Evidence map›Paper›PMID 30639333›Full record

ArticleNeuroImage2019

Quantifying normal human brain metabolism using hyperpolarized [1-

James T Grist, Mary A McLean, Frank Riemer, Rolf F Schulte, Surrin S Deen, Fulvio Zaccagna, Ramona Woitek, Charlie J Daniels, Joshua D Kaggie, Tomasz Matys and 16 more

Open access · hybridAbstract read
In one paragraph

Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 1 pooled it
14.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 1 synthesis or guideline pooled it, 175 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Tracking Hyperpolarized [1-NMR in biomedicine · 2025
    Article
  10. Metabolic Imaging of Hyperpolarized [1-International journal of molecular sciences · 2025
    Article
  11. Article
  12. Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025
    Review
  13. Article
  14. Spatial distribution of hyperpolarized [1-Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Enhanced Solubility and Polarization ofACS applied materials & interfaces · 2024
    Article
  20. Current methods for hyperpolarized [1-Magnetic resonance in medicine · 2024
    Review

59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 5 institutions in 2 countries.

James T GristDepartment of Radiology, University of Cambridge, Cambridge, UK.
Mary A McLeanCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Frank RiemerDepartment of Radiology, University of Cambridge, Cambridge, UK.
Rolf F SchulteGeneral Electric Healthcare, Munich, Germany.
Surrin S DeenDepartment of Radiology, University of Cambridge, Cambridge, UK; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Fulvio ZaccagnaDepartment of Radiology, University of Cambridge, Cambridge, UK.
Ramona WoitekDepartment of Radiology, University of Cambridge, Cambridge, UK; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Charlie J DanielsDepartment of Radiology, University of Cambridge, Cambridge, UK.
Joshua D KaggieDepartment of Radiology, University of Cambridge, Cambridge, UK.
Tomasz MatysDepartment of Radiology, University of Cambridge, Cambridge, UK.
Ilse PattersonRadiology, Cambridge University Hospitals, Cambridge, UK.
Rhys SloughRadiology, Cambridge University Hospitals, Cambridge, UK.
Andrew B GillDepartment of Radiology, University of Cambridge, Cambridge, UK.
Anita ChhabraPharmacy, Cambridge University Hospitals, Cambridge, UK.
Rose EichenbergerUniversity of Cambridge, MRC Epidemiology Unit, Cambridge, UK.
Marie-Christine LaurentDepartment of Radiology, University of Cambridge, Cambridge, UK.
Arnaud CommentCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK; GE Healthcare, Chalfont St Giles, UK.
Jonathan H GillardDepartment of Radiology, University of Cambridge, Cambridge, UK.
Alasdair J ColesDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Damian J TylerDepartment of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, UK.
Ian WilkinsonDepartment of Medicine, University of Cambridge and Cambridge Clinical Trials Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Bristi BasuDepartment of Oncology, University of Cambridge, Cambridge, UK.
David J LomasDepartment of Radiology, University of Cambridge, Cambridge, UK.
Martin J GravesRadiology, Cambridge University Hospitals, Cambridge, UK.
Kevin M BrindleCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Ferdia A GallagherDepartment of Radiology, University of Cambridge, Cambridge, UK. Electronic address: fag1000@cam.ac.uk.
University of Cambridge · GBCambridge University Hospitals NHS Foundation Trust · GBCancer Research UK · GBGeneral Electric (Germany) · DEUniversity of Oxford · GB

Funding

Austrian Science Fund FWF J 4025British Heart Foundation FS/10/002/28078British Heart Foundation FS/14/17/30634British Heart Foundation FS/19/18/34252British Heart Foundation RG/11/9/28921Cancer Research UK 11562Cancer Research UK 16465Cancer Research UK 16628Cancer Research UK 28667Medical Research Council G0601490Wellcome Trust
6 · The paper itself

Abstract

Hyperpolarized

Indexed as

Carbon IsotopesPyruvic AcidAdultBrainFemaleHumansMagnetic Resonance ImagingMaleNeuroimagingCarbon IsotopesPyruvic AcidBrainCarbon-13HyperpolarizedMetabolismMRIPyruvate

Identifiers

PMID30639333
PMCPMC6435102
OpenAlexW2910792831

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.