Evidence map›Paper›PMID 30639614›Full record

ArticleFree radical biology & medicine2019

Differential peroxiredoxin hyperoxidation regulates MAP kinase signaling in human articular chondrocytes.

John A Collins, Scott T Wood, Jesalyn A Bolduc, N P Dewi Nurmalasari, Susan Chubinskaya, Leslie B Poole, Cristina M Furdui, Kimberly J Nelson, Richard F Loeser

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free radical biology & medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  3. Cartilage-specificAnnals of the rheumatic diseases · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

John A CollinsDivision of Rheumatology, Allergy and Immunology and the Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Scott T WoodDivision of Rheumatology, Allergy and Immunology and the Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Nanoscience and Nanoengineering, South Dakota School of Mines and Technology, BioSNTR, Rapid City, SD, USA.
Jesalyn A BolducDivision of Rheumatology, Allergy and Immunology and the Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
N P Dewi NurmalasariNanoscience and Nanoengineering, South Dakota School of Mines and Technology, BioSNTR, Rapid City, SD, USA.
Susan ChubinskayaDepartment of Pediatrics, Rush University Medical Center, Chicago, IL, USA.
Leslie B PooleDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Cristina M FurduiDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Kimberly J NelsonDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Richard F LoeserDivision of Rheumatology, Allergy and Immunology and the Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: richard_loeser@med.unc.edu.
University of North Carolina at Chapel Hill · USWake Forest University · USSouth Dakota School of Mines and Technology · USRush University Medical Center · US

Funding

Oxidative Stress and the Development of OsteoarthritisR01AG044034 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RICHARD F LOESER · 2012 to 2026
$5.7M
Mechanisms and Regulation of PeroxiredoxinsR01GM119227 · NIGMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI POOLE, LESLIE B · 2016 to 2019
$1.4M
NIA NIH HHS R01 AG044034NIGMS NIH HHS R01 GM119227
6 · The paper itself

Abstract

The peroxiredoxin (Prx) family of Cys-dependent peroxidases control intracellular levels of H

Indexed as

Oxidative StressAntifibrinolytic AgentsCartilage, ArticularCells, CulturedChondrocytesHomeodomain ProteinsHumansHydrogen PeroxideMitochondriaMitogen-Activated Protein KinasesOxidation-ReductionPhosphorylationSignal TransductionVitamin K 3Antifibrinolytic AgentsHomeodomain ProteinsHydrogen PeroxideMitogen-Activated Protein KinasesPRRX1 protein, humanPRRX2 protein, humanVitamin K 3CartilageMAP kinase signalingOsteoarthritisOxidative stressPeroxiredoxinRedox signaling

Identifiers

PMID30639614
PMCPMC6588440
OpenAlexW2908992306

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.