ArticleCell metabolism2019
GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans.
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Article in Cell metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 303 papers, 3 of them syntheses that pooled it.
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303citing papers in PubMed, 3 pooled it
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Who cites it
303 citing papers in PubMed, 3 syntheses or guidelines pooled it, 480 citations in OpenAlex.
- A systematic review of the neuroprotective role and biomarker potential of GDF15 in neurodegeneration.Frontiers in immunology · 2024Pooled it
- Unraveling the Interplay between Nonalcoholic Fatty Liver Disease and Polycystic Ovary Syndrome in Adolescents: Pathogenesis, Prevalence, and Management Strategies.Medical science monitor : international medical journal of experimental and clinical research · 2023Pooled it
- Pooled it
- Metformin increases glycolysis and the stress-induced cytokine GDF15 but not FGF21 in humans.Frontiers in endocrinology · 2026Trial
- Alterations in Biomarkers Associated with Cardiovascular Health and Obesity with Short-Term Lifestyle Changes in Overweight Women: The Role of Exercise and Diet.Medicina (Kaunas, Lithuania) · 2024Trial
- Aerobic exercise elevates perceived appetite but does not modify energy intake over a 3-day postexercise period: A pilot study.Physiological reports · 2024Trial
- Growth differentiation factor 15 is not associated with glycemic control in patients with type 2 diabetes mellitus treated with metformin: a post-hoc analysis of AIM study.BMC endocrine disorders · 2022Trial
- Circulating total and intact GDF-15 levels are not altered in response to weight loss induced by liraglutide or lorcaserin treatment in humans with obesity.Metabolism: clinical and experimental · 2022Trial
- Moderate iron restriction improves metabolism via epigenetic regulation of GDF15.The Journal of nutritional biochemistry · 2026Article
- Investigation of Endoplasmic Reticulum Stress in Pregnant Women with Hyperemesis Gravidarum.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Investigation of Endoplasmic Reticulum Stress in Pregnant Women with Hyperemesis Gravidarum.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Lipid sensing and brain hormone receptors in food intake and glucose regulation.Nature reviews. Endocrinology · 2026Review
- The causes of cachexia: key signals and the brain.Nature reviews. Endocrinology · 2026Review
- Molecular mechanisms and pathogenesis of MASH.Nature · 2026Review
- Emerging Myostatin and Metabolic Hormone Pathway Modulators in Cardiometabolic Disease: Mechanisms, Evidence, and Therapeutic Potential.Journal of cardiovascular translational research · 2026Review
- Growth Hormone-Insulin-like Growth Factor Axis and GDF-15 in Critical Illness: Implications for Survival Stratification.Life (Basel, Switzerland) · 2026Article
- GDF15: A Hijacked Metabo-Hormone Orchestrating Cachexia and Immunosuppression in Cancer.Biomolecules · 2026Review
- Reductive Stress and Dysregulated Energy Metabolism in Schizophrenia: Mechanisms and Therapeutic Targets.Biological psychiatry · 2026Review
- Molecular damage associated with ageing drives inflammation in cardiovascular disease.Nature reviews. Cardiology · 2026Review
- Adipokine-mediated metabolic responses across BMI in acute myocardial infarction.BMC cardiovascular disorders · 2026Article
243 more citing papers are in PubMed but not listed here.
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Authors and funding
36 authors at 13 institutions in 5 countries.
Satish PatelMetabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Anna Alvarez-GuaitaMetabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Audrey MelvinMetabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Debra RimmingtonMetabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Alessia DattiloMetabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Emily L MiedzybrodzkaMetabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Irene CiminoMetabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Anne-Catherine MaurinINRA, Unité de Nutrition Humaine, Université Clermont Auvergne, 63000 Clermont-Ferrand, France.
Geoffrey P RobertsMetabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Claire L MeekMetabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Samuel VirtueMetabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Lauren M SparksTranslational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, FL, USA.
Stephanie A ParsonsTranslational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, FL, USA.
Leanne M RedmanPennington Biomedical Research Center, Baton Rouge, LA, USA.
George A BrayPennington Biomedical Research Center, Baton Rouge, LA, USA.
Alice P LiouInternal Medicine Research Unit, Pfizer Global R&D, 1 Portland Street, Cambridge, MA, USA.
Rachel M WoodsSchool of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, Leicestershire LE11 3TU, UK.
