Observational studyThe journal of pain2019
Enrichment of Genomic Pathways Based on Differential DNA Methylation Associated With Chronic Postsurgical Pain and Anxiety in Children: A Prospective, Pilot Study.
Observational study in The journal of pain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Transient Receptor Potential Ankyrin 1 (TRPA1) Methylation and Chronic Pain: A Systematic Review.Genes · 2023Pooled it
- Systematic Review and Meta-Analysis of Genetic Risk of Developing Chronic Postsurgical Pain.The journal of painPooled it
- Identification of a different DNA methylation pattern for pain related genes in children with intellectual disability: a cross-sectional study.Italian journal of pediatrics · 2026Article
- Presurgical Prognostic Factors for Chronic Postsurgical Pain Across Developmental Stages in Children, Adolescents, and Young Adults: A Systematic Review and Meta-Analysis.Journal of pain research · 2026Review
- Potential role for immune cell signatures as predictors of acute and chronic pain in adolescents post major musculoskeletal surgery.Brain, behavior, and immunity · 2026Observational
- Chronic postsurgical pain in young children: Prevalence, pain trajectories and physical and psychological prognostic factors.The journal of pain · 2025Observational
- Mechanisms and management of self-resolving lumbar disc herniation: bridging molecular pathways to non-surgical clinical success.Journal of orthopaedic surgery and research · 2025Review
- Observational
- The role of cytokines in acute and chronic postsurgical pain after major musculoskeletal surgeries in a quaternary pediatric center.Brain, behavior, and immunity · 2024Observational
- Macrophage memories of early-life injury drive neonatal nociceptive priming.Cell reports · 2024Article
- The Role of Cytokines in Acute and Chronic Postsurgical Pain in Pediatric Patients after Major Musculoskeletal Surgeries.medRxiv : the preprint server for health sciences · 2024Article
- Current Evidence for Biological Biomarkers and Mechanisms Underlying Acute to Chronic Pain Transition across the Pediatric Age Spectrum.Journal of clinical medicine · 2023Article
- Development and expansion of a pediatric transitional pain service to prevent complex chronic pain.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Genetic and epigenetic mechanisms influencing acute to chronic postsurgical pain transitions in pediatrics: Preclinical to clinical evidence.Canadian journal of pain = Revue canadienne de la douleur · 2022Review
- Pediatric Pain Screening Tool: A Simple 9-Item Questionnaire Predicts Functional and Chronic Postsurgical Pain Outcomes After Major Musculoskeletal Surgeries.The journal of pain · 2022Observational
- A step towards understanding disparities - linking race, ancestry, epigenetics and pain.Epigenomics · 2021Article
- Methylation quantitative trait locus analysis of chronic postsurgical pain uncovers epigenetic mediators of genetic risk.Epigenomics · 2021Article
- Postoperative Pain Management in Pediatric Spinal Fusion Surgery for Idiopathic Scoliosis.Paediatric drugs · 2020Review
- DNA methylation biomarkers of future health outcomes in children.Molecular and cellular pediatrics · 2020Review
- Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
We have reported child anxiety sensitivity (Child Anxiety Sensitivity Index [CASI]) predicts chronic postsurgical pain (CPSP). Herein, we evaluated DNA methylation profiles to understand the gene-environment interactions underlying CPSP and CASI, to identify shared, enriched, genomic pathways. In 73 prospectively recruited adolescents undergoing spine fusion, preoperative CASI and pain data over 12 months after surgery were collected. DNA from the peripheral blood of evaluable subjects with (n = 16) and without CPSP (n = 40) were analyzed using MethylationEPIC arrays. We identified 637 and 2,445 differentially DNA methylated positions (DMPs) associated with CPSP and CASI, respectively (P ≤ .05). Ingenuity pathway analysis of 39 genes with DMPs for both CPSP and CASI revealed enrichment of several canonical pathways, including GABA receptor (P = .00016 for CPSP; P =.0008 for CASI) and dopamine-DARPP32 feedback in cyclic adenosine monophosphate (P = .004 for CPSP and P =.00003 for CASI) signaling. Gene-gene interaction network enrichment analysis revealed participation of pathways in cell signaling, molecular transport, metabolism, and neurologic diseases (P < 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.