Evidence map›Paper›PMID 30639224›Full record

ArticleBiochimica et biophysica acta. Molecular basis of disease2019

Deficiency of mouse mast cell protease 4 mitigates cardiac dysfunctions in mice after myocardium infarction.

Yunzhe Wang, Cong-Lin Liu, Wenqian Fang, Xian Zhang, Chongzhe Yang, Jie Li, Jing Liu, Galina K Sukhova, Michael F Gurish, Peter Libby and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. Molecular basis of disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Mast Cells in Cardiac Remodeling: Focus on the Right Ventricle.Journal of cardiovascular development and disease · 2024
    Review
  4. Review
  5. Article
  6. The Roles of Noncardiomyocytes in Cardiac Remodeling.International journal of biological sciences · 2020
    Review
  7. Review
  8. Wenxin Granules Influence the TGFCardiology research and practice · 2019
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Yunzhe WangDepartment of Cardiology, the First Affiliated Hospital of Zhengzhou University, Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou University, Zhengzhou 450000, China; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Cong-Lin LiuDepartment of Cardiology, the First Affiliated Hospital of Zhengzhou University, Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou University, Zhengzhou 450000, China; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Wenqian FangDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Xian ZhangDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Chongzhe YangDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Jie LiDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Jing LiuDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Galina K SukhovaDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Michael F GurishDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Peter LibbyDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Guo-Ping ShiDepartment of Cardiology, the First Affiliated Hospital of Zhengzhou University, Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou University, Zhengzhou 450000, China; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: gshi@rics.bwh.harvard.edu.
Jinying ZhangDepartment of Cardiology, the First Affiliated Hospital of Zhengzhou University, Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou University, Zhengzhou 450000, China. Electronic address: jyzhang@zzu.edu.cn.
Brigham and Women's Hospital · USFirst Affiliated Hospital of Zhengzhou University · CN

Funding

Role of mast cells in obesityR01HL060942 · NHLBI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI SHI, GUO-PING · 1999 to 2019
$5.6M
Molecular Determinants of Arterial Remodeling in AtherogenesisR01HL080472 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2005 to 2018
$5.0M
Role of a novel IL18 binding protein in atherosclerosisR01HL123568 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SHI, GUO-PING · 2015 to 2018
$1.7M
Role of mast cells in Alzheimer's DiseaseR56AG058670 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI SHI, GUO-PING · 2018 to 2018
$415k
NHLBI NIH HHS R01 HL060942NHLBI NIH HHS R01 HL080472NHLBI NIH HHS R01 HL123568NIA NIH HHS R56 AG058670
6 · The paper itself

Abstract

Mouse mast cell protease-4 (mMCP4) is a chymase that has been implicated in cardiovascular diseases, including myocardial infarction (MI). This study tested a direct role of mMCP4 in mouse post-MI cardiac dysfunction and myocardial remodeling. Immunoblot and immunofluorescent double staining demonstrated mMCP4 expression in cardiomyocytes from the infarct zone from mouse heart at 28 day post-MI. At this time point, mMCP4-deficient Mcpt4

Indexed as

Ventricular RemodelingAnimalsApoptosisCells, CulturedFibroblastsFibrosisMaleMice, Inbred C57BLMice, KnockoutMyocardial InfarctionMyocardiumMyocytes, CardiacSerine EndopeptidasesSmad2 ProteinSmad3 ProteinTransforming Growth Factor beta1mast cell protease 4Serine EndopeptidasesSmad2 ProteinSmad2 protein, mouseSmad3 ProteinSmad3 protein, mouseTgfb1 protein, mouseTransforming Growth Factor beta1ApoptosisCardiomyocyteFibroblastFibrosismMCP4Myocardial infarction

Identifiers

PMID30639224
PMCPMC6502670
OpenAlexW2911195168

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.