Evidence map›Paper›PMID 30639325›Full record

ReviewSeminars in cell & developmental biology2019

Neural stem cell niche heterogeneity.

Julia P Andreotti, Walison N Silva, Alinne C Costa, Caroline C Picoli, Flávia C O Bitencourt, Leda M C Coimbra-Campos, Rodrigo R Resende, Luiz A V Magno, Marco A Romano-Silva, Akiva Mintz and 1 more

Abstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed.

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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Julia P AndreottiDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Walison N SilvaDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Alinne C CostaDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Caroline C PicoliDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Flávia C O BitencourtDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Leda M C Coimbra-CamposDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Rodrigo R ResendeDepartment of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Luiz A V MagnoDepartment of Mental Health, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Marco A Romano-SilvaDepartment of Mental Health, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Akiva MintzDepartment of Radiology, Columbia University Medical Center, New York, NY, USA.
Alexander BirbrairDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil; Department of Radiology, Columbia University Medical Center, New York, NY, USA. Electronic address: birbrair@icb.ufmg.br.

Funding

Therapeutically Exploiting a Newly Isolated Neural-Like Stem Cell Against GSBR01CA179072 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MINTZ, AKIVA · 2015 to 2020
$1.6M
Targeted Molecular Nano-Irradiation Against a Malignant Glioma BiomarkerR21NS067471 · NINDS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MINTZ, AKIVA · 2009 to 2010
$406k
NCI NIH HHS R01 CA179072NINDS NIH HHS R21 NS067471
6 · The paper itself

Abstract

In mammals, new neurons can be generated from neural stem cells in specific regions of the adult brain. Neural stem cells are characterized by their abilities to differentiate into all neural lineages and to self-renew. The specific microenvironments regulating neural stem cells, commonly referred to as neurogenic niches, comprise multiple cell populations whose precise contributions are under active current exploration. Understanding the cross-talk between neural stem cells and their niche components is essential for the development of therapies against neurological disorders in which neural stem cells function is altered. In this review, we describe and discuss recent studies that identified novel components in the neural stem cell niche. These discoveries bring new concepts to the field. Here, we evaluate these recent advances that change our understanding of the neural stem cell niche heterogeneity and its influence on neural stem cell function.

Indexed as

Stem Cell NicheAnimalsAutocrine CommunicationCerebrospinal FluidHumansNeural Stem CellsNeuronsSignal TransductionMaintenanceMicroenvironmentNeural stem cellNichePlasticity

Identifiers

PMID30639325
PMCPMC6710163

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.