Evidence map›Paper›PMID 30639346›Full record

ArticleThe Journal of allergy and clinical immunology2019

Report from the National Institute of Allergy and Infectious Diseases workshop on "Atopic dermatitis and the atopic march: Mechanisms and interventions".

Wendy F Davidson, Donald Y M Leung, Lisa A Beck, Cecilia M Berin, Mark Boguniewicz, William W Busse, Talal A Chatila, Raif S Geha, James E Gern, Emma Guttman-Yassky and 15 more

Abstract readConference Proceedings
In one paragraph

Article in The Journal of allergy and clinical immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 4 pooled it
22.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 4 syntheses or guidelines pooled it, 193 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Emollient application from birth to prevent eczema in high-risk children: the BEEP RCT.Health technology assessment (Winchester, England) · 2024
    Trial
  7. Trial
  8. Review
  9. Article
  10. Subtype-Specific Efficacy of TopicalAllergy, asthma & immunology research · 2026
    Article
  11. Revisiting Atopy: The IgE-Dependent Amplification Loop as a Forgotten Driver of Atopic Dermatitis.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
  12. Development of a pediatric immune cell atlas and characterization of CD4+ T cells in food allergy.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Review
  13. The Role of OX40 Pathway Inhibition as a New Therapeutic Strategy for Atopic Dermatitis.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  14. Article
  15. Review
  16. Skin-lung axis in the atopic march: The immune link from skin to lungs.Chinese medical journal pulmonary and critical care medicine · 2025
    Review
  17. The journal of allergy and clinical immunology. Global · 2025
    Article
  18. Article
  19. Article
  20. Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 19 institutions in 4 countries.

Wendy F DavidsonNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Md.
Donald Y M LeungDepartment of Pediatrics, National Jewish Health, Denver, and the Department of Pediatrics, University of Colorado at Denver Health Sciences Center, Aurora, Colo. Electronic address: LeungD@njhealth.org.
Lisa A BeckUniversity of Rochester Medical Center, Rochester, NY.
Cecilia M BerinDepartment of Pediatrics, Mindich Child Health and Development Institute, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Mark BoguniewiczDepartment of Pediatrics, National Jewish Health, Denver, and the University of Colorado School of Medicine, Aurora, Colo.
William W BusseUniversity of Wisconsin School of Medicine and Public Health, Madison, Wis.
Talal A ChatilaDivision of Immunology, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Raif S GehaDivision of Immunology, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Mass.
James E GernUniversity of Wisconsin School of Medicine and Public Health, Madison, Wis.
Emma Guttman-YasskyDepartment of Dermatology and the Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, and the Laboratory for Investigative Dermatology, Rockefeller University, New York, NY.
Alan D IrvinePaediatric Dermatology, Our Lady's Children's Hospital, Crumlin, National Children's Research Centre and Trinity College, Dublin, Ireland.
Brian S KimCenter for the Study of Itch, the Division of Dermatology, Department of Medicine, the Department of Anesthesiology, and the Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Mo.
Heidi H KongDermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Md.
Gideon LackPaediatric Allergy, Department of Women and Children's Health, Peter Gorer Department of Immunobiology, School of Life Course Sciences, Faculty of Life Sciences & Medicine, King's College London, Guy's & St. Thomas' NHS Foundation Trust, London, United Kingdom.
Kari C NadeauSean N. Parker Center for Allergy and Asthma Research at Stanford University, and the Department of Medicine Department of Pediatrics, Stanford University, Stanford, Calif.
Julie SchwaningerNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Md.
Angela SimpsonDivision of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Eric L SimpsonDepartment of Dermatology, Oregon Health & Science University, Portland, Ore.
Jonathan M SpergelDepartment of Pediatrics, Division of Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, and the Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa.
Alkis TogiasNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Md.
Ulrich WahnDepartment of Pediatric Pneumology and Immunology, Charité, Berlin, Germany.
Robert A WoodJohns Hopkins University School of Medicine, Baltimore, Md.
Judith A WoodfolkDepartment of Medicine, University of Virginia School of Medicine, Charlottesville, Va.
Steven F ZieglerImmunology Program, Benaroya Research Institute, Seattle, Wash.
Marshall PlautNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Md.
National Institute of Allergy and Infectious Diseases · USBoston Children's Hospital · USIcahn School of Medicine at Mount Sinai · USUniversity of Wisconsin–Madison · USBenaroya Research InstituteCenter for Cancer Research · USCharité - Universitätsmedizin Berlin · DEChildren's Hospital of Philadelphia · USDenver Health Medical Center · USJohns Hopkins University · USKing's College London · GBNational Children’s Research Centre · IEOregon Health & Science University · USStanford University · USUniversity of Colorado Denver · USUniversity of Manchester · GBUniversity of Rochester Medical Center · USUniversity of Virginia · USWashington University in St. Louis · US

Funding

Studies of Skin Microflora in Healthy Individuals and Atopic Dermatitis PatientsZIABC010938 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KONG, HEIDI · 2009 to 2021
$5.4M
Immunological and Microbial Mechanisms in Food AllergyR01AI126915 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI Talal Amine Chatila, Seth Rakoff-Nahoum · 2017 to 2026
$4.9M
Neuroimmune Regulation of Atopic DermatitisR01AR070116 · NIAMS · WASHINGTON UNIVERSITY · PI KIM, BRIAN · 2016 to 2021
$3.8M
Innate Immune Regulation of Skin InflammationK08AR065577 · NIAMS · WASHINGTON UNIVERSITY · PI KIM, BRIAN · 2014 to 2018
$711k
Planning a Community-Based Trial of Emollients for Atopic Dermatitis PreventionU34AR065739 · NIAMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI SIMPSON, ERIC L · 2014 to 2015
$678k
Medical Research Council G0601361Medical Research Council MR/K002449/1NIAID NIH HHS R01 AI126915NIAMS NIH HHS K08 AR065577NIAMS NIH HHS R01 AR070116NIAMS NIH HHS U34 AR065739
6 · The paper itself

Abstract

Atopic dermatitis (AD) affects up to 20% of children worldwide and is an increasing public health problem, particularly in developed countries. Although AD in infants and young children can resolve, there is a well-recognized increased risk of sequential progression from AD to other atopic diseases, including food allergy (FA), allergic rhinitis, allergic asthma, and allergic rhinoconjunctivitis, a process referred to as the atopic march. The mechanisms underlying the development of AD and subsequent progression to other atopic comorbidities, particularly FA, are incompletely understood and the subject of intense investigation. Other major research objectives are the development of effective strategies to prevent AD and FA, as well as therapeutic interventions to inhibit the atopic march. In 2017, the Division of Allergy, Immunology, and Transplantation of the National Institute of Allergy and Infectious Diseases sponsored a workshop to discuss current understanding and important advances in these research areas and to identify gaps in knowledge and future research directions. International and national experts in the field were joined by representatives from several National Institutes of Health institutes. Summaries of workshop presentations, key conclusions, and recommendations are presented herein.

Indexed as

Hypersensitivity, ImmediateSkin DiseasesAnimalsBiomarkersHumansMicrobiotaBiomarkersasthmaatopic dermatitisAtopic marchbiomarkersfood allergyinterventionsskin barrierskin microbiome

Identifiers

PMID30639346
PMCPMC6905466
OpenAlexW2908608981

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.