Sion A ParrySchool of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, Leicestershire LE11 3TU, UK.
Per B JeppesenDepartment of Clinical Medicine, Aarhus University Hospital, Aarhus University, Aarhus, Denmark.
Anders J KolnesSection of Specialized Endocrinology, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Heather P HardingMetabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK; Cambridge Institute for Medical Research, Cambridge University, Cambridge CB2 0XY, UK.
David RonMetabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK; Cambridge Institute for Medical Research, Cambridge University, Cambridge CB2 0XY, UK.
Antonio Vidal-PuigMetabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Frank ReimannMetabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Fiona M GribbleMetabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Carl J HulstonSchool of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, Leicestershire LE11 3TU, UK.
I Sadaf FarooqiMetabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Pierre FafournouxINRA, Unité de Nutrition Humaine, Université Clermont Auvergne, 63000 Clermont-Ferrand, France.
Steven R SmithTranslational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, FL, USA.
Jorgen JensenDepartment of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway.
Danna BreenInternal Medicine Research Unit, Pfizer Global R&D, 1 Portland Street, Cambridge, MA, USA.
Zhidan WuInternal Medicine Research Unit, Pfizer Global R&D, 1 Portland Street, Cambridge, MA, USA.
Bei B ZhangInternal Medicine Research Unit, Pfizer Global R&D, 1 Portland Street, Cambridge, MA, USA.
Anthony P CollMetabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
David B SavageMetabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK. Electronic address: dbs23@medschl.cam.ac.uk.
Stephen O'RahillyMetabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK. Electronic address: so104@medschl.cam.ac.uk.
University of Cambridge · GBWellcome/MRC Institute of Metabolic Science · GBPfizer (United States) · USWellcome Trust · GBLoughborough University · GBMedical Research Council · GBTranslational Research Institute for Metabolism and Diabetes · USPennington Biomedical Research Center · USAarhus University Hospital · DKNorwegian School of Sport Sciences · NOOslo University Hospital · NOUnité de Nutrition Humaine · FRUniversité Clermont Auvergne · FR
Funding
Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1MBritish Heart Foundation RG/12/13/29853Department of HealthMedical Research Council G0400192Medical Research Council G0600717Medical Research Council G0802051Medical Research Council G0900554Medical Research Council G9824984Medical Research Council MC_UU_00014/1Medical Research Council MC_UU_00014/2Medical Research Council MC_UU_00014/3Medical Research Council MC_UU_00014/5Medical Research Council MC_UU_12012/1Medical Research Council MC_UU_12012/2Medical Research Council MC_UU_12012/3Medical Research Council MC_UU_12012/5NIGMS NIH HHS U54 GM104940Wellcome Trust 095515/Z/11/ZWellcome Trust 098497/Z/12/ZWellcome Trust 100140Wellcome Trust 100574/Z/12/ZWellcome Trust 106262/Z/14/ZWellcome Trust 106263/Z/14/ZWellcome Trust 107064Wellcome Trust 200848/Z/16/ZWellcome Trust WT 107064
Abstract
GDF15 is an established biomarker of cellular stress. The fact that it signals via a specific hindbrain receptor, GFRAL, and that mice lacking GDF15 manifest diet-induced obesity suggest that GDF15 may play a physiological role in energy balance. We performed experiments in humans, mice, and cells to determine if and how nutritional perturbations modify GDF15 expression. Circulating GDF15 levels manifest very modest changes in response to moderate caloric surpluses or deficits in mice or humans, differentiating it from classical intestinally derived satiety hormones and leptin. However, GDF15 levels do increase following sustained high-fat feeding or dietary amino acid imbalance in mice. We demonstrate that GDF15 expression is regulated by the integrated stress response and is induced in selected tissues in mice in these settings. Finally, we show that pharmacological GDF15 administration to mice can trigger conditioned taste aversion, suggesting that GDF15 may induce an aversive response to nutritional stress.
Indexed as
AdultAnimalsCell LineDiet, High-FatEnergy IntakeGrowth Differentiation Factor 15HumansMiceMice, Inbred C57BLMiddle AgedYoung AdultGDF15 protein, humanGdf15 protein, mouseGrowth Differentiation Factor 15conditioned taste aversionGDF15GFRALintegrated stress responseovernutrion
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.