ArticleNeuroImage. Clinical2019
Thalamic diaschisis following perinatal stroke is associated with clinical disability.
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Neuroimaging and Neurological Outcomes in Perinatal Arterial Ischemic Stroke: A Systematic Review and Meta-Analysis.Pediatric neurology · 2024Pooled it
- Visuo-perceptual Abilities in Children With Perinatal Arterial Ischemic Stroke and Associated White Matter Microstructure.Journal of child neurology · 2026Article
- Deep grey nuclei automated assessment in acute-subacute phase of middle cerebral artery cortical stroke helps predict the 3-month outcome.Brain imaging and behavior · 2026Article
- Thalamic oscillatory dysrhythmia and disrupted functional connectivity in thalamocortical loops in perinatal stroke.Scientific reports · 2025Article
- Executive functioning, ADHD symptoms and resting state functional connectivity in children with perinatal stroke.Brain imaging and behavior · 2024Article
- Brain growth until adolescence after a neonatal focal injury: sex related differences beyond lesion effect.Frontiers in neuroscience · 2024Article
- Alterations in cortical morphometry of the contralesional hemisphere in children, adolescents, and young adults with perinatal stroke.Scientific reports · 2023Article
- Vascular tortuosity is related to reduced thalamic volume after middle cerebral artery occlusion.Heliyon · 2023Article
- The thalamus and basal ganglia are smaller in children with epilepsy after perinatal stroke.Frontiers in neurology · 2023Article
- BCI-activated electrical stimulation in children with perinatal stroke and hemiparesis: A pilot study.Frontiers in human neuroscience · 2023Article
- Thalamic Volume Loss Is Greater in Children Than in Adults Following Middle Cerebral Artery Territory Arterial Ischemic Stroke.Journal of child neurology · 2022Article
- Chronic cerebral hypoperfusion and blood-brain barrier disruption in uninjured brain areas of rhesus monkeys subjected to transient ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Structural connectivity of the sensorimotor network within the non-lesioned hemisphere of children with perinatal stroke.Scientific reports · 2022Article
- Ipsilesional volume loss of basal ganglia and thalamus is associated with poor hand function after ischemic perinatal stroke.BMC neurology · 2022Article
- Frontal interhemispheric structural connectivity, attention, and executive function in children with perinatal stroke.Brain and behavior · 2022Article
- Bihemispheric developmental alterations in basal ganglia volumes following unilateral perinatal stroke.NeuroImage. Clinical · 2022Article
- Cognitive outcome is related to functional thalamo-cortical connectivity after paediatric stroke.Brain communications · 2022Article
- Perinatal stroke: mapping and modulating developmental plasticity.Nature reviews. Neurology · 2021Review
- Head circumference trajectory in children with perinatal stroke.Journal of child neurology · 2021Article
- A connectome-based approach to assess motor outcome after neonatal arterial ischemic stroke.Annals of clinical and translational neurology · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPerinatal stroke causes most hemiparetic cerebral palsy and leads to lifelong disability. Understanding developmental neuroplasticity following early stroke is increasingly translated into novel therapies. Diaschisis refers to alterations brain structures remote from, but connected to, stroke lesions. Ipsilesional thalamic diaschisis has been described following adult stroke but has not been investigated in perinatal stroke. We hypothesized that thalamic diaschisis occurs in perinatal stroke and its degree would be inversely correlated with clinical motor function.
methodsPopulation-based, controlled cohort study. Participants were children (<19 years) with unilateral perinatal stroke (arterial ischemic stroke [AIS] or periventricular venous infarction [PVI]), anatomical magnetic resonance imaging (MRI) >6 months of age, symptomatic hemiparetic cerebral palsy, and no additional neurologic disorders. Typically developing controls had comparable age and gender proportions. T1-weighted anatomical scans were parcellated into 99 regions of interest followed by generation of regional volumes. The primary outcome was thalamic volume expressed as ipsilesional (ILTV), contralesional (CLTV) and thalamic ratio (CLTV/ILTV). Standardized clinical motor assessments were correlated with thalamic volume metrics.
resultsFifty-nine participants (12.9 years old ±4.0 years, 46% female) included 20 AIS, 11 PVI, and 28 controls. ILTV was reduced in both AIS and PVI compared to controls (p < .001, p = .029, respectively). Ipsilesional thalamic diaschisis was not associated with clinical motor function. However, CLTV was significantly larger in AIS compared to both controls and PVI (p = .005, p < .001, respectively). CLTV was inversely correlated with all four clinical motor assessments (all p < .003).
conclusionBilateral thalamic volume changes occur after perinatal stroke. Ipsilesional volume loss is not associated with clinical motor function. Contralesional volume is inversely correlated with clinical motor function, suggesting the thalamus is involved in the known developmental plasticity that occurs in the contralesional hemisphere after early unilateral injury.
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