks Produce a Distinct Effect in Salivary Protein Composition.Molecules (Basel, Switzerland) · 2021Article
- Observational
- Salivary Protein Profile and Food Intake: A Dietary Pattern Analysis.Journal of nutrition and metabolism · 2021Article
- Addition of chocolate milk to diet corresponds to protein concentration changes in human saliva.Physiology & behavior · 2020Article
- Altering salivary protein profile can decrease aversive oromotor responding to quinine in rats.Physiology & behavior · 2020Article
- Bitter-Induced Salivary Proteins Increase Detection Threshold of Quinine, But Not Sucrose.Chemical senses · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Bitter taste is often associated with toxins, but accepting some bitter foods, such as green vegetables, can be an important part of maintaining a healthy diet. In rats and humans, repeated exposure to a bitter stimulus increases acceptance. Repeated exposure allows an individual the opportunity to learn about the food's orosensory and postingestive effects. It also alters the salivary protein (SP) profile, which in turn alters taste signaling. We have hypothesized that altering the salivary proteome plays a role in the increased acceptance after repeated exposure. Here we test this and attempt to disentangle the contribution of learning during dietary exposure from the contribution of SPs in increased acceptance of bitter diet. Dietary exposure to quinine or tannic acid and injection of isoproterenol (IPR) result in similar salivary protein profiles. Here we used either the bitter stimulus tannic acid or IPR injection to upregulate a subset of SPs before exposing animals to a novel diet containing quinine (0.375%). Control animals received either a control diet before being exposed to quinine, or a diet containing sucrose octaacetate, a compound that the animals avoid but does not alter SP profiles. The treatments that alter SP expression increased rate of feeding on the quinine diet compared to the control treatments. Additionally, tannic acid exposure altered intake and meal size of the quinine diet. These data suggest that SPs, not just learning about bitter food, increase acceptance of the bitter diet.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